3S3R
Structure of cathepsin B1 from Schistosoma mansoni in complex with K11777 inhibitor
Summary for 3S3R
| Entry DOI | 10.2210/pdb3s3r/pdb |
| Related | 3QSD 3S3Q |
| Related PRD ID | PRD_000325 |
| Descriptor | Cathepsin B-like peptidase (C01 family), Nalpha-[(4-methylpiperazin-1-yl)carbonyl]-N-[(3S)-1-phenyl-5-(phenylsulfonyl)pentan-3-yl]-L-phenylalaninamide (3 entities in total) |
| Functional Keywords | peptidase, digestive tract, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Schistosoma mansoni (Blood fluke) |
| Total number of polymer chains | 3 |
| Total formula weight | 87252.02 |
| Authors | Rezacova, P.,Jilkova, A.,Brynda, J.,Horn, M.,Mares, M. (deposition date: 2011-05-18, release date: 2011-08-10, Last modification date: 2023-09-13) |
| Primary citation | Jilkova, A.,Rezacova, P.,Lepsik, M.,Horn, M.,Vachova, J.,Fanfrlik, J.,Brynda, J.,McKerrow, J.H.,Caffrey, C.R.,Mares, M. Structural Basis for Inhibition of Cathepsin B Drug Target from the Human Blood Fluke, Schistosoma mansoni. J.Biol.Chem., 286:35770-35781, 2011 Cited by PubMed: 21832058DOI: 10.1074/jbc.M111.271304 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.64 Å) |
Structure validation
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