Human insulin

Summary for 3I40

DescriptorInsulin A chain, Insulin B chain (3 entities in total)
Functional Keywordsinsulin, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, disulfide bond, glucose metabolism, hormone, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight5787.63
Timofeev, V.I.,Bezuglov, V.V.,Miroshnikov, K.A.,Chuprov-Netochin, R.N.,Kuranova, I.P. (deposition date: 2009-07-01, release date: 2010-01-05, Last modification date: 2014-04-16)
Primary citation
Timofeev, V.I.,Chuprov-Netochin, R.N.,Samigina, V.R.,Bezuglov, V.V.,Miroshnikov, K.A.,Kuranova, I.P.
X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66:259-263, 2010
PubMed: 20208155 (PDB entries with the same primary citation)
DOI: 10.1107/S1744309110000461
MImport into Mendeley
Experimental method
NMR Information

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.233604.4%2.0%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload