1U9W
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABI491
Summary for 1U9W
Entry DOI | 10.2210/pdb1u9w/pdb |
Related | 1ATK 1MEM 1U9V 1U9X |
Descriptor | Cathepsin K, 9-CYCLOPENTYL-6-[2-(3-IMIDAZOL-1-YL-PROPOXY)-PHENYLAMINO]-9H-PURINE-2-CARBONITRILE (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24166.22 |
Authors | Cowan-Jacob, S.W. (deposition date: 2004-08-11, release date: 2005-08-11, Last modification date: 2017-10-11) |
Primary citation | Altmann, E.,Cowan-Jacob, S.W.,Missbach, M. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47:5833-5836, 2004 Cited by PubMed: 15537340DOI: 10.1021/jm0493111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.3 Å) |
Structure validation
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