7V98
 
 | | Crystal Structure of the Dimeric EcHsp60 | | Descriptor: | 60 kDa chaperonin | | Authors: | Lai, M.C, Lin, S.M. | | Deposit date: | 2021-08-24 | | Release date: | 2022-08-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation.
Life Sci Alliance, 6, 2023
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7V9R
 | | Crystal Structure of the heptameric EcHsp60 | | Descriptor: | 60 kDa chaperonin | | Authors: | Lai, M.C, Lin, S.M. | | Deposit date: | 2021-08-26 | | Release date: | 2022-08-31 | | Last modified: | 2023-11-29 | | Method: | X-RAY DIFFRACTION (3.5 Å) | | Cite: | Crystal structures of dimeric and heptameric mtHsp60 reveal the mechanism of chaperonin inactivation.
Life Sci Alliance, 6, 2023
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4M8V
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2UZR
 | | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | | Descriptor: | RAC-alpha serine/threonine-protein kinase | | Authors: | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | | Deposit date: | 2007-05-01 | | Release date: | 2007-07-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.94 Å) | | Cite: | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Nature, 448, 2007
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2UZS
 | | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K) | | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, RAC-alpha serine/threonine-protein kinase | | Authors: | Carpten, J.D, Faber, A.L, Horn, C, Donoho, G.P, Briggs, S.L, Robbins, C.M, Hostetter, G, Boguslawski, S, Moses, T.Y, Savage, S, Uhlik, M, Lin, A, Du, J, Qian, Y.W, Zeckner, D.J, Tucker-Kellogg, G, Touchman, J, Patel, K, Mousses, S, Bittner, M, Schevitz, R, Lai, M.H, Blanchard, K.L, Thomas, J.E. | | Deposit date: | 2007-05-01 | | Release date: | 2007-07-17 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.46 Å) | | Cite: | A transforming mutation in the pleckstrin homology domain of AKT1 in cancer.
Nature, 448, 2007
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5H02
 | | Crystal structure of Methanohalophilus portucalensis glycine sarcosine N-methyltransferase tetramutant (H21G, E23T, E24N, L28S) | | Descriptor: | Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, TRIMETHYL GLYCINE | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-10-02 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.776 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
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5HIL
 | | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and sarcosine | | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ... | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.471 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
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5HIK
 | | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine | | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.354 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
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5HIM
 | | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine | | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, N,N-DIMETHYLGLYCINE, ... | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (2.338 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
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5GWX
 | | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylmethionine and sarcosine | | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase, S-ADENOSYLMETHIONINE, ... | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-09-14 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (2.205 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity.
Sci Rep, 6, 2016
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5HIJ
 | | Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with betaine | | Descriptor: | Glycine sarcosine N-methyltransferase, TRIMETHYL GLYCINE | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-15 | | Method: | X-RAY DIFFRACTION (1.93 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
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5HII
 | | Crystal structure of glycine sarcosine N-methyltransferase (GSMT) from Methanohalophilus portucalensis (apo form) | | Descriptor: | 1,2-ETHANEDIOL, Glycine sarcosine N-methyltransferase | | Authors: | Lee, Y.R, Lin, T.S, Lai, S.J, Liu, M.S, Lai, M.C, Chan, N.L. | | Deposit date: | 2016-01-12 | | Release date: | 2016-11-23 | | Last modified: | 2023-11-08 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity
Sci Rep, 6, 2016
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7MRW
 | | Native RhopH complex of the malaria parasite Plasmodium falciparum | | Descriptor: | Cytoadherence linked asexual protein 3.1, High molecular weight rhoptry protein 2, High molecular weight rhoptry protein 3 | | Authors: | Ho, C.M, Jih, J, Lai, M, Li, X.R, Goldberg, D.E, Beck, J.R, Zhou, Z.H. | | Deposit date: | 2021-05-10 | | Release date: | 2021-09-15 | | Method: | ELECTRON MICROSCOPY (3.72 Å) | | Cite: | Native structure of the RhopH complex, a key determinant of malaria parasite nutrient acquisition.
Proc.Natl.Acad.Sci.USA, 118, 2021
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6E10
 | | PTEX Core Complex in the Engaged (Extended) State | | Descriptor: | Endogenous cargo polypeptide, Exported protein 2, Heat shock protein 101, ... | | Authors: | Ho, C, Lai, M, Zhou, Z.H. | | Deposit date: | 2018-07-08 | | Release date: | 2018-08-22 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4.16 Å) | | Cite: | Malaria parasite translocon structure and mechanism of effector export.
Nature, 561, 2018
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6E11
 | | PTEX Core Complex in the Resetting (Compact) State | | Descriptor: | Endogenous cargo polypeptide, Exported protein 2, Heat shock protein 101, ... | | Authors: | Ho, C, Lai, M, Zhou, Z.H. | | Deposit date: | 2018-07-08 | | Release date: | 2018-08-22 | | Last modified: | 2019-11-27 | | Method: | ELECTRON MICROSCOPY (4.23 Å) | | Cite: | Malaria parasite translocon structure and mechanism of effector export.
Nature, 561, 2018
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6PEV
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6N9Y
 | | Atomic structure of Non-Structural protein 1 of bluetongue virus | | Descriptor: | Non-structural protein 1 | | Authors: | Kerviel, A, Ge, P, Lai, M, Jih, J, Boyce, M, Zhang, X, Zhou, Z.H, Roy, P. | | Deposit date: | 2018-12-04 | | Release date: | 2019-03-13 | | Last modified: | 2024-03-20 | | Method: | ELECTRON MICROSCOPY (4 Å) | | Cite: | Atomic structure of the translation regulatory protein NS1 of bluetongue virus.
Nat Microbiol, 4, 2019
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6PEW
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2B8V
 | | Crystal structure of human Beta-secretase complexed with L-L000430,469 | | Descriptor: | 3-BENZOYL-N-[(1S,2R)-1-BENZYL-3-(CYCLOPROPYLAMINO)-2-HYDROXYPROPYL]-5-[METHYL(METHYLSULFONYL)AMINO]BENZAMIDE, Beta-secretase 1 | | Authors: | Stachel, S.J, Coburn, C.A, Steele, T.G, Crouthamel, M.-C, Pietrak, B.L, Lai, M.-T, Holloway, M.K, Munshi, S.K, Graham, S.L, Vacca, J.P. | | Deposit date: | 2005-10-10 | | Release date: | 2005-12-06 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Conformationally biased P3 amide replacements of beta-secretase inhibitors.
Bioorg.Med.Chem.Lett., 16, 2006
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4M9O
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5T2A
 | | CryoEM structure of the Leishmania donovani 80S ribosome at 2.9 Angstrom resolution | | Descriptor: | 18S rRNA, 5.8S rRNA, 5S rRNA, ... | | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | | Deposit date: | 2016-08-23 | | Release date: | 2017-01-25 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (2.9 Å) | | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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5T2C
 | | CryoEM structure of the human ribosome at 3.6 Angstrom resolution | | Descriptor: | 18S rRNA, 28S rRNA, 40S ribosomal protein S10, ... | | Authors: | Zhang, X, Lai, M, Zhou, Z.H. | | Deposit date: | 2016-08-23 | | Release date: | 2017-01-25 | | Last modified: | 2023-08-16 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | Structures and stabilization of kinetoplastid-specific split rRNAs revealed by comparing leishmanial and human ribosomes.
Nat Commun, 7, 2016
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5TC1
 | | In situ structures of the genome and genome-delivery apparatus in ssRNA bacteriophage MS2 | | Descriptor: | Capsid protein, Maturation protein, phage MS2 genome | | Authors: | Dai, X.H, Li, Z.H, Lai, M, Shu, S, Du, Y.S, Zhou, Z.H, Sun, R. | | Deposit date: | 2016-09-13 | | Release date: | 2016-12-07 | | Last modified: | 2018-07-18 | | Method: | ELECTRON MICROSCOPY (3.6 Å) | | Cite: | In situ structures of the genome and genome-delivery apparatus in a single-stranded RNA virus.
Nature, 541, 2017
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6BP7
 | | Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 2 | | Descriptor: | Major vault protein | | Authors: | Ding, K, Zhang, X, Mrazek, J, Kickhoefer, V.A, Lai, M, Ng, H.L, Yang, O.O, Rome, L.H, Zhou, Z.H. | | Deposit date: | 2017-11-22 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
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6BP8
 | | Recombinant major vault protein [Rattus norvegicus] structure in solution: conformation 1 | | Descriptor: | Major vault protein | | Authors: | Ding, K, Zhang, X, Mrazek, J, Kickhoefer, V.A, Lai, M, Ng, H.L, Yang, O.O, Rome, L.H, Zhou, Z.H. | | Deposit date: | 2017-11-22 | | Release date: | 2018-04-04 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (4.9 Å) | | Cite: | Solution Structures of Engineered Vault Particles.
Structure, 26, 2018
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