Crystal structure of chlorolissoclimide bound to the yeast 80S ribosome

This is a large structure.

Summary for 5TBW

Descriptor25S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (87 entities in total)
Functional Keywordsprotein translation inhibitor, complex, ribosome
Biological sourceSaccharomyces cerevisiae (strain ATCC 204508 / S288c)
Total number of polymer chains159
Total molecular weight6294772.15
Primary citation
Konst, Z.A.,Szklarski, A.R.,Pellegrino, S.,Michalak, S.E.,Meyer, M.,Zanette, C.,Cencic, R.,Nam, S.,Voora, V.K.,Horne, D.A.,Pelletier, J.,Mobley, D.L.,Yusupova, G.,Yusupov, M.,Vanderwal, C.D.
Synthesis facilitates an understanding of the structural basis for translation inhibition by the lissoclimides.
Nat Chem, 9:1140-1149, 2017
PubMed: 29064494 (PDB entries with the same primary citation)
DOI: 10.1038/nchem.2800
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliersRNA backbone0.228100.9%13.9%5.4%0.53MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5tbw
no rotation
Molmil generated image of 5tbw
rotated about x axis by 90°
Molmil generated image of 5tbw
rotated about y axis by 90°