3GF1

SOLUTION STRUCTURE OF HUMAN INSULIN-LIKE GROWTH FACTOR 1: A NUCLEAR MAGNETIC RESONANCE AND RESTRAINED MOLECULAR DYNAMICS STUDY

Summary for 3GF1

Entry DOI	10.2210/pdb3gf1/pdb
Descriptor	INSULIN-LIKE GROWTH FACTOR I (1 entity in total)
Functional Keywords	growth factor
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	7663.75
Authors	Cooke, R.M.,Harvey, T.S.,Campbell, I.D. (deposition date: 1991-01-24, release date: 1993-04-15, Last modification date: 2024-10-23)
Primary citation	Cooke, R.M.,Harvey, T.S.,Campbell, I.D. Solution structure of human insulin-like growth factor 1: a nuclear magnetic resonance and restrained molecular dynamics study. Biochemistry, 30:5484-5491, 1991 Cited by PubMed Abstract: The solution structure of human insulin-like growth factor 1 has been investigated with a combination of nuclear magnetic resonance and restrained molecular dynamics methods. The results show that the solution structure is similar to that of insulin, but minor differences exist. The regions homologous to insulin are well-defined, while the remainder of the molecule exhibits greater disorder. The resultant structures have been used to visualize the sites for interaction with a number of physiologically important proteins. PubMed: 2036417 DOI: 10.1021/bi00236a022 PDB entries with the same primary citation
Experimental method	SOLUTION NMR

Structure validation