1U9V
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABE854
Summary for 1U9V
| Entry DOI | 10.2210/pdb1u9v/pdb |
| Related | 1ATK 1MEM 1U9W 1U9X |
| Descriptor | Cathepsin K, 6-(CYCLOHEXYLAMINO)-9-[2-(4-METHYLPIPERAZIN-1-YL)-ETHYL]-9H-PURINE-2-CARBONITRILE (3 entities in total) |
| Functional Keywords | hydrolase, sulfhydryl proteinase |
| Biological source | Homo sapiens (human) |
| Cellular location | Lysosome: P43235 |
| Total number of polymer chains | 1 |
| Total formula weight | 24106.21 |
| Authors | Cowan-Jacob, S.W. (deposition date: 2004-08-11, release date: 2005-08-11, Last modification date: 2024-10-23) |
| Primary citation | Altmann, E.,Cowan-Jacob, S.W.,Missbach, M. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47:5833-5836, 2004 Cited by PubMed Abstract: Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors. PubMed: 15537340DOI: 10.1021/jm0493111 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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