4P6E
Crystal Structure of Human Cathepsin S Bound to a Non-covalent Inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Cathepsin S | polymer | 230 | 25647.7 | 2 | UniProt (P25774) Pfam (PF00112) | Homo sapiens (Human) | |
| 2 | C (A) | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 3 | D, E (A, B) | N-[(8R)-8-(benzoylamino)-5,6,7,8-tetrahydronaphthalen-2-yl]-4-methylpiperazine-1-carboxamide | non-polymer | 392.5 | 2 | Chemie (2FC) | |||
| 4 | F, G (A, B) | water | water | 18.0 | 417 | Chemie (HOH) |
Sequence modifications
A, B: -5 - 217 (UniProt: P25774)
| PDB | External Database | Details |
|---|---|---|
| Glu 218 | - | expression tag |
| His 219 | - | expression tag |
| His 220 | - | expression tag |
| His 221 | - | expression tag |
| His 222 | - | expression tag |
| His 223 | - | expression tag |
| His 224 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51295.4 | |
| Non-Polymers* | Number of molecules | 3 |
| Total formula weight | 881.1 | |
| All* | Total formula weight | 52176.4 |
