5HIM

Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine

Summary for 5HIM

Entry DOI	10.2210/pdb5him/pdb
Related	5GWX 5H02 5HII 5HIJ 5HIK 5HIL
Descriptor	Glycine sarcosine N-methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, N,N-DIMETHYLGLYCINE, ... (5 entities in total)
Functional Keywords	s-adenosylmethionine-dependent methyltransferases (sam or adomet-mtase), class i, monomethylation of glycine and sarcosine, rate-limiting enzyme in betaine biosynthesis, betaine-mediated feedback inhibition, transferase
Biological source	Methanohalophilus portucalensis FDF-1
Total number of polymer chains	1
Total formula weight	33660.23
Authors	Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. (deposition date: 2016-01-12, release date: 2016-11-23, Last modification date: 2023-11-15)
Primary citation	Lee, Y.R.,Lin, T.S.,Lai, S.J.,Liu, M.S.,Lai, M.C.,Chan, N.L. Structural Analysis of Glycine Sarcosine N-methyltransferase from Methanohalophilus portucalensis Reveals Mechanistic Insights into the Regulation of Methyltransferase Activity Sci Rep, 6:38071-38071, 2016 Cited by PubMed: 27934872 DOI: 10.1038/srep38071 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.338 Å)

Structure validation