4P6E

Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor

Summary for 4P6E

• Entry DOI: 10.2210/pdb4p6e/pdb
• Descriptor: Cathepsin S, SULFATE ION, N-[(8R)-8-(benzoylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide, ... (4 entities in total)
• Functional Keywords: cysteine protease, cathepsin s, inhibitor, non-covalent, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (Human)
• Cellular location: Lysosome: P25774
• Total number of polymer chains: 2
• Total formula weight: 52176.42

Authors

Wang, Y.,Jadhav, P.K.,Deng, G.G. (deposition date: 2014-03-24, release date: 2014-10-29, Last modification date: 2023-12-27)

• Primary citation: Jadhav, P.K.,Schiffler, M.A.,Gavardinas, K.,Kim, E.J.,Matthews, D.P.,Staszak, M.A.,Coffey, D.S.,Shaw, B.W.,Cassidy, K.C.,Brier, R.A.,Zhang, Y.,Christie, R.M.,Matter, W.F.,Qing, K.,Durbin, J.D.,Wang, Y.,Deng, G.G.; Discovery of Cathepsin S Inhibitor LY3000328 for the Treatment of Abdominal Aortic Aneurysm.; Acs Med.Chem.Lett., 5:1138-1142, 2014; PubMed: 25313327; DOI: 10.1021/ml500283g

Experimental method

X-RAY DIFFRACTION (1.8 Å)