1U9X
Crystal Structure of the Cysteine Protease Human Cathepsin K in Complex with the Covalent Inhibitor NVP-ABJ688
Summary for 1U9X
Entry DOI | 10.2210/pdb1u9x/pdb |
Related | 1ATK 1MEM 1U9V 1U9W |
Descriptor | Cathepsin K, 9-CYCLOPENTYL-6-{2-[3-(4-METHYL-PIPERAZIN-1-YL)-PROPOXY]-PHENYLAMINO}-9H-PURINE-2-CARBONITRILE (3 entities in total) |
Functional Keywords | hydrolase, sulfhydryl proteinase |
Biological source | Homo sapiens (human) |
Cellular location | Lysosome: P43235 |
Total number of polymer chains | 1 |
Total formula weight | 24198.30 |
Authors | Cowan-Jacob, S.W. (deposition date: 2004-08-11, release date: 2005-08-11, Last modification date: 2017-10-11) |
Primary citation | Altmann, E.,Cowan-Jacob, S.W.,Missbach, M. Novel purine nitrile derived inhibitors of the cysteine protease cathepsin K J.Med.Chem., 47:5833-5836, 2004 Cited by PubMed Abstract: Starting from the high-throughput screening hit 1a, novel cathepsin K inhibitors have been developed based on a purine scaffold. High-resolution X-ray structures of several derivatives have revealed the binding mode of these unique cysteine protease inhibitors. PubMed: 15537340DOI: 10.1021/jm0493111 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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