3S3Q

Structure of cathepsin B1 from Schistosoma mansoni in complex with K11017 inhibitor

Summary for 3S3Q

Entry DOI	10.2210/pdb3s3q/pdb
Related	3QSD 3S3R
Descriptor	Cathepsin B-like peptidase (C01 family), N~2~-(morpholin-4-ylcarbonyl)-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-leucinamide, ACETATE ION, ... (4 entities in total)
Functional Keywords	peptidase, digestive tract, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Schistosoma mansoni (Blood fluke)
Total number of polymer chains	1
Total formula weight	29155.03
Authors	Rezacova, P.,Jilkova, A.,Brynda, J.,Horn, M.,Mares, M. (deposition date: 2011-05-18, release date: 2011-08-10, Last modification date: 2023-09-13)
Primary citation	Jilkova, A.,Rezacova, P.,Lepsik, M.,Horn, M.,Vachova, J.,Fanfrlik, J.,Brynda, J.,McKerrow, J.H.,Caffrey, C.R.,Mares, M. Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286:35770-35781, 2011 Cited by PubMed: 21832058 DOI: 10.1074/jbc.M111.271304 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.8 Å)

Structure validation