2UZR

A transforming mutation in the pleckstrin homology domain of AKT1 in cancer (AKT1-PH_E17K)

Summary for 2UZR

Entry DOI	10.2210/pdb2uzr/pdb
Related	1H10 1UNP 1UNQ 1UNR 2UVM 2UZS
Descriptor	RAC-alpha serine/threonine-protein kinase (2 entities in total)
Functional Keywords	transferase, glycogen biosynthesis, translation regulation, nucleotide- binding, glycogen metabolism, atp-binding, sugar transport, nuclear protein, serine/threonine-protein kinase, transport, carbohydrate metabolism, kinase, apoptosis, phosphorylation, glucose metabolism
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	14773.73
Authors	Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E. (deposition date: 2007-05-01, release date: 2007-07-17, Last modification date: 2023-12-13)
Primary citation	Carpten, J.D.,Faber, A.L.,Horn, C.,Donoho, G.P.,Briggs, S.L.,Robbins, C.M.,Hostetter, G.,Boguslawski, S.,Moses, T.Y.,Savage, S.,Uhlik, M.,Lin, A.,Du, J.,Qian, Y.W.,Zeckner, D.J.,Tucker-Kellogg, G.,Touchman, J.,Patel, K.,Mousses, S.,Bittner, M.,Schevitz, R.,Lai, M.H.,Blanchard, K.L.,Thomas, J.E. A transforming mutation in the pleckstrin homology domain of AKT1 in cancer. Nature, 448:439-444, 2007 Cited by PubMed: 17611497 DOI: 10.1038/nature05933 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.94 Å)

Structure validation