5UKM

bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)

Summary for 5UKM

Entry DOI	10.2210/pdb5ukm/pdb
Descriptor	Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (7 entities in total)
Functional Keywords	kinase, inhibitor complex, transferase-signaling protein complex, transferase/signaling protein
Biological source	Bos taurus (Bovine) More
Total number of polymer chains	3
Total formula weight	127585.99
Authors	Cruz-Rodriguez, O.,Tesmer, J.J.G. (deposition date: 2017-01-23, release date: 2017-04-12, Last modification date: 2023-10-04)
Primary citation	Waldschmidt, H.V.,Homan, K.T.,Cato, M.C.,Cruz-Rodriguez, O.,Cannavo, A.,Wilson, M.W.,Song, J.,Cheung, J.Y.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60:3052-3069, 2017 Cited by PubMed: 28323425 DOI: 10.1021/acs.jmedchem.7b00112 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.03 Å)

Structure validation