5UKL
Human GRK2 in complex with Gbetagamma subunits and CCG222886 (14bd)
Summary for 5UKL
Entry DOI | 10.2210/pdb5ukl/pdb |
Related | 5UKK |
Descriptor | Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total) |
Functional Keywords | kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 3 |
Total formula weight | 119535.61 |
Authors | Cato, M.C.,Homan, K.T.,Tesmer, J.J.G. (deposition date: 2017-01-23, release date: 2017-04-05, Last modification date: 2023-10-04) |
Primary citation | Waldschmidt, H.V.,Homan, K.T.,Cato, M.C.,Cruz-Rodriguez, O.,Cannavo, A.,Wilson, M.W.,Song, J.,Cheung, J.Y.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D. Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine. J. Med. Chem., 60:3052-3069, 2017 Cited by PubMed: 28323425DOI: 10.1021/acs.jmedchem.7b00112 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.15 Å) |
Structure validation
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