5JCS
 
 | | CRYO-EM STRUCTURE OF THE RIX1-REA1 PRE-60S PARTICLE | | Descriptor: | 25S ribosomal RNA, 5.8S ribosomal RNA, 5S ribosomal RNA, ... | | Authors: | Barrio-Garcia, C, Thoms, M, Flemming, D, Kater, L, Berninghausen, O, Bassler, J, Beckmann, R, Hurt, E. | | Deposit date: | 2016-04-15 | | Release date: | 2016-11-16 | | Last modified: | 2024-07-10 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Architecture of the Rix1-Rea1 checkpoint machinery during pre-60S-ribosome remodeling
Nat.Struct.Mol.Biol., 23, 2016
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5JUO
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure I (fully rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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5IT7
 | | Structure of the Kluyveromyces lactis 80S ribosome in complex with the cricket paralysis virus IRES and eEF2 | | Descriptor: | (2S)-1-amino-N,N,N-trimethyl-1-oxobutan-2-aminium, 18S ribosomal RNA, 25S ribosomal RNA, ... | | Authors: | Murray, J, Savva, C.G, Shin, B.S, Dever, T.E, Ramakrishnan, V, Fernandez, I.S. | | Deposit date: | 2016-03-16 | | Release date: | 2016-05-18 | | Last modified: | 2018-11-21 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structural characterization of ribosome recruitment and translocation by type IV IRES.
Elife, 5, 2016
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5K0Y
 | | m48S late-stage initiation complex, purified from rabbit reticulocytes lysates, displaying eIF2 ternary complex and eIF3 i and g subunits relocated to the intersubunit face | | Descriptor: | 18S ribosomal RNA, 40S ribosomal protein S12, 40S ribosomal protein S21, ... | | Authors: | Simonetti, A, Brito Querido, J, Myasnikov, A.G, Mancera-Martinez, E, Renaud, A, Kuhn, L, Hashem, Y. | | Deposit date: | 2016-05-17 | | Release date: | 2016-07-13 | | Last modified: | 2018-04-18 | | Method: | ELECTRON MICROSCOPY (5.8 Å) | | Cite: | eIF3 Peripheral Subunits Rearrangement after mRNA Binding and Start-Codon Recognition.
Mol.Cell, 63, 2016
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5JUU
 | | Saccharomyces cerevisiae 80S ribosome bound with elongation factor eEF2-GDP-sordarin and Taura Syndrome Virus IRES, Structure V (least rotated 40S subunit) | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Abeyrathne, P, Koh, C.S, Grant, T, Grigorieff, N, Korostelev, A.A. | | Deposit date: | 2016-05-10 | | Release date: | 2016-10-05 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Ensemble cryo-EM uncovers inchworm-like translocation of a viral IRES through the ribosome.
Elife, 5, 2016
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5KHR
 | | Model of human Anaphase-promoting complex/Cyclosome complex (APC15 deletion mutant) in complex with the E2 UBE2C/UBCH10 poised for ubiquitin ligation to substrate (APC/C-CDC20-substrate-UBE2C) | | Descriptor: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | Authors: | VanderLinden, R, Yamaguchi, M, Dube, P, Haselbach, D, Stark, H, Schulman, B.A. | | Deposit date: | 2016-06-15 | | Release date: | 2016-08-24 | | Last modified: | 2024-03-06 | | Method: | ELECTRON MICROSCOPY (6.1 Å) | | Cite: | Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation.
Mol.Cell, 63, 2016
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5L8W
 | | Structure of USP12-UB-PRG/UAF1 | | Descriptor: | GLYCEROL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 12, ... | | Authors: | Dharadhar, S, Sixma, T. | | Deposit date: | 2016-06-08 | | Release date: | 2016-09-28 | | Last modified: | 2016-11-30 | | Method: | X-RAY DIFFRACTION (2.79 Å) | | Cite: | A conserved two-step binding for the UAF1 regulator to the USP12 deubiquitinating enzyme.
J.Struct.Biol., 196, 2016
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5UKM
 | | bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as) | | Descriptor: | 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cruz-Rodriguez, O, Tesmer, J.J.G. | | Deposit date: | 2017-01-23 | | Release date: | 2017-04-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (3.03 Å) | | Cite: | Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
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5TGA
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5TGM
 | | Crystal structure of the S.cerevisiae 80S ribosome in complex with the A-site bound aminoacyl-tRNA analog ACCA-Pro | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 3'-amino-3'-deoxyadenosine 5'-(dihydrogen phosphate), ... | | Authors: | Melnikov, S, Mailliot, J, Yusupov, M. | | Deposit date: | 2016-09-28 | | Release date: | 2017-01-18 | | Last modified: | 2022-12-07 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Molecular insights into protein synthesis with proline residues.
EMBO Rep., 17, 2016
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5TBW
 | | Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome | | Descriptor: | 18S ribosomal RNA, 25S ribosomal RNA, 40S ribosomal protein S0-A, ... | | Authors: | Konst, Z.A, Szklarski, A.R, Pellegrino, S, Michalak, S.E, Meyer, M, Zanette, C, Cencic, R, Nam, S, Horne, D.A, Pelletier, J, Mobley, D.L, Yusupova, G, Yusupov, M, Vanderwal, C.D. | | Deposit date: | 2016-09-13 | | Release date: | 2017-07-26 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9, 2017
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5T2A
 | | CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution | | Descriptor: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | | Deposit date: | 2016-08-23 | | Release date: | 2017-01-25 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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5TZS
 | | Architecture of the yeast small subunit processome | | Descriptor: | 13 kDa ribonucleoprotein-associated protein, 18S ribosomal RNA, 3' domain-associated, ... | | Authors: | Chaker-Margot, M, Barandun, J, Hunziker, M, Klinge, S. | | Deposit date: | 2016-11-22 | | Release date: | 2016-12-21 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (5.1 Å) | | Cite: | Architecture of the yeast small subunit processome.
Science, 355, 2017
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5T2C
 | | CryoEM structure of the human ribosome at 3.6 Angstrom resolution | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | | Deposit date: | 2016-08-23 | | Release date: | 2017-01-25 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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5VAI
 | | Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein | | Descriptor: | Glucagon-like peptide 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Zhang, Y, Sun, B, Feng, D, Hu, H, Chu, M, Qu, Q, Tarrasch, J.T, Li, S, Kobilka, T.S, Kobilka, B.K, Skiniotis, G. | | Deposit date: | 2017-03-27 | | Release date: | 2017-05-24 | | Last modified: | 2019-12-18 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.
Nature, 546, 2017
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5UKL
 | | Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd) | | Descriptor: | 2-{5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluorophenyl}-N-[2-(1H-pyrazol-4-yl)ethyl]acetamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cato, M.C, Homan, K.T, Tesmer, J.J.G. | | Deposit date: | 2017-01-23 | | Release date: | 2017-04-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.15 Å) | | Cite: | Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
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5VYC
 | | Crystal structure of the human 40S ribosomal subunit in complex with DENR-MCT-1. | | Descriptor: | 40S ribosomal protein S10, 40S ribosomal protein S11, 40S ribosomal protein S12, ... | | Authors: | Lomakin, I.B, Stolboushkina, E.A, Vaidya, A.T, Garber, M.B, Dmitriev, S.E, Steitz, T.A. | | Deposit date: | 2017-05-24 | | Release date: | 2017-07-19 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (6 Å) | | Cite: | Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1.
Cell Rep, 20, 2017
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5UKK
 | | Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak) | | Descriptor: | 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(pyridin-2-yl)methyl]benzamide, Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | | Authors: | Cato, M.C, Homan, K.T, Tesmer, J.J.G. | | Deposit date: | 2017-01-23 | | Release date: | 2017-04-05 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.
J. Med. Chem., 60, 2017
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5UZ7
 | | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | | Descriptor: | Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | | Authors: | Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M. | | Deposit date: | 2017-02-24 | | Release date: | 2017-05-03 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.
Nature, 546, 2017
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3J7R
 | | Structure of the translating mammalian ribosome-Sec61 complex | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. | | Deposit date: | 2014-08-01 | | Release date: | 2014-09-03 | | Last modified: | 2019-10-30 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
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3J2T
 | | An improved model of the human apoptosome | | Descriptor: | ADENOSINE-5'-TRIPHOSPHATE, Apoptotic protease-activating factor 1, Cytochrome c, ... | | Authors: | Yuan, S, Topf, M, Akey, C.W. | | Deposit date: | 2012-12-23 | | Release date: | 2013-04-10 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (9.5 Å) | | Cite: | Changes in apaf-1 conformation that drive apoptosome assembly.
Biochemistry, 52, 2013
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3JAH
 | | Structure of a mammalian ribosomal termination complex with ABCE1, eRF1(AAQ), and the UAG stop codon | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Brown, A, Shao, S, Murray, J, Hegde, R.S, Ramakrishnan, V. | | Deposit date: | 2015-06-10 | | Release date: | 2015-08-12 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.45 Å) | | Cite: | Structural basis for stop codon recognition in eukaryotes.
Nature, 524, 2015
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3JCR
 | | 3D structure determination of the human*U4/U6.U5* tri-snRNP complex | | Descriptor: | LSm2, LSm3, LSm4, ... | | Authors: | Agafonov, D.E, Kastner, B, Dybkov, O, Hofele, R.V, Liu, W.T, Urlaub, H, Luhrmann, R, Stark, H. | | Deposit date: | 2016-01-21 | | Release date: | 2016-03-09 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (7 Å) | | Cite: | Molecular architecture of the human U4/U6.U5 tri-snRNP.
Science, 351, 2016
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3JCT
 | | Cryo-em structure of eukaryotic pre-60S ribosomal subunits | | Descriptor: | 60S ribosomal protein L11-A, 60S ribosomal protein L13-A, 60S ribosomal protein L14-A, ... | | Authors: | Wu, S, Kumcuoglu, B, Yan, K.G, Brown, H, Zhang, Y.X, Tan, D, Gamalinda, M, Yuan, Y, Li, Z.F, Jakovljevic, J, Ma, C.Y, Lei, J.L, Dong, M.Q, Woolford Jr, J.L, Gao, N. | | Deposit date: | 2016-03-09 | | Release date: | 2016-06-01 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (3.08 Å) | | Cite: | Diverse roles of assembly factors revealed by structures of late nuclear pre-60S ribosomes
Nature, 534, 2016
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3J7P
 | | Structure of the 80S mammalian ribosome bound to eEF2 | | Descriptor: | 18S ribosomal RNA, 28S ribosomal RNA, 5.8S ribosomal RNA, ... | | Authors: | Voorhees, R.M, Fernandez, I.S, Scheres, S.H.W, Hegde, R.S. | | Deposit date: | 2014-08-01 | | Release date: | 2014-09-03 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157, 2014
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