2ZPP

Neutron crystal structure of cubic insulin at pD9

Summary for 2ZPP

Related2EFA
DescriptorInsulin A chain, Insulin B chain (3 entities in total)
Functional Keywordshormone, cubic, porcine insulin, carbohydrate metabolism, cleavage on pair of basic residues, glucose metabolism, secreted
Biological sourceSus scrofa (Pig)
Cellular locationSecreted P01315 P01315
Total number of polymer chains2
Total molecular weight5787.63
Authors
Ishikawa, T.,Tanaka, I.,Niimura, N. (deposition date: 2008-07-26, release date: 2008-10-28, Last modification date: 2018-03-07)
Primary citation
Ishikawa, T.,Chatake, T.,Morimoto, Y.,Maeda, M.,Kurihara, K.,Tanaka, I.,Niimura, N.
An abnormal pK(a) value of internal histidine of the insulin molecule revealed by neutron crystallographic analysis
Biochem.Biophys.Res.Commun., 376:32-35, 2008
PubMed: 18725203 (PDB entries with the same primary citation)
DOI: 10.1016/j.bbrc.2008.08.071
MImport into Mendeley
Experimental method
NEUTRON DIFFRACTION (2.5 Å)
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers800MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution