6QQG
 
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3E7Y
 | | Structure of human insulin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Timofeev, V.I, Baidus, A.N, Kislitsyn, Y.A, Kuranova, I.P. | | Deposit date: | 2008-08-19 | | Release date: | 2009-02-24 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of human insulin
to be published
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3E7Z
 | | Structure of human insulin | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Timofeev, V.I, Lyashenko, A.V, Kislitsyn, Y.A, Baidus, A.N, Kuranova, I.P. | | Deposit date: | 2008-08-19 | | Release date: | 2009-02-24 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Structure of human insulin
To be published
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8ONK
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8ONI
 | | Human insulin in complex with the analytical antibody S1 Fab | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Heavy chain of analytical antibody S1 Fab, Insulin A chain, ... | | Authors: | Johansson, E. | | Deposit date: | 2023-04-03 | | Release date: | 2024-04-10 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Macromolecular structure of insulin and IgE clonality impacts IgE-mediated activation of sensitized basophils
To Be Published
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6S34
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3FHP
 | | A neutron crystallographic analysis of a porcine 2Zn insulin at 2.0 A resolution | | Descriptor: | Insulin, ZINC ION | | Authors: | Iwai, W, Kurihara, K, Yamada, T, Kobayashi, Y, Ohnishi, Y, Tanaka, I, Takahashi, H, Niimura, N. | | Deposit date: | 2008-12-09 | | Release date: | 2009-10-20 | | Last modified: | 2023-11-01 | | Method: | NEUTRON DIFFRACTION (2 Å) | | Cite: | A neutron crystallographic analysis of T6 porcine insulin at 2.1 A resolution
Acta Crystallogr.,Sect.D, 65, 2009
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6S4J
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8PI4
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8PI5
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8PJH
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8PI6
 | | Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension | | Descriptor: | Insulin B chain,Insulin A chain | | Authors: | Johansson, E, Schluckebier, G. | | Deposit date: | 2023-06-21 | | Release date: | 2023-11-08 | | Last modified: | 2024-04-17 | | Method: | X-RAY DIFFRACTION (2.14 Å) | | Cite: | Molecular engineering of insulin for recombinant expression in yeast.
Trends Biotechnol, 42, 2024
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8PJC
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6S4I
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6RVA
 | | STRUCTURE OF [ASP58]-IGF-I ANALOGUE | | Descriptor: | Insulin-like growth factor I | | Authors: | Jiracek, J, Zakova, L, Socha, O. | | Deposit date: | 2019-05-31 | | Release date: | 2019-10-02 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Mutations at hypothetical binding site 2 in insulin and insulin-like growth factors 1 and 2 result in receptor- and hormone-specific responses.
J.Biol.Chem., 294, 2019
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3FQ9
 | | Design of an insulin analog with enhanced receptor-binding selectivity. Rationale, structure, and therapeutic implications | | Descriptor: | Insulin, ZINC ION | | Authors: | Zhao, M, Wan, Z.L, Whittaker, L, Xu, B, Phillips, N, Katsoyannis, P, Whittaker, J, Weiss, M.A. | | Deposit date: | 2009-01-07 | | Release date: | 2009-08-04 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Design of an insulin analog with enhanced receptor binding selectivity: rationale, structure, and therapeutic implications.
J.Biol.Chem., 284, 2009
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6TC2
 | | Monoclinic human insulin in complex with p-coumaric acid | | Descriptor: | 4'-HYDROXYCINNAMIC ACID, Insulin, PHOSPHATE ION, ... | | Authors: | Triandafillidis, D.-P, Parthenios, N, Spiliopoulou, M, Valmas, A, Kosinas, C, Gozzo, F, Reinle-Schmitt, M, Beckers, D, Degen, T, Pop, M, Fitch, A, Wollenhaupt, J, Weiss, M.S, Karavassili, F, Margiolaki, I. | | Deposit date: | 2019-11-04 | | Release date: | 2020-11-11 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.36 Å) | | Cite: | Insulin polymorphism induced by two polyphenols: new crystal forms and advances in macromolecular powder diffraction.
Acta Crystallogr D Struct Biol, 76, 2020
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8SBD
 | | Cryo-EM structure of insulin amyloid-like fibril that is composed of two antiparallel protofilaments | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Wang, L.W, Hall, C, Uchikawa, E, Chen, D.L, Choi, E, Zhang, X.W, Bai, X.C. | | Deposit date: | 2023-04-03 | | Release date: | 2023-08-30 | | Last modified: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structural basis of insulin fibrillation.
Sci Adv, 9, 2023
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3EXX
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3GF1
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3GKY
 | | The Structural Basis of an ER Stress-Associated Bottleneck in a Protein Folding Landscape | | Descriptor: | CHLORIDE ION, Insulin A chain, Insulin B chain, ... | | Authors: | Liu, M, Wan, Z.L, Chu, Y.C, Alddin, H, Klaproth, B, Weiss, M.A. | | Deposit date: | 2009-03-11 | | Release date: | 2009-03-24 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystal structure of a "nonfoldable" insulin: IMPAIRED FOLDING EFFICIENCY DESPITE NATIVE ACTIVITY.
J.Biol.Chem., 284, 2009
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3I40
 | | Human insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Chuprov-Netochin, R.N, Kuranova, I.P. | | Deposit date: | 2009-07-01 | | Release date: | 2010-01-05 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66, 2010
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3I3Z
 | | Human insulin | | Descriptor: | Insulin A chain, Insulin B chain | | Authors: | Timofeev, V.I, Bezuglov, V.V, Miroshnikov, K.A, Cuprov-Netochin, R.N, Samigina, V.R, Kuranova, I.P. | | Deposit date: | 2009-07-01 | | Release date: | 2010-01-05 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | X-ray investigation of gene-engineered human insulin crystallized from a solution containing polysialic acid.
Acta Crystallogr.,Sect.F, 66, 2010
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3INC
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3INS
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