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5VPK	CRYSTAL STRUCTURE OF MITE ALLERGEN DER F 1 Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Der f 1 variant, SULFATE ION Authors: Chruszcz, M, Chapman, M.D, Vailes, L.D, Pomes, A, Minor, W. Deposit date: 2017-05-05 Release date: 2017-05-24 Last modified: 2023-10-04 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal Structures Of Mite Allergens Der F 1 And Der P 1 Reveal Differences In Surface-Exposed Residues That May Influence Antibody Binding J.Mol.Biol., 386, 2009
4N4Z	Trypanosoma brucei procathepsin B structure solved by Serial Microcrystallography using synchrotron radiation Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Cysteine peptidase C (CPC), beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose Authors: Gati, C, Bourenkov, G, Klinge, M, Rehders, D, Stellato, F, Oberthuer, D, White, T.A, Yevanov, O, Sommer, B.P, Mogk, S, Duszenko, M, Betzel, C, Schneider, T.R, Chapman, H.N, Redecke, L. Deposit date: 2013-10-08 Release date: 2014-02-05 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.3 Å) Cite: Serial crystallography on in vivo grown microcrystals using synchrotron radiation. IUCrJ, 1, 2014
4N79	Structure of Cathepsin K-dermatan sulfate complex Descriptor: Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose Authors: Aguda, A.H, Nguyen, N.T, Bromme, D, Brayer, G.D. Deposit date: 2013-10-15 Release date: 2014-11-26 Last modified: 2020-07-29 Method: X-RAY DIFFRACTION (2.62 Å) Cite: Structural basis of collagen fiber degradation by cathepsin K. Proc.Natl.Acad.Sci.USA, 111, 2014
1THE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN Descriptor: Cathepsin B, amino{[(4S)-4-{[(benzyloxy)carbonyl]amino}-5-{[(2S)-1-(benzyloxy)-4-chloro-3-oxobutan-2-yl]amino}-5-oxopentyl]amino}met haniminium Authors: Huber, C.P, Jia, Z. Deposit date: 1995-09-15 Release date: 1996-03-10 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
4PI3	Crystal structure analysis of cruzain bound to vinyl sulfone analog of WRR-483 (WRR-666) Descriptor: Cruzipain, N-[(2S)-5-(carbamimidamidooxy)-1-oxo-1-{[(1E,3S)-5-phenyl-1-(phenylsulfonyl)pent-1-en-3-yl]amino}pentan-2-yl]-4-methylpiperazine-1-carboxamide Authors: Tochowicz, A, McKerrow, J.H. Deposit date: 2014-05-08 Release date: 2014-11-12 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (1.27 Å) Cite: Synthesis and Evaluation of Oxyguanidine Analogues of the Cysteine Protease Inhibitor WRR-483 against Cruzain. Acs Med.Chem.Lett., 7, 2016
3QSD	Structure of cathepsin B1 from Schistosoma mansoni in complex with CA074 inhibitor Descriptor: ACETATE ION, Cathepsin B-like peptidase (C01 family), DI(HYDROXYETHYL)ETHER, ... Authors: Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. Deposit date: 2011-02-21 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.3 Å) Cite: Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
1CSB	Crystal structure of cathepsin b inhibited with CA030 at 2.1 angstroms resolution: A basis for the design of specific epoxysuccinyl inhibitors Descriptor: CATHEPSIN B heavy chain, CATHEPSIN B light chain, N-[(3R)-4-ethoxy-3-hydroxy-4-oxobutanoyl]-L-isoleucyl-L-proline Authors: Turk, D, Bode, W. Deposit date: 1994-12-09 Release date: 1996-04-03 Last modified: 2012-12-12 Method: X-RAY DIFFRACTION (2 Å) Cite: Crystal structure of cathepsin B inhibited with CA030 at 2.0-A resolution: A basis for the design of specific epoxysuccinyl inhibitors. Biochemistry, 34, 1995
4P6E	Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor Descriptor: Cathepsin S, N-[(8R)-8-(benzoylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide, SULFATE ION Authors: Wang, Y, Jadhav, P.K, Deng, G.G. Deposit date: 2014-03-24 Release date: 2014-10-29 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. Acs Med.Chem.Lett., 5, 2014
3S3Q	Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor Descriptor: ACETATE ION, Cathepsin B-like peptidase (C01 family), N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide Authors: Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. Deposit date: 2011-05-18 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
1U9Q	Crystal structure of cruzain bound to an alpha-ketoester Descriptor: [1-(1-METHYL-4,5-DIOXO-PENT-2-ENYLCARBAMOYL)-2-PHENYL-ETHYL]-CARBAMIC ACID BENZYL ESTER, cruzipain Authors: Lange, M, Weston, S.G, Cheng, H, Culliane, M, Fiorey, M.M, Grisostomi, C, Hardy, L.W, Hartstough, D.S, Pallai, P.V, Tilton, R.F, Baldino, C.M, Brinen, L.S, Engel, J.C, Choe, Y, Price, M.S, Craik, C.S. Deposit date: 2004-08-10 Release date: 2005-03-29 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Development of alpha-keto-based inhibitors of cruzain, a cysteine protease implicated in Chagas disease Bioorg.Med.Chem., 13, 2005
1CQD	THE 2.1 ANGSTROM STRUCTURE OF A CYSTEINE PROTEASE WITH PROLINE SPECIFICITY FROM GINGER RHIZOME, ZINGIBER OFFICINALE Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PROTEIN (PROTEASE II), ... Authors: Choi, K.H, Laursen, R.A, Allen, K.N. Deposit date: 1999-06-15 Release date: 1999-09-28 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (2.1 Å) Cite: The 2.1 A structure of a cysteine protease with proline specificity from ginger rhizome, Zingiber officinale. Biochemistry, 38, 1999
1U9W	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491 Descriptor: 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE, Cathepsin K Authors: Cowan-Jacob, S.W. Deposit date: 2004-08-11 Release date: 2005-08-11 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1U9V	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854 Descriptor: 6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE, Cathepsin K Authors: Cowan-Jacob, S.W. Deposit date: 2004-08-11 Release date: 2005-08-11 Last modified: 2023-10-25 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1CVZ	CRYSTAL STRUCTURE ANALYSIS OF PAPAIN WITH CLIK148(CATHEPSIN L SPECIFIC INHIBITOR) Descriptor: N1-(1-DIMETHYLCARBAMOYL-2-PHENYL-ETHYL)-2-OXO-N4-(2-PYRIDIN-2-YL-ETHYL)-SUCCINAMIDE, PAPAIN Authors: Tsuge, H. Deposit date: 1999-08-24 Release date: 2000-08-30 Last modified: 2022-12-21 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Inhibition mechanism of cathepsin L-specific inhibitors based on the crystal structure of papain-CLIK148 complex. Biochem.Biophys.Res.Commun., 266, 1999
1TU6	Cathepsin K complexed with a ketoamide inhibitor Descriptor: Cathepsin K, SULFATE ION, [1-(4-FLUOROBENZYL)CYCLOBUTYL]METHYL (1S)-1-[OXO(1H-PYRAZOL-5-YLAMINO)ACETYL]PENTYLCARBAMATE Authors: Barrett, D.G, Catalano, J.G, Deaton, D.N, Hassell, A.M, Long, S.T, Miller, A.B, Miller, L.R, Shewchuk, L.M, Wells-Knecht, K.J, Wright, L.L. Deposit date: 2004-06-24 Release date: 2004-09-21 Last modified: 2023-08-23 Method: X-RAY DIFFRACTION (1.75 Å) Cite: Potent and selective P2-P3 ketoamide inhibitors of cathepsin K with improved pharmacokinetic properties via favorable P1', P1, and/or P3 substitutions BIOORG.MED.CHEM.LETT., 14, 2004
1CPJ	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN Descriptor: CATHEPSIN B Authors: Huber, C.P, Jia, Z. Deposit date: 1995-07-17 Release date: 1995-12-07 Last modified: 2021-11-03 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
1U9X	Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688 Descriptor: 9-CYCLOPENTYL-6-{2-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPOXY]-PHENYLAMINO}-9H-PURINE-2-CARBONITRILE, Cathepsin K Authors: Cowan-Jacob, S.W. Deposit date: 2004-08-11 Release date: 2005-08-11 Last modified: 2017-10-11 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47, 2004
1CTE	CRYSTAL STRUCTURES OF RECOMBINANT RAT CATHEPSIN B AND A CATHEPSIN B-INHIBITOR COMPLEX: IMPLICATIONS FOR STRUCTURE-BASED INHIBITOR DESIGN Descriptor: 2-PYRIDINETHIOL, CATHEPSIN B Authors: Huber, C.P, Jia, Z. Deposit date: 1995-05-03 Release date: 1995-07-31 Last modified: 2024-06-05 Method: X-RAY DIFFRACTION (2.1 Å) Cite: Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design. J.Biol.Chem., 270, 1995
4P6G	Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor. Descriptor: (3R,4S)-4-[(4-fluorobenzoyl)amino]-6-[4-(oxetan-3-yl)piperazin-1-yl]-3,4-dihydro-2H-chromen-3-yl methylcarbamate, Cathepsin S Authors: Wang, Y, Jadhav, P.K. Deposit date: 2014-03-24 Release date: 2014-10-29 Last modified: 2023-12-27 Method: X-RAY DIFFRACTION (1.58 Å) Cite: Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm. Acs Med.Chem.Lett., 5, 2014
1DEU	CRYSTAL STRUCTURE OF HUMAN PROCATHEPSIN X: A CYSTEINE PROTEASE WITH THE PROREGION COVALENTLY LINKED TO THE ACTIVE SITE CYSTEINE Descriptor: PROCATHEPSIN X Authors: Sivaraman, J, Nagler, D.K, Zhang, R, Menard, R, Cygler, M. Deposit date: 1999-11-15 Release date: 2000-02-18 Last modified: 2023-08-09 Method: X-RAY DIFFRACTION (1.7 Å) Cite: Crystal structure of human procathepsin X: a cysteine protease with the proregion covalently linked to the active site cysteine. J.Mol.Biol., 295, 2000
4PAD	Binding of chloromethyl ketone substrate analogues to crystalline papain Descriptor: N-[(1S)-5-amino-1-(chloroacetyl)pentyl]-4-methylbenzenesulfonamide, PAPAIN Authors: Drenth, J. Deposit date: 1976-11-01 Release date: 1977-04-12 Last modified: 2023-09-27 Method: X-RAY DIFFRACTION (2.8 Å) Cite: Binding of chloromethyl ketone substrate analogues to crystalline papain. Biochemistry, 15, 1976
3S3R	Structure of cathepsin B1 from Schistosoma mansoni in complex with K11777 inhibitor Descriptor: Cathepsin B-like peptidase (C01 family), Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide Authors: Rezacova, P, Jilkova, A, Brynda, J, Horn, M, Mares, M. Deposit date: 2011-05-18 Release date: 2011-08-10 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (2.64 Å) Cite: Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286, 2011
1VSN	Crystal structure of a potent small molecule inhibitor bound to cathepsin K Descriptor: Cathepsin K, N-(2-AMINOETHYL)-N~2~-{(1S)-1-[4'-(AMINOSULFONYL)BIPHENYL-4-YL]-2,2,2-TRIFLUOROETHYL}-L-LEUCINAMIDE Authors: McGrath, M. Deposit date: 2007-03-19 Release date: 2007-04-24 Last modified: 2024-10-16 Method: X-RAY DIFFRACTION (2 Å) Cite: Identification of a potent and selective non-basic cathepsin K inhibitor. Bioorg.Med.Chem.Lett., 16, 2006
4QH6	Crystal structure of cruzain with nitrile inhibitor N-(2-AMINOETHYL)-NALPHA-BENZOYL-L-PHENYLALANINAMIDE Descriptor: Cruzipain, N-(2-aminoethyl)-Nalpha-benzoyl-L-phenylalaninamide Authors: Fernandes, W.B, Montanari, C.A, McKerrow, J.H. Deposit date: 2014-05-27 Release date: 2015-08-05 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (3.13 Å) Cite: Molecular Design, Synthesis and Trypanocidal Activity of Dipeptidyl Nitriles as Cruzain Inhibitors. Plos Negl Trop Dis, 9, 2015
3U8E	Crystal Structure of Cysteine Protease from Bulbs of Crocus sativus at 1.3 A Resolution Descriptor: GLYCEROL, Papain-like Cysteine Protease, SODIUM ION, ... Authors: Iqbal, S, Akrem, A, Buck, F, Perbandt, M, Banumathi, S, Betzel, C. Deposit date: 2011-10-17 Release date: 2011-10-26 Last modified: 2023-09-13 Method: X-RAY DIFFRACTION (1.31 Å) Cite: Crystal Structure of A Papain-like Cysteine Protease from Bulbs of Crocus sativum at 1.3 A resolution To be Published

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