2WRX
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![BU of 2wrx by Molmil](/molmil-images/mine/2wrx) | Semi-synthetic analogue of human insulin NMeAlaB26-insulin at pH 3.0 | Descriptor: | INSULIN A CHAIN, INSULIN B CHAIN, SODIUM ION | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-02 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2WS6
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![BU of 2ws6 by Molmil](/molmil-images/mine/2ws6) | Semi-synthetic analogue of human insulin NMeTyrB26-insulin in hexamer form | Descriptor: | CHLORIDE ION, GLYCEROL, INSULIN A CHAIN, ... | Authors: | Brzozowski, A.M, Jiracek, J, Zakova, L, Antolikova, E, Watson, C.J, Turkenburg, J.P, Dodson, G.G. | Deposit date: | 2009-09-03 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Implications for the Active Form of Human Insulin Based on the Structural Convergence of Highly Active Hormone Analogues. Proc.Natl.Acad.Sci.USA, 107, 2010
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2KQP
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![BU of 2kqp by Molmil](/molmil-images/mine/2kqp) | |
3I40
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![BU of 3i40 by Molmil](/molmil-images/mine/3i40) | Human insulin | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Chuprov-Netochin, R.N, Kuranova, I.P. | Deposit date: | 2009-07-01 | Release date: | 2010-01-05 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid. Acta Crystallogr.,Sect.F, 66, 2010
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3I3Z
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![BU of 3i3z by Molmil](/molmil-images/mine/3i3z) | Human insulin | Descriptor: | Insulin A chain, Insulin B chain | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Cuprov-Netochin, R.N, Samigina, V.R, Kuranova, I.P. | Deposit date: | 2009-07-01 | Release date: | 2010-01-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid. Acta Crystallogr.,Sect.F, 66, 2010
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2W44
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![BU of 2w44 by Molmil](/molmil-images/mine/2w44) | Structure DeltaA1-A4 insulin | Descriptor: | CHLORIDE ION, INSULIN, RESORCINOL, ... | Authors: | Thorsoee, K.S, Schlein, M, Brandt, J, Schluckebier, G, Naver, H. | Deposit date: | 2008-11-21 | Release date: | 2009-12-22 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Kinetic Evidence for the Sequential Association of Insulin Binding Sites 1 and 2 to the Insulin Receptor and the Influence of Receptor Isoform. Biochemistry, 49, 2010
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3FHP
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![BU of 3fhp by Molmil](/molmil-images/mine/3fhp) | A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution | Descriptor: | Insulin, ZINC ION | Authors: | Iwai, W, Kurihara, K, Yamada, T, Kobayashi, Y, Ohnishi, Y, Tanaka, I, Takahashi, H, Niimura, N. | Deposit date: | 2008-12-09 | Release date: | 2009-10-20 | Last modified: | 2023-11-01 | Method: | NEUTRON DIFFRACTION (2 Å) | Cite: | A neutron crystallographic analysis of T6 porcine insulin at 2.1 A resolution Acta Crystallogr.,Sect.D, 65, 2009
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3E4Z
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![BU of 3e4z by Molmil](/molmil-images/mine/3e4z) | Crystal structure of human insulin degrading enzyme in complex with insulin-like growth factor II | Descriptor: | Insulin-degrading enzyme, Insulin-like growth factor II, ZINC ION | Authors: | Guo, Q, Manolopoulou, M, Tang, W.-J. | Deposit date: | 2008-08-12 | Release date: | 2009-08-18 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.28 Å) | Cite: | Molecular Basis for the Recognition and Cleavages of IGF-II, TGF-alpha, and Amylin by Human Insulin-Degrading Enzyme. J.Mol.Biol., 395, 2010
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3FQ9
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![BU of 3fq9 by Molmil](/molmil-images/mine/3fq9) | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | Descriptor: | Insulin, ZINC ION | Authors: | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | Deposit date: | 2009-01-07 | Release date: | 2009-08-04 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications. J.Biol.Chem., 284, 2009
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3EXX
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![BU of 3exx by Molmil](/molmil-images/mine/3exx) | |
3GKY
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![BU of 3gky by Molmil](/molmil-images/mine/3gky) | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | Deposit date: | 2009-03-11 | Release date: | 2009-03-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY. J.Biol.Chem., 284, 2009
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2WC0
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![BU of 2wc0 by Molmil](/molmil-images/mine/2wc0) | crystal structure of human insulin degrading enzyme in complex with iodinated insulin | Descriptor: | 1,4-DIETHYLENE DIOXIDE, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Manolopoulou, M, Guo, Q, Malito, E, Schilling, A.B, Tang, W.J. | Deposit date: | 2009-03-06 | Release date: | 2009-03-24 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Molecular Basis of Catalytic Chamber-Assisted Unfolding and Cleavage of Human Insulin by Human Insulin Degrading Enzyme. J.Biol.Chem., 284, 2009
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3E7Z
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![BU of 3e7z by Molmil](/molmil-images/mine/3e7z) | Structure of human insulin | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Timofeev, V.I, Lyashenko, A.V, Kislitsyn, Y.A, Baidus, A.N, Kuranova, I.P. | Deposit date: | 2008-08-19 | Release date: | 2009-02-24 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Structure of human insulin To be published
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3E7Y
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![BU of 3e7y by Molmil](/molmil-images/mine/3e7y) | Structure of human insulin | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | Authors: | Timofeev, V.I, Baidus, A.N, Kislitsyn, Y.A, Kuranova, I.P. | Deposit date: | 2008-08-19 | Release date: | 2009-02-24 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Structure of human insulin to be published
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2K91
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![BU of 2k91 by Molmil](/molmil-images/mine/2k91) | Enhancing the activity of insulin by stereospecific unfolding | Descriptor: | Insulin | Authors: | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2008-09-29 | Release date: | 2008-11-18 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
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2K9R
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![BU of 2k9r by Molmil](/molmil-images/mine/2k9r) | Enhancing the activity of insulin by stereospecific unfolding | Descriptor: | Insulin | Authors: | Hua, Q.X, Xu, B, Huang, K, Hu, S.Q, Nakarawa, S, Jia, W.H, Philips, N.F.P, Wittaker, L, Wittaker, J, Katsoyannis, P.G, Weiss, M.A. | Deposit date: | 2008-10-23 | Release date: | 2008-11-11 | Last modified: | 2021-10-20 | Method: | SOLUTION NMR | Cite: | Enhancing the Activity of a Protein by Stereospecific Unfolding: CONFORMATIONAL LIFE CYCLE OF INSULIN AND ITS EVOLUTIONARY ORIGINS. J.Biol.Chem., 284, 2009
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2RN5
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![BU of 2rn5 by Molmil](/molmil-images/mine/2rn5) | Humal Insulin Mutant B31Lys-B32Arg | Descriptor: | Insulin | Authors: | Bocian, W, Kozerski, L. | Deposit date: | 2007-12-06 | Release date: | 2008-10-28 | Last modified: | 2022-03-16 | Method: | SOLUTION NMR | Cite: | NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer Biopolymers, 89, 2008
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2ZPP
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![BU of 2zpp by Molmil](/molmil-images/mine/2zpp) | |
2VK0
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![BU of 2vk0 by Molmil](/molmil-images/mine/2vk0) | Crystal structure form ultalente insulin microcrystals | Descriptor: | 4-HYDROXY-BENZOIC ACID METHYL ESTER, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Wagner, A, Diez, J, Schulze-Briese, C, Schluckebier, G. | Deposit date: | 2007-12-14 | Release date: | 2008-09-16 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal Structure of Ultralente--A Microcrystalline Insulin Suspension. Proteins, 74, 2009
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2VJZ
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![BU of 2vjz by Molmil](/molmil-images/mine/2vjz) | Crystal structure form ultalente insulin microcrystals | Descriptor: | CHLORIDE ION, INSULIN A CHAIN, INSULIN B CHAIN, ... | Authors: | Wagner, A, Diez, J, Schulze-Briese, C, Schluckebier, G. | Deposit date: | 2007-12-14 | Release date: | 2008-09-16 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of Ultralente-A Microcrystalline Insulin Suspension. Proteins, 74, 2009
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2R35
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![BU of 2r35 by Molmil](/molmil-images/mine/2r35) | |
2R36
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![BU of 2r36 by Molmil](/molmil-images/mine/2r36) | Crystal structure of ni human ARG-insulin | Descriptor: | CHLORIDE ION, Insulin, NICKEL (II) ION, ... | Authors: | Sreekanth, R, Pattabhi, V, Rajan, S.S. | Deposit date: | 2007-08-29 | Release date: | 2008-09-02 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Metal induced structural changes observed in hexameric insulin Int.J.Biol.Macromol., 44, 2009
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2R34
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![BU of 2r34 by Molmil](/molmil-images/mine/2r34) | |
2ZP6
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![BU of 2zp6 by Molmil](/molmil-images/mine/2zp6) | |
3BXQ
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![BU of 3bxq by Molmil](/molmil-images/mine/3bxq) | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition | Descriptor: | ZINC ION, insulin A chain, insulin B chain | Authors: | Wan, Z.L, Huang, K, Hu, S.Q, Whittaker, J, Weiss, M.A. | Deposit date: | 2008-01-14 | Release date: | 2008-05-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.3 Å) | Cite: | The structure of a mutant insulin uncouples receptor binding from protein allostery. An electrostatic block to the TR transition. J.Biol.Chem., 283, 2008
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