5HIM
Crystal structure of glycine sarcosine N-methyltransferase from Methanohalophilus portucalensis in complex with S-adenosylhomocysteine and dimethylglycine
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005829 | cellular_component | cytosol |
| A | 0006111 | biological_process | regulation of gluconeogenesis |
| A | 0006730 | biological_process | one-carbon metabolic process |
| A | 0008168 | molecular_function | methyltransferase activity |
| A | 0016594 | molecular_function | glycine binding |
| A | 0016740 | molecular_function | transferase activity |
| A | 0017174 | molecular_function | glycine N-methyltransferase activity |
| A | 0032259 | biological_process | methylation |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046498 | biological_process | S-adenosylhomocysteine metabolic process |
| A | 0046500 | biological_process | S-adenosylmethionine metabolic process |
| A | 0051289 | biological_process | protein homotetramerization |
| A | 1901052 | biological_process | sarcosine metabolic process |
| A | 1904047 | molecular_function | S-adenosyl-L-methionine binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 18 |
| Details | binding site for residue SAH A 301 |
| Chain | Residue |
| A | ARG43 |
| A | TRP115 |
| A | ARG116 |
| A | LEU132 |
| A | GLY133 |
| A | SER135 |
| A | EDO306 |
| A | HOH419 |
| A | HOH435 |
| A | HOH440 |
| A | ALA67 |
| A | GLY69 |
| A | ASN73 |
| A | ASP88 |
| A | GLY89 |
| A | MET93 |
| A | ALA113 |
| A | ASP114 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue DMG A 302 |
| Chain | Residue |
| A | GLY133 |
| A | ASN134 |
| A | HIS138 |
| A | ARG167 |
| A | TYR206 |
| A | MET218 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 303 |
| Chain | Residue |
| A | GLU47 |
| A | ILE51 |
| A | ILE52 |
| A | ASN73 |
| site_id | AC4 |
| Number of Residues | 4 |
| Details | binding site for residue EDO A 304 |
| Chain | Residue |
| A | ALA44 |
| A | ARG76 |
| A | GLN79 |
| A | HIS104 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 305 |
| Chain | Residue |
| A | TRP40 |
| A | ASN100 |
| A | HIS104 |
| A | HOH405 |
| A | HOH409 |
| site_id | AC6 |
| Number of Residues | 7 |
| Details | binding site for residue EDO A 306 |
| Chain | Residue |
| A | TRP34 |
| A | ASP35 |
| A | ARG43 |
| A | THR70 |
| A | SAH301 |
| A | HOH419 |
| A | HOH445 |
| site_id | AC7 |
| Number of Residues | 5 |
| Details | binding site for residue EDO A 307 |
| Chain | Residue |
| A | ARG167 |
| A | ASN168 |
| A | ILE172 |
| A | HIS183 |
| A | ASP254 |
| site_id | AC8 |
| Number of Residues | 3 |
| Details | binding site for residue EDO A 308 |
| Chain | Residue |
| A | ASP188 |
| A | TYR248 |
| A | HOH407 |
Functional Information from PROSITE/UniProt
| site_id | PS00012 |
| Number of Residues | 16 |
| Details | PHOSPHOPANTETHEINE Phosphopantetheine attachment site. GTGFNSVRLLQAGFDV |
| Chain | Residue | Details |
| A | GLY69-VAL84 |
