7WVY

Cryo-EM structure of the human formyl peptide receptor 2 in complex with Abeta42 and Gi2

Summary for 7WVY

• Entry DOI: 10.2210/pdb7wvy/pdb
• EMDB information: 32862
• Descriptor: Amyloid-beta A4 protein, Soluble cytochrome b562,N-formyl peptide receptor 2, Guanine nucleotide-binding protein G(i) subunit alpha-2, ... (5 entities in total)
• Functional Keywords: g protein-coupled receptor, formyl peptide receptor, fpr2, abeta42, signaling protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 148338.79

Authors

Zhu, Y.,Lin, X.,Zong, X.,Han, S.,Zhao, Q.,Wu, B. (deposition date: 2022-02-11, release date: 2022-04-13)

• Primary citation: Zhu, Y.,Lin, X.,Zong, X.,Han, S.,Wang, M.,Su, Y.,Ma, L.,Chu, X.,Yi, C.,Zhao, Q.,Wu, B.; Structural basis of FPR2 in recognition of A beta 42 and neuroprotection by humanin.; Nat Commun, 13:1775-1775, 2022; PubMed: 35365641; DOI: 10.1038/s41467-022-29361-x

Experimental method

ELECTRON MICROSCOPY (3 Å)