8PI6
Crystal structure of the monomeric zinc free human insulin A22K, B3E, B26E, B29R, desB30 precursor with a Ser-Glu-Asp-Trp-Trp-Arg C-peptide and a Glu-Glu-Gly-Glu-Pro-Arg N-terminal extension
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B, C, D, E | Insulin B chain,Insulin A chain | polymer | 63 | 7396.3 | 5 | UniProt (P01308) Pfam (PF00049) In PDB | Homo sapiens (human) | |
2 | water | water | 18.0 | 16 | Chemie (HOH) |
Sequence modifications
A, B, C, D, E: 1 - 29 (UniProt: P01308)
A, B, C, D, E: 36 - 56 (UniProt: P01308)
PDB | External Database | Details |
---|---|---|
Glu -5 | - | expression tag |
Glu -4 | - | expression tag |
Gly -3 | - | expression tag |
Glu -2 | - | expression tag |
Pro -1 | - | expression tag |
Arg 0 | - | expression tag |
Glu 3 | Asn 27 | engineered mutation |
Glu 26 | Tyr 50 | engineered mutation |
Arg 29 | Lys 53 | engineered mutation |
PDB | External Database | Details |
---|---|---|
Ser 30 | - | linker |
Glu 31 | - | linker |
Asp 32 | - | linker |
Trp 33 | - | linker |
Trp 34 | - | linker |
Arg 35 | - | linker |
Lys 57 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 5 |
Total formula weight | 36981.4 | |
All* | Total formula weight | 36981.4 |