7XBX
| Cryo-EM structure of the human chemokine receptor CX3CR1 in complex with CX3CL1 and Gi1 | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Lu, M, Zhao, W, Han, S, Zhu, Y, Wu, B, Zhao, Q. | 登録日 | 2022-03-22 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Activation of the human chemokine receptor CX3CR1 regulated by cholesterol. Sci Adv, 8, 2022
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7XBD
| Cryo-EM structure of human galanin receptor 2 | 分子名称: | Galanin, Galanin receptor type 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Ishimoto, N, Kita, S, Park, S.Y. | 登録日 | 2022-03-21 | 公開日 | 2022-07-13 | 最終更新日 | 2022-08-10 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Structure of the human galanin receptor 2 bound to galanin and Gq reveals the basis of ligand specificity and how binding affects the G-protein interface. Plos Biol., 20, 2022
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7XAV
| Structure of somatostatin receptor 2 bound with lanreotide. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.87 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7XAU
| Structure of somatostatin receptor 2 bound with octreotide. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.97 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7XAT
| Structure of somatostatin receptor 2 bound with SST14. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Bo, Q, Yang, F, Li, Y.G, Meng, X.Y, Zhang, H.H, Zhou, Y.X, Ling, S.L, Sun, D.M, Lv, P, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-03-19 | 公開日 | 2022-08-31 | 実験手法 | ELECTRON MICROSCOPY (2.85 Å) | 主引用文献 | Structural insights into the activation of somatostatin receptor 2 by cyclic SST analogues. Cell Discov, 8, 2022
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7XA3
| Cryo-EM structure of the CCL2 bound CCR2-Gi complex | 分子名称: | C-C motif chemokine 2, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-17 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7X9Y
| Cryo-EM structure of the apo CCR3-Gi complex | 分子名称: | C-C chemokine receptor type 3, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Shao, Z, Tan, Y, Shen, Q, Yao, B, Hou, L, Qin, J, Xu, P, Mao, C, Chen, L, Zhang, H, Shen, D, Zhang, C, Li, W, Du, X, Li, F, Chen, Z, Jiang, Y, Xu, H.E, Ying, S, Ma, H, Zhang, Y, Shen, H. | 登録日 | 2022-03-16 | 公開日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Molecular insights into ligand recognition and activation of chemokine receptors CCR2 and CCR3. Cell Discov, 8, 2022
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7X9B
| Cryo-EM structure of neuropeptide Y Y2 receptor in complex with NPY and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7X9C
| Cryo-EM structure of neuropeptide Y Y4 receptor in complex with PP and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7X9A
| Cryo-EM structure of neuropeptide Y Y1 receptor in complex with NPY and Gi | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Tang, T, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-03-15 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Receptor-specific recognition of NPY peptides revealed by structures of NPY receptors. Sci Adv, 8, 2022
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7X5H
| Serotonin 5A (5-HT5A) receptor-Gi protein complex | 分子名称: | 3-(2-azanylethyl)-1H-indole-5-carboxamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Tan, Y, Xu, P, Huang, S, Xu, H.E, Jiang, Y. | 登録日 | 2022-03-04 | 公開日 | 2022-09-14 | 最終更新日 | 2022-09-21 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural insights into the ligand binding and G i coupling of serotonin receptor 5-HT 5A . Cell Discov, 8, 2022
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7X2F
| Cryo-EM structure of the dopamine and LY3154207-bound D1 dopamine receptor and mini-Gs complex | 分子名称: | 2-[2,6-bis(chloranyl)phenyl]-1-[(1S,3R)-3-(hydroxymethyl)-1-methyl-5-(3-methyl-3-oxidanyl-butyl)-3,4-dihydro-1H-isoquinolin-2-yl]ethanone, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Teng, X, Zheng, S. | 登録日 | 2022-02-25 | 公開日 | 2022-06-15 | 最終更新日 | 2022-06-22 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun, 13, 2022
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7X2D
| Cryo-EM structure of the tavapadon-bound D1 dopamine receptor and mini-Gs complex | 分子名称: | 1,5-dimethyl-6-[2-methyl-4-[3-(trifluoromethyl)pyridin-2-yl]oxy-phenyl]pyrimidine-2,4-dione, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Teng, X, Zheng, S. | 登録日 | 2022-02-25 | 公開日 | 2022-06-15 | 最終更新日 | 2022-10-12 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun, 13, 2022
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7X2C
| Cryo-EM structure of the fenoldopam-bound D1 dopamine receptor and mini-Gs complex | 分子名称: | (1R)-6-chloranyl-1-(4-hydroxyphenyl)-2,3,4,5-tetrahydro-1H-3-benzazepine-7,8-diol, CHOLESTEROL, D(1A) dopamine receptor, ... | 著者 | Teng, X, Zheng, S. | 登録日 | 2022-02-25 | 公開日 | 2022-06-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Ligand recognition and biased agonism of the D1 dopamine receptor. Nat Commun, 13, 2022
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7X1T
| Structure of Thyrotropin-Releasing Hormone Receptor bound with Taltirelin. | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ScFv16, ... | 著者 | Yang, F, Zhang, H.H, Meng, X.Y, Li, Y.G, Zhou, Y.X, Ling, S.L, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.26 Å) | 主引用文献 | Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Res., 32, 2022
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7X1U
| Structure of Thyrotropin-Releasing Hormone Receptor bound with an Endogenous Peptide Agonist TRH. | 分子名称: | Endogenous Peptide Agonist TRH, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Yang, F, Zhang, H.H, Meng, X.Y, Li, Y.G, Zhou, Y.X, Ling, S.L, Liu, L, Shi, P, Tian, C.L. | 登録日 | 2022-02-24 | 公開日 | 2022-08-31 | 最終更新日 | 2022-09-14 | 実験手法 | ELECTRON MICROSCOPY (3.19 Å) | 主引用文献 | Structural insights into thyrotropin-releasing hormone receptor activation by an endogenous peptide agonist or its orally administered analogue. Cell Res., 32, 2022
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7U2L
| C5guano-uOR-Gi-scFv16 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Qu, Q, Skiniotis, G, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-05-04 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7U2K
| C6-guano bound Mu Opioid Receptor-Gi Protein Complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Wang, H, Kobilka, B. | 登録日 | 2022-02-24 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-08 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structure-based design of bitopic ligands for the μ-opioid receptor. Nature, 613, 2023
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7WZ4
| Structure of an orphan GPCR-G protein signaling complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Xu, J, Chen, G, Liu, Z, Du, Y. | 登録日 | 2022-02-17 | 公開日 | 2022-10-26 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Activation and allosteric regulation of the orphan GPR88-Gi1 signaling complex. Nat Commun, 13, 2022
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7YXA
| XFEL crystal structure of the human sphingosine 1 phosphate receptor 5 in complex with ONO-5430608 | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-[6-(2-naphthalen-1-ylethoxy)-2,3,4,5-tetrahydro-1H-3-benzazepin-3-ium-3-yl]butanoic acid, ... | 著者 | Lyapina, E, Marin, E, Gusach, A, Orekhov, P, Gerasimov, A, Luginina, A, Vakhrameev, D, Ergasheva, M, Kovaleva, M, Khusainov, G, Khorn, P, Shevtsov, M, Kovalev, K, Okhrimenko, I, Bukhdruker, S, Popov, P, Hu, H, Weierstall, U, Liu, W, Cho, Y, Gushchin, I, Rogachev, A, Bourenkov, G, Park, S, Park, G, Huyn, H.J, Park, J, Gordeliy, V, Borshchevskiy, V, Mishin, A, Cherezov, V. | 登録日 | 2022-02-15 | 公開日 | 2022-08-10 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural basis for receptor selectivity and inverse agonism in S1P 5 receptors. Nat Commun, 13, 2022
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7WVW
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMYFINILTL and Gi2 | 分子名称: | FME-TYR-PHE-ILE-ASN-ILE-LEU-THE-LEU, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVY
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2 | 分子名称: | Amyloid-beta A4 protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVX
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fhumanin and Gi2 | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVU
| Cryo-EM structure of the human formyl peptide receptor 1 in complex with fMLF and Gi1 | 分子名称: | FME-LEU-PHE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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7WVV
| Cryo-EM structure of the human formyl peptide receptor 2 in complex with fMLFII and Gi2 | 分子名称: | FME-LEU-PHE-ILE-ILE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Zhu, Y, Lin, X, Zong, X, Han, S, Zhao, Q, Wu, B. | 登録日 | 2022-02-11 | 公開日 | 2022-04-13 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin. Nat Commun, 13, 2022
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