5UKK

Human GRK2 in complex with human G-beta-gamma subunits and CCG211998 (14ak)

Summary for 5UKK

• Entry DOI: 10.2210/pdb5ukk/pdb
• Related: 5UKL
• Descriptor: Beta-adrenergic receptor kinase 1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... (6 entities in total)
• Functional Keywords: kinase, inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 3
• Total formula weight: 118920.83

Authors

Cato, M.C.,Homan, K.T.,Tesmer, J.J.G. (deposition date: 2017-01-23, release date: 2017-04-05, Last modification date: 2023-10-04)

• Primary citation: Waldschmidt, H.V.,Homan, K.T.,Cato, M.C.,Cruz-Rodriguez, O.,Cannavo, A.,Wilson, M.W.,Song, J.,Cheung, J.Y.,Koch, W.J.,Tesmer, J.J.,Larsen, S.D.; Structure-Based Design of Highly Selective and Potent G Protein-Coupled Receptor Kinase 2 Inhibitors Based on Paroxetine.; J. Med. Chem., 60:3052-3069, 2017; PubMed: 28323425; DOI: 10.1021/acs.jmedchem.7b00112

Experimental method

X-RAY DIFFRACTION (2.6 Å)