5UKM
bovine GRK2 in complex with human Gbetagamma subunits and CCG258208 (14as)
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Beta-adrenergic receptor kinase 1 | polymer | 695 | 80578.8 | 1 | UniProt (P21146) Pfam (PF00615) Pfam (PF00069) Pfam (PF00169) In PDB | Bos taurus (Bovine) | Beta-ARK-1,G-protein-coupled receptor kinase 2 |
2 | B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | polymer | 350 | 38534.1 | 1 | UniProt (P62873) Pfam (PF00400) In PDB | Homo sapiens (Human) | Transducin beta chain 1 |
3 | G | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | polymer | 71 | 7861.1 | 1 | UniProt (P59768) Pfam (PF00631) In PDB | Homo sapiens (Human) | G gamma-I |
4 | A | 5-[(3S,4R)-3-{[(2H-1,3-benzodioxol-5-yl)oxy]methyl}piperidin-4-yl]-2-fluoro-N-[(1H-pyrazol-5-yl)methyl]benzamide | non-polymer | 452.5 | 1 | Chemie (T0E) | |||
5 | A | MAGNESIUM ION | non-polymer | 24.3 | 1 | Chemie (MG) | |||
6 | G | O-METHYLCYSTEINE | non-polymer | 135.2 | 1 | Chemie (CMT) | |||
7 | water | water | 18.0 | 23 | Chemie (HOH) |
Sequence modifications
A: 1 - 689 (UniProt: P21146)
B: 2 - 340 (UniProt: P62873)
PDB | External Database | Details |
---|---|---|
Ala 670 | Ser 670 | engineered mutation |
His 690 | - | expression tag |
His 691 | - | expression tag |
His 692 | - | expression tag |
His 693 | - | expression tag |
His 694 | - | expression tag |
His 695 | - | expression tag |
PDB | External Database | Details |
---|---|---|
Met -9 | - | expression tag |
His -8 | - | expression tag |
His -7 | - | expression tag |
His -6 | - | expression tag |
His -5 | - | expression tag |
His -4 | - | expression tag |
His -3 | - | expression tag |
Gly -2 | - | expression tag |
Ser -1 | - | expression tag |
Ser 0 | - | expression tag |
Gly 1 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 126974.0 | |
Non-Polymers* | Number of molecules | 3 |
Total formula weight | 612.0 | |
All* | Total formula weight | 127586.0 |