8PI6

Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension

Summary for 8PI6

• Entry DOI: 10.2210/pdb8pi6/pdb
• Descriptor: Insulin B chain,Insulin A chain (2 entities in total)
• Functional Keywords: insulin, precursor, dimer, hormone
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 5
• Total formula weight: 36981.35

Authors

Johansson, E.,Schluckebier, G. (deposition date: 2023-06-21, release date: 2023-11-08, Last modification date: 2024-04-17)

• Primary citation: Kjeldsen, T.,Andersen, A.S.,Hubalek, F.,Johansson, E.,Kreiner, F.F.,Schluckebier, G.,Kurtzhals, P.; Molecular engineering of insulin for recombinant expression in yeast.; Trends Biotechnol, 42:464-478, 2024; PubMed: 37880066; DOI: 10.1016/j.tibtech.2023.09.012

Experimental method

X-RAY DIFFRACTION (2.14 Å)