4N79

Structure of Cathepsin K-dermatan sulfate complex

Summary for 4N79

• Entry DOI: 10.2210/pdb4n79/pdb
• Related: 4N8W
• Descriptor: Cathepsin K, alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose-(1-4)-alpha-L-idopyranuronic acid-(1-3)-2-acetamido-2-deoxy-4-O-sulfo-beta-D-galactopyranose (3 entities in total)
• Functional Keywords: collaginase, glycosaminoglycan, hydrolase
• Biological source: Homo sapiens (human)
• Cellular location: Lysosome: P43235
• Total number of polymer chains: 1
• Total formula weight: 24919.63

Authors

Aguda, A.H.,Nguyen, N.T.,Bromme, D.,Brayer, G.D. (deposition date: 2013-10-15, release date: 2014-11-26, Last modification date: 2020-07-29)

• Primary citation: Aguda, A.H.,Panwar, P.,Du, X.,Nguyen, N.T.,Brayer, G.D.,Bromme, D.; Structural basis of collagen fiber degradation by cathepsin K.; Proc.Natl.Acad.Sci.USA, 111:17474-17479, 2014; PubMed: 25422423; DOI: 10.1073/pnas.1414126111

Experimental method

X-RAY DIFFRACTION (2.62 Å)