Structure of the translating mammalian ribosome-Sec61 complex

This is a large structure.
Replaces:  3J73

Summary for 3J7R

Related3J7O 3J7P 3J7Q
Integrates4W26 4W27 4W28
EMDB informationEMD-2644 EMD-2646 EMD-2649 EMD-2650
Descriptor28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (88 entities in total)
Functional Keywordsmammalian, sec61, translocation, translation, ribosome
Biological sourceSus scrofa (pig)
Cellular locationCell membrane  Q6QAP6
Cytoplasm  F2Z5U0 3J7R 3J7R 3J7R
Cell membrane ; Peripheral membrane protein  3J7R
Nucleus, nucleolus  
Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm  
Total number of polymer chains86
Total molecular weight3421661.33
Voorhees, R.M.,Fernandez, I.S.,Scheres, S.H.W.,Hegde, R.S. (deposition date: 2014-08-01, release date: 2014-09-03, Last modification date: 2015-04-15)
Primary citation
Voorhees, R.M.,Fernandez, I.S.,Scheres, S.H.,Hegde, R.S.
Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157:1632-1643, 2014
PubMed: 24930395 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2014.05.024
MImport into Mendeley
Experimental method

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone605.0%19.5%0.27MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j7r
no rotation
Molmil generated image of 3j7r
rotated about x axis by 90°
Molmil generated image of 3j7r
rotated about y axis by 90°
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