2RN5

Humal Insulin Mutant B31Lys-B32Arg

Summary for 2RN5

DescriptorInsulin (2 entities in total)
Functional Keywordshuman insulin mutant, 35% cd3cn, monomer, carbohydrate metabolism, cleavage on pair of basic residues, diabetes mellitus, disease mutation, glucose metabolism, hormone, pharmaceutical, secreted
Biological sourceHomo sapiens (human)
Cellular locationSecreted P01308 P01308
Total number of polymer chains2
Total molecular weight6104.02
Authors
Bocian, W.,Kozerski, L. (deposition date: 2007-12-06, release date: 2008-10-28, Last modification date: 2011-07-13)
Primary citation
Bocian, W.,Borowicz, P.,Sitkowski, J.,Tarnowska, A.,Bednarek, E.,Bogiel, M.,Kozerski, L.
NMR structure of biosynthetic engineered human insulin monomer B31(Lys)-B32(Arg) in water/acetonitrile solution. Comparison with the solution structure of native human insulin monomer
Biopolymers, 89:820-830, 2008
PubMed: 18491415 (PDB entries with the same primary citation)
DOI: 10.1002/bip.21018
MImport into Mendeley
Experimental method
SOLUTION NMR
NMR Information
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Structure validation

ClashscoreRamachandran outliersSidechain outliers01.0%2.4%MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all NMR structures
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