3J7Q

Structure of the idle mammalian ribosome-Sec61 complex

This is a large structure.
Replaces:  3J72

> Summary

Summary for 3J7Q

Related3J7O 3J7P 3J7R
Integrates4W24 4W25
EMDB informationEMD-2644 EMD-2646 EMD-2649 EMD-2650
Descriptor28S ribosomal RNA, 5S ribosomal RNA, 5.8S ribosomal RNA, ... (50 entities in total)
Functional Keywordsmammalian, sec61, translocation, translation, ribosome
Biological sourceSus scrofa (pig)
Cellular locationNucleus, nucleolus  Q29205
Ubiquitin: Cytoplasm . 60S ribosomal protein L40: Cytoplasm  P63053
Cytoplasm P83884
Total number of polymer chains48
Total molecular weight2172567.52
Authors
Voorhees, R.M.,Fernandez, I.S.,Scheres, S.H.W.,Hegde, R.S. (deposition date: 2014-08-01, release date: 2014-09-03, Last modification date: 2014-12-17)
Primary citation
Voorhees, R.M.,Fernandez, I.S.,Scheres, S.H.,Hegde, R.S.
Structure of the Mammalian ribosome-sec61 complex to 3.4 a resolution.
Cell(Cambridge,Mass.), 157:1632-1643, 2014
PubMed: 24930395 (PDB entries with the same primary citation)
DOI: 10.1016/j.cell.2014.05.024
MImport into Mendeley
Experimental method
ELECTRON MICROSCOPY (3.5 Å)
?

Structure validation

ClashscoreRamachandran outliersSidechain outliersRNA backbone564.2%20.9%0.28MetricValuePercentile RanksWorseBetterPercentile relative to all structuresPercentile relative to all EM structures

More Asymmetric unit images

Molmil generated image of 3j7q
no rotation
Molmil generated image of 3j7q
rotated about x axis by 90°
Molmil generated image of 3j7q
rotated about y axis by 90°

> Structural details

Entity

Chain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
528S ribosomal RNApolymer37221206103.01
Sus scrofa (pig)
75S ribosomal RNApolymer12038692.11
Sus scrofa (pig)
85.8S ribosomal RNApolymer15650144.01
Sus scrofa (pig)
ARibosomal protein uL2polymer25728089.11
UniProt (F2Z567)
Pfam (PF00181)
Pfam (PF03947)
Sus scrofa (pig)
BRibosomal protein uL3polymer39444759.81
Sus scrofa (pig)
CRibosomal protein uL4polymer36741635.51
Sus scrofa (pig)
DRibosomal protein uL18polymer29734418.01
UniProt (F1S530)
Pfam (PF14204)
Pfam (PF17144)
Sus scrofa (pig)
ERibosomal protein eL6polymer23627052.41
Sus scrofa (pig)
FRibosomal protein uL30polymer22526590.91
Sus scrofa (pig)
GRibosomal protein eL8polymer26630167.21
UniProt (I3LVI8)
Pfam (PF01248)
Sus scrofa (pig)
HRibosomal protein uL6polymer19221899.61
UniProt (I3LP78)
Pfam (PF00347)
Sus scrofa (pig)
IRibosomal protein uL16polymer21324465.91
Sus scrofa (pig)
JRibosomal protein uL5polymer17820248.51
UniProt (Q29205)
Pfam (PF00281)
Pfam (PF00673)
Sus scrofa (pig)
LRibosomal protein eL13polymer21124366.01
UniProt (I3LSD3)
Pfam (PF01294)
Sus scrofa (pig)
MRibosomal protein eL14polymer21323383.21
UniProt (A1XQU3)
Pfam (PF01929)
Sus scrofa (pig)
NRibosomal protein eL15polymer20424207.51
UniProt (I3LK33)
Pfam (PF00827)
Sus scrofa (pig)
ORibosomal protein uL13polymer20423765.71
UniProt (F1RI01)
Pfam (PF00572)
Sus scrofa (pig)
PRibosomal protein uL22polymer15317757.81
Sus scrofa (pig)
QRibosomal protein eL18polymer18821588.71
UniProt (I3L6F1)
Pfam (PF17135)
Sus scrofa (pig)
RRibosomal protein eL19polymer19623567.41
UniProt (F2Z546)
Pfam (PF01280)
Sus scrofa (pig)
SRibosomal protein eL20polymer22426103.61
UniProt (F1S935)
Pfam (PF01775)
Sus scrofa (pig)
TRibosomal protein eL21polymer16018610.11
UniProt (F1RTJ9)
Pfam (PF01157)
Sus scrofa (pig)
URibosomal protein eL22polymer12814785.11
UniProt (P67985)
Pfam (PF01776)
Sus scrofa (pig)
VRibosomal protein uL14polymer14014892.61
UniProt (P62831)
Pfam (PF00238)
Sus scrofa (pig)
WRibosomal protein eL24polymer15717825.31
Sus scrofa (pig)
XRibosomal protein uL23polymer15617740.41
UniProt (F2Z522)
Pfam (PF00276)
Pfam (PF03939)
Sus scrofa (pig)
YRibosomal protein uL24polymer14517303.51
UniProt (I3L7Y1)
Pfam (PF00467)
Pfam (PF16906)
Sus scrofa (pig)
ZRibosomal protein eL27polymer13615836.01
UniProt (A1XQU5)
Pfam (PF00467)
Pfam (PF01777)
Sus scrofa (pig)
aRibosomal protein uL15polymer14816631.71
UniProt (F1RGC0)
Pfam (PF00828)
Sus scrofa (pig)
bRibosomal protein eL29polymer16017546.01
UniProt (Q95281)
Pfam (PF01779)
Sus scrofa (pig)
cRibosomal protein eL30polymer11512805.21
UniProt (F2Z554)
Pfam (PF01248)
Sus scrofa (pig)
dRibosomal protein eL31polymer12514495.11
UniProt (P62901)
Pfam (PF01198)
Sus scrofa (pig)
eRibosomal protein eL32polymer13515899.11
UniProt (Q6QAT0)
Pfam (PF01655)
Sus scrofa (pig)
fRibosomal protein eL33polymer11012564.81
UniProt (F2Z5Q8)
Pfam (PF01247)
Sus scrofa (pig)
gRibosomal protein eL34polymer11713326.21
UniProt (F2Z5B9)
Pfam (PF01199)
Sus scrofa (pig)
hRibosomal protein uL29polymer12314591.81
UniProt (Q29361)
Pfam (PF00831)
Sus scrofa (pig)
iRibosomal protein eL36polymer10512291.01
UniProt (F2Z5K6)
Pfam (PF01158)
Sus scrofa (pig)
jRibosomal protein eL37polymer8610103.01
Sus scrofa (pig)
kRibosomal protein eL38polymer708239.01
UniProt (F2Z568)
Pfam (PF01781)
Sus scrofa (pig)
lRibosomal protein eL39polymer516426.81
UniProt (K7GP63)
Pfam (PF00832)
Sus scrofa (pig)
mRibosomal protein eL40polymer12814758.51
UniProt (P63053)
Pfam (PF00240)
Pfam (PF01020)
Sus scrofa (pig)
nRibosomal protein eL41polymer253473.51
Sus scrofa (pig)
oRibosomal protein eL42polymer10612477.11
UniProt (P83884)
Pfam (PF00935)
Sus scrofa (pig)
pRibosomal protein eL43polymer9110168.21
Sus scrofa (pig)
rRibosomal protein eL28polymer12514301.91
Sus scrofa (pig)
1Sec61 alpha subunitpolymer47652279.91
Sus scrofa (pig)
2Sec61 gamma subunitpolymer687752.41
UniProt (F2Z5D9)
Pfam (PF00584)
Sus scrofa (pig)
3Sec61 beta subunitpolymer363081.81
Sus scrofa (pig)
MAGNESIUM IONnon-polymer24.3130
ZINC IONnon-polymer65.43

Sequence viewer

Contents of the asymmetric unit

PolymersNumber of chains48
Total molecular weight2169211.7
Non-Polymers*Number of molecules133
Total molecular weight3355.8
All*Total molecular weight2172567.5
*Water molecules are not included.

> Experimental details

Refinement Statistics

Experimental method:ELECTRON MICROSCOPY (3.5 Å)

Cell axes1.0001.0001.000
Cell angles90.0090.0090.00
SpacegroupP 1
Resolution limits268.00 - 3.50
the highest resolution shell value3.591 - 3.500
R-factor0.2823
R-work0.28230
the highest resolution shell value0.406
RMSD bond length0.011
RMSD bond angle1.916

Data Collection Statistics

Resolution limits -
the highest resolution shell value -

Crystallization Conditions

crystal IDmethodpHpH rangetemperatureunit

Crystallization Reagents

IDcrystal IDsolution IDreagent nameconcentrationdetails
Crystallization Reagents in Literatures*
IDcrystal IDsolutionreagent nameconcentration (unit)details
Annotated Information is extracted from Literature Info*

> Functional details

?

Functional Information from GO Data

ChainGOidnamespacecontents
J0022625cellular_componentcytosolic large ribosomal subunit
J0005730cellular_componentnucleolus
J0005654cellular_componentnucleoplasm
J0019843molecular_functionrRNA binding
J0003735molecular_functionstructural constituent of ribosome
J0034504biological_processprotein localization to nucleus
J0000027biological_processribosomal large subunit assembly
J0006412biological_processtranslation
M0005840cellular_componentribosome
M0003735molecular_functionstructural constituent of ribosome
M0006412biological_processtranslation
U0022625cellular_componentcytosolic large ribosomal subunit
U0008201molecular_functionheparin binding
U0003723molecular_functionRNA binding
U0003735molecular_functionstructural constituent of ribosome
U0002181biological_processcytoplasmic translation
V0022625cellular_componentcytosolic large ribosomal subunit
V0070062cellular_componentextracellular exosome
V0031012cellular_componentextracellular matrix
V0005925cellular_componentfocal adhesion
V0016020cellular_componentmembrane
V0005730cellular_componentnucleolus
V0005654cellular_componentnucleoplasm
V0043234cellular_componentprotein complex
V0070180molecular_functionlarge ribosomal subunit rRNA binding
V0003735molecular_functionstructural constituent of ribosome
V0001223molecular_functiontranscription coactivator binding
V1990948molecular_functionubiquitin ligase inhibitor activity
V0031625molecular_functionubiquitin protein ligase binding
V0072717biological_processcellular response to actinomycin D
V0071157biological_processnegative regulation of cell cycle arrest
V2000059biological_processnegative regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process
V0000122biological_processnegative regulation of transcription from RNA polymerase II promoter
V0071158biological_processpositive regulation of cell cycle arrest
V0008284biological_processpositive regulation of cell proliferation
V1901798biological_processpositive regulation of signal transduction by p53 class mediator
V0045944biological_processpositive regulation of transcription from RNA polymerase II promoter
V0050821biological_processprotein stabilization
V0032986biological_processprotein-DNA complex disassembly
V0006412biological_processtranslation
Z0022625cellular_componentcytosolic large ribosomal subunit
Z0003735molecular_functionstructural constituent of ribosome
Z0006412biological_processtranslation
b0022625cellular_componentcytosolic large ribosomal subunit
b0016020cellular_componentmembrane
b0045296molecular_functioncadherin binding
b0003723molecular_functionRNA binding
b0003735molecular_functionstructural constituent of ribosome
b0002181biological_processcytoplasmic translation
d0005840cellular_componentribosome
d0003735molecular_functionstructural constituent of ribosome
d0006412biological_processtranslation
e0022625cellular_componentcytosolic large ribosomal subunit
e0016020cellular_componentmembrane
e0003723molecular_functionRNA binding
e0003735molecular_functionstructural constituent of ribosome
e0006412biological_processtranslation
h0022625cellular_componentcytosolic large ribosomal subunit
h0016020cellular_componentmembrane
h0003729molecular_functionmRNA binding
h0003735molecular_functionstructural constituent of ribosome
h0000463biological_processmaturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
h0006412biological_processtranslation
o0022625cellular_componentcytosolic large ribosomal subunit
o0005634cellular_componentnucleus
o0005886cellular_componentplasma membrane
o0003735molecular_functionstructural constituent of ribosome
o0006412biological_processtranslation
m0005829cellular_componentcytosol
m0005783cellular_componentendoplasmic reticulum
m0070062cellular_componentextracellular exosome
m0005615cellular_componentextracellular space
m0005765cellular_componentlysosomal membrane
m0043209cellular_componentmyelin sheath
m0005654cellular_componentnucleoplasm
m0005886cellular_componentplasma membrane
m0005840cellular_componentribosome
m0003735molecular_functionstructural constituent of ribosome
m0006412biological_processtranslation
f0005840cellular_componentribosome
f0003735molecular_functionstructural constituent of ribosome
f0006412biological_processtranslation
T0022625cellular_componentcytosolic large ribosomal subunit
T0016020cellular_componentmembrane
T0003723molecular_functionRNA binding
T0003735molecular_functionstructural constituent of ribosome
T0006412biological_processtranslation
X0022625cellular_componentcytosolic large ribosomal subunit
X0003735molecular_functionstructural constituent of ribosome
X0000027biological_processribosomal large subunit assembly
X0006412biological_processtranslation
N0022625cellular_componentcytosolic large ribosomal subunit
N0003735molecular_functionstructural constituent of ribosome
N0002181biological_processcytoplasmic translation
D0005840cellular_componentribosome
D0008097molecular_function5S rRNA binding
D0003735molecular_functionstructural constituent of ribosome
D0006412biological_processtranslation
i0022625cellular_componentcytosolic large ribosomal subunit
i0016020cellular_componentmembrane
i0005730cellular_componentnucleolus
i0003723molecular_functionRNA binding
i0003735molecular_functionstructural constituent of ribosome
i0002181biological_processcytoplasmic translation
A0022625cellular_componentcytosolic large ribosomal subunit
A0005925cellular_componentfocal adhesion
A0016020cellular_componentmembrane
A0003723molecular_functionRNA binding
A0003735molecular_functionstructural constituent of ribosome
A0002181biological_processcytoplasmic translation
20016021cellular_componentintegral component of membrane
20005622cellular_componentintracellular
20015450molecular_functionP-P-bond-hydrolysis-driven protein transmembrane transporter activity
20006605biological_processprotein targeting
l0005840cellular_componentribosome
l0003735molecular_functionstructural constituent of ribosome
l0006412biological_processtranslation
S0022625cellular_componentcytosolic large ribosomal subunit
S0016020cellular_componentmembrane
S0003723molecular_functionRNA binding
S0003735molecular_functionstructural constituent of ribosome
S0006412biological_processtranslation
L0022625cellular_componentcytosolic large ribosomal subunit
L0016020cellular_componentmembrane
L0005634cellular_componentnucleus
L0003723molecular_functionRNA binding
L0003735molecular_functionstructural constituent of ribosome
L0006412biological_processtranslation
G0030529cellular_componentintracellular ribonucleoprotein complex
G0042254biological_processribosome biogenesis
Y0022625cellular_componentcytosolic large ribosomal subunit
Y0070062cellular_componentextracellular exosome
Y0016020cellular_componentmembrane
Y0005730cellular_componentnucleolus
Y0005654cellular_componentnucleoplasm
Y0048027molecular_functionmRNA 5'-UTR binding
Y0003735molecular_functionstructural constituent of ribosome
Y0071480biological_processcellular response to gamma radiation
Y0006977biological_processDNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
Y1902164biological_processpositive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator
Y1902167biological_processpositive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator
Y0045727biological_processpositive regulation of translation
Y1904803biological_processregulation of translation involved in cellular response to UV
Y0042273biological_processribosomal large subunit biogenesis
Y0006364biological_processrRNA processing
Y0006412biological_processtranslation
O0015934cellular_componentlarge ribosomal subunit
O0003735molecular_functionstructural constituent of ribosome
O0006412biological_processtranslation
g0022625cellular_componentcytosolic large ribosomal subunit
g0070062cellular_componentextracellular exosome
g0005739cellular_componentmitochondrion
g0045296molecular_functioncadherin binding
g0003735molecular_functionstructural constituent of ribosome
g0006412biological_processtranslation
H0022625cellular_componentcytosolic large ribosomal subunit
H0031012cellular_componentextracellular matrix
H0005925cellular_componentfocal adhesion
H0016020cellular_componentmembrane
H0005634cellular_componentnucleus
H0003723molecular_functionRNA binding
H0019843molecular_functionrRNA binding
H0003735molecular_functionstructural constituent of ribosome
H0002181biological_processcytoplasmic translation
c0022625cellular_componentcytosolic large ribosomal subunit
c0070062cellular_componentextracellular exosome
c0031012cellular_componentextracellular matrix
c0005925cellular_componentfocal adhesion
c0016020cellular_componentmembrane
c0005634cellular_componentnucleus
c0003723molecular_functionRNA binding
c0003735molecular_functionstructural constituent of ribosome
c0006412biological_processtranslation
k0022625cellular_componentcytosolic large ribosomal subunit
k0033291cellular_componenteukaryotic 80S initiation complex
k0005925cellular_componentfocal adhesion
k0003735molecular_functionstructural constituent of ribosome
k0034463biological_process90S preribosome assembly
k0048318biological_processaxial mesoderm development
k0042474biological_processmiddle ear morphogenesis
k0001503biological_processossification
k0006417biological_processregulation of translation
k0007605biological_processsensory perception of sound
k0001501biological_processskeletal system development
k0006412biological_processtranslation
a0022625cellular_componentcytosolic large ribosomal subunit
a0003735molecular_functionstructural constituent of ribosome
a0006412biological_processtranslation
R0022625cellular_componentcytosolic large ribosomal subunit
R0003735molecular_functionstructural constituent of ribosome
R0006412biological_processtranslation
Q0005840cellular_componentribosome
Q0003735molecular_functionstructural constituent of ribosome
Q0006412biological_processtranslation
?

Functional Information from PDB Data

site_idNumber of ResiduesDetails
AC14BINDING SITE FOR RESIDUE MG 5 5101
ChainResidue
5G2584
gGLY55
gTHR70
gHIS73

AC22BINDING SITE FOR RESIDUE MG 5 5102
ChainResidue
5A39
5U3915

AC34BINDING SITE FOR RESIDUE MG 5 5103
ChainResidue
5U37
5A38
5G40
5C41

AC43BINDING SITE FOR RESIDUE MG 5 5104
ChainResidue
5U43
5A44
5U45

AC52BINDING SITE FOR RESIDUE MG 5 5105
ChainResidue
5A47
5G48

AC61BINDING SITE FOR RESIDUE MG 5 5106
ChainResidue
5A51

AC72BINDING SITE FOR RESIDUE MG 5 5107
ChainResidue
5G21
5A56

AC82BINDING SITE FOR RESIDUE MG 5 5108
ChainResidue
5A61
5G63

AC92BINDING SITE FOR RESIDUE MG 5 5109
ChainResidue
5A62
5U333

BC14BINDING SITE FOR RESIDUE MG 5 5110
ChainResidue
5A84
5G85
5G1383
5C1384

BC21BINDING SITE FOR RESIDUE MG 5 5112
ChainResidue
5A105

BC32BINDING SITE FOR RESIDUE MG 5 5113
ChainResidue
5C112
5G156

BC41BINDING SITE FOR RESIDUE MG 5 5114
ChainResidue
5G114

BC52BINDING SITE FOR RESIDUE MG 5 5115
ChainResidue
5A198
5G240

BC61BINDING SITE FOR RESIDUE MG 5 5116
ChainResidue
5A235

BC72BINDING SITE FOR RESIDUE MG 5 5117
ChainResidue
5U231
5A235

BC81BINDING SITE FOR RESIDUE MG 5 5118
ChainResidue
5C282

BC92BINDING SITE FOR RESIDUE MG 5 5119
ChainResidue
5G288
5A4178

CC11BINDING SITE FOR RESIDUE MG 5 5120
ChainResidue
5U291

CC22BINDING SITE FOR RESIDUE MG 5 5121
ChainResidue
5A47
5U291

CC32BINDING SITE FOR RESIDUE MG 5 5122
ChainResidue
5U316
5U4354

CC42BINDING SITE FOR RESIDUE MG 5 5124
ChainResidue
5C351
5G2343

CC53BINDING SITE FOR RESIDUE MG 5 5126
ChainResidue
5G356
5C358
CGLY98

CC63BINDING SITE FOR RESIDUE MG 5 5127
ChainResidue
5A355
5G356
5A359

CC71BINDING SITE FOR RESIDUE MG 5 5128
ChainResidue
5A2332

CC83BINDING SITE FOR RESIDUE MG 5 5129
ChainResidue
5A407
5G2330
5G2331

CC94BINDING SITE FOR RESIDUE MG 5 5130
ChainResidue
5A410
5G415
5U416
5G2331

DC13BINDING SITE FOR RESIDUE MG 5 5131
ChainResidue
5G415
5U416
5G417

DC25BINDING SITE FOR RESIDUE MG 5 5132
ChainResidue
5C422
5G423
5U424
8A9
8G10

DC33BINDING SITE FOR RESIDUE MG 5 5134
ChainResidue
5C1665
5A2279
5G2280

DC41BINDING SITE FOR RESIDUE MG 5 5135
ChainResidue
5A2282

DC52BINDING SITE FOR RESIDUE MG 5 5136
ChainResidue
5A2367
5U2828

DC63BINDING SITE FOR RESIDUE MG 5 5137
ChainResidue
5A2368
5A2370
5U2826

DC71BINDING SITE FOR RESIDUE MG 5 5138
ChainResidue
5C2393

DC81BINDING SITE FOR RESIDUE MG 5 5139
ChainResidue
5A2401

DC93BINDING SITE FOR RESIDUE MG 5 5140
ChainResidue
5C2410
5C2411
5A2428

EC12BINDING SITE FOR RESIDUE MG 5 5141
ChainResidue
5C2422
5A2423

EC21BINDING SITE FOR RESIDUE MG 5 5142
ChainResidue
5G2510

EC32BINDING SITE FOR RESIDUE MG 5 5143
ChainResidue
5G2514
5G2516

EC41BINDING SITE FOR RESIDUE MG 5 5144
ChainResidue
5G2677

EC53BINDING SITE FOR RESIDUE MG 5 5145
ChainResidue
5G2402
5A2783
5C2784

EC63BINDING SITE FOR RESIDUE MG 5 5146
ChainResidue
5A2789
5G2827
5U2828

EC71BINDING SITE FOR RESIDUE MG 5 5147
ChainResidue
5C2792

EC84BINDING SITE FOR RESIDUE MG 5 5148
ChainResidue
5A1599
5A1600
5G2793
5C2794

EC91BINDING SITE FOR RESIDUE MG 5 5149
ChainResidue
5A2845

FC11BINDING SITE FOR RESIDUE MG 5 5150
ChainResidue
5A2857

FC22BINDING SITE FOR RESIDUE MG 5 5151
ChainResidue
5A2879
5A3629

FC31BINDING SITE FOR RESIDUE MG 5 5152
ChainResidue
5C3632

FC42BINDING SITE FOR RESIDUE MG 5 5153
ChainResidue
5G3634
5C3636

FC53BINDING SITE FOR RESIDUE MG 5 5154
ChainResidue
5A3642
5U3644
5U3645

FC64BINDING SITE FOR RESIDUE MG 5 5155
ChainResidue
5C3701
5U3704
5G3705
5U3745

FC74BINDING SITE FOR RESIDUE MG 5 5156
ChainResidue
5G3689
5A3747
5A3748
5U3818

FC81BINDING SITE FOR RESIDUE MG 5 5158
ChainResidue
5U3778

FC91BINDING SITE FOR RESIDUE MG 5 5159
ChainResidue
5A3783

GC11BINDING SITE FOR RESIDUE MG 5 5160
ChainResidue
5A3817

GC22BINDING SITE FOR RESIDUE MG 5 5161
ChainResidue
5A2363
5U3853

GC36BINDING SITE FOR RESIDUE MG 5 5162
ChainResidue
5A1324
5C1325
5G3875
5A3876
5A3877
5G3879

GC43BINDING SITE FOR RESIDUE MG 5 5163
ChainResidue
5C1678
5G3913
5U3914

GC53BINDING SITE FOR RESIDUE MG 5 5164
ChainResidue
5U3912
5C4193
5U4194

GC64BINDING SITE FOR RESIDUE MG 5 5165
ChainResidue
5G40
5C41
5U3915
5G3916

GC71BINDING SITE FOR RESIDUE MG 5 5166
ChainResidue
5A3917

GC83BINDING SITE FOR RESIDUE MG 5 5168
ChainResidue
5U3920
5G4184
APRO206

GC92BINDING SITE FOR RESIDUE MG 5 5169
ChainResidue
5A3923
5C3924

HC12BINDING SITE FOR RESIDUE MG 5 5170
ChainResidue
5U35
5U4188

HC22BINDING SITE FOR RESIDUE MG 5 5171
ChainResidue
5G1734
5U1735

HC32BINDING SITE FOR RESIDUE MG 5 5172
ChainResidue
5A4214
5C4215

HC42BINDING SITE FOR RESIDUE MG 5 5173
ChainResidue
5G4235
5C4332

HC51BINDING SITE FOR RESIDUE MG 5 5174
ChainResidue
5A4239

HC62BINDING SITE FOR RESIDUE MG 5 5175
ChainResidue
5A4281
DTYR31

HC71BINDING SITE FOR RESIDUE MG 5 5177
ChainResidue
5A4385

HC83BINDING SITE FOR RESIDUE MG 5 5178
ChainResidue
5G1633
5G1641
5G4534

HC95BINDING SITE FOR RESIDUE MG 5 5179
ChainResidue
5A1632
5G1633
5A4535
AALA203
AASN205

IC11BINDING SITE FOR RESIDUE MG 5 5180
ChainResidue
5A4533

IC23BINDING SITE FOR RESIDUE MG 5 5181
ChainResidue
5U1656
5G4392
5G4448

IC35BINDING SITE FOR RESIDUE MG 5 5182
ChainResidue
5G4393
5A4394
5C4443
5C4444
5U4445

IC43BINDING SITE FOR RESIDUE MG 5 5183
ChainResidue
5G1321
5A4394
5U4445

IC51BINDING SITE FOR RESIDUE MG 5 5184
ChainResidue
5G4401

IC61BINDING SITE FOR RESIDUE MG 5 5185
ChainResidue
5C4417

IC71BINDING SITE FOR RESIDUE MG 5 5186
ChainResidue
5A1871

IC83BINDING SITE FOR RESIDUE MG 5 5187
ChainResidue
5A3901
5A3902
5G4451

IC92BINDING SITE FOR RESIDUE MG 5 5188
ChainResidue
5A3902
5G4451

JC12BINDING SITE FOR RESIDUE MG 5 5189
ChainResidue
5A4479
5A4480

JC22BINDING SITE FOR RESIDUE MG 5 5190
ChainResidue
5G2851
5U2852

JC34BINDING SITE FOR RESIDUE MG 5 5191
ChainResidue
5A2850
5G2851
5U2852
5A4496

JC42BINDING SITE FOR RESIDUE MG 5 5192
ChainResidue
5C3833
5U4497

JC53BINDING SITE FOR RESIDUE MG 5 5193
ChainResidue
5G4451
5G4522
5U4557

JC63BINDING SITE FOR RESIDUE MG 5 5194
ChainResidue
5C4519
5G4520
5U4521

JC71BINDING SITE FOR RESIDUE MG 5 5196
ChainResidue
5A4464

JC84BINDING SITE FOR RESIDUE MG 5 5197
ChainResidue
5G3899
5U4521
5G4522
5A4523

JC92BINDING SITE FOR RESIDUE MG 5 5198
ChainResidue
5G1592
5U4526

KC12BINDING SITE FOR RESIDUE MG 5 5199
ChainResidue
5G4528
5G4529

KC22BINDING SITE FOR RESIDUE MG 5 5200
ChainResidue
5G3815
5G4538

KC33BINDING SITE FOR RESIDUE MG 5 5201
ChainResidue
5U1591
5G1592
5U4556

KC41BINDING SITE FOR RESIDUE MG 5 5202
ChainResidue
5G1595

KC51BINDING SITE FOR RESIDUE MG 5 5204
ChainResidue
5U4682

KC61BINDING SITE FOR RESIDUE MG 5 5205
ChainResidue
5A4705

KC72BINDING SITE FOR RESIDUE MG 5 5207
ChainResidue
5G4650
5A4651

KC84BINDING SITE FOR RESIDUE MG 5 5208
ChainResidue
5G4751
5U4752
5U4946
5C4948

KC91BINDING SITE FOR RESIDUE MG 5 5209
ChainResidue
5G1895

LC12BINDING SITE FOR RESIDUE MG 5 5210
ChainResidue
5C1318
5U1656

LC21BINDING SITE FOR RESIDUE MG 5 5211
ChainResidue
5G1680

LC32BINDING SITE FOR RESIDUE MG 5 5212
ChainResidue
5C1318
5U1659

LC43BINDING SITE FOR RESIDUE MG 5 5213
ChainResidue
5C322
5G4355
5G4356

LC51BINDING SITE FOR RESIDUE MG 5 5214
ChainResidue
5U416

LC63BINDING SITE FOR RESIDUE MG 5 5215
ChainResidue
5U354
5A378
5MG5216

LC75BINDING SITE FOR RESIDUE MG 5 5216
ChainResidue
5A353
5U354
5A378
5G379
5MG5215

LC82BINDING SITE FOR RESIDUE MG 5 5217
ChainResidue
5U380
5G415

LC92BINDING SITE FOR RESIDUE MG 5 5218
ChainResidue
5G1335
5C2346

MC12BINDING SITE FOR RESIDUE MG 5 5219
ChainResidue
5A4665
BLYS373

MC21BINDING SITE FOR RESIDUE MG 7 201
ChainResidue
7A42

MC33BINDING SITE FOR RESIDUE MG 7 202
ChainResidue
7U53
7A54
7A55

MC43BINDING SITE FOR RESIDUE MG 7 203
ChainResidue
7U53
7A55
7G56

MC51BINDING SITE FOR RESIDUE MG 7 204
ChainResidue
7G65

MC62BINDING SITE FOR RESIDUE MG 7 205
ChainResidue
5G1895
7A83

MC71BINDING SITE FOR RESIDUE MG 8 202
ChainResidue
8U14

MC81BINDING SITE FOR RESIDUE MG 8 203
ChainResidue
8A20

MC91BINDING SITE FOR RESIDUE MG 8 204
ChainResidue
8G151

NC11BINDING SITE FOR RESIDUE MG P 201
ChainResidue
PTYR130

NC21BINDING SITE FOR RESIDUE MG V 201
ChainResidue
VASN50

NC34BINDING SITE FOR RESIDUE ZN j 101
ChainResidue
jCYS19
jCYS22
jCYS34
jCYS37

NC44BINDING SITE FOR RESIDUE ZN m 201
ChainResidue
mCYS96
mCYS99
mCYS110
mCYS115

NC55BINDING SITE FOR RESIDUE ZN o 201
ChainResidue
oCYS12
oCYS15
oCYS72
oCYS77
oSER79

?

Functional Information from PDB atom coordinates for the "HETATM" binding sites

site_idNumber of ResiduesDetails
?

Functional Information from PROSITE/UniProt

site_idNumber of ResiduesDetails
?

Functional Information from SwissProt/UniProt

site_idNumber of ResiduesDetails
SWS_FT_FI12Activating enzyme.
ChainResidueDetails
mNA*
mNA*

?

Catalytic Information from CSA

site_idNumber of ResiduesDetails

> Sequence Neighbor

Sequence navigator - 3j7q: Chain 5
Sequence navigator - 3j7q: Chain 7
Sequence navigator - 3j7q: Chain 8
Sequence navigator - 3j7q: Chain A
Sequence navigator - 3j7q: Chain B
Sequence navigator - 3j7q: Chain C
Sequence navigator - 3j7q: Chain D
Sequence navigator - 3j7q: Chain E
Sequence navigator - 3j7q: Chain F
Sequence navigator - 3j7q: Chain G
Sequence navigator - 3j7q: Chain H
Sequence navigator - 3j7q: Chain I
Sequence navigator - 3j7q: Chain J
Sequence navigator - 3j7q: Chain L
Sequence navigator - 3j7q: Chain M
Sequence navigator - 3j7q: Chain N
Sequence navigator - 3j7q: Chain O
Sequence navigator - 3j7q: Chain P
Sequence navigator - 3j7q: Chain Q
Sequence navigator - 3j7q: Chain R
Sequence navigator - 3j7q: Chain S
Sequence navigator - 3j7q: Chain T
Sequence navigator - 3j7q: Chain U
Sequence navigator - 3j7q: Chain V
Sequence navigator - 3j7q: Chain W
Sequence navigator - 3j7q: Chain X
Sequence navigator - 3j7q: Chain Y
Sequence navigator - 3j7q: Chain Z
Sequence navigator - 3j7q: Chain a
Sequence navigator - 3j7q: Chain b
Sequence navigator - 3j7q: Chain c
Sequence navigator - 3j7q: Chain d
Sequence navigator - 3j7q: Chain e
Sequence navigator - 3j7q: Chain f
Sequence navigator - 3j7q: Chain g
Sequence navigator - 3j7q: Chain h
Sequence navigator - 3j7q: Chain i
Sequence navigator - 3j7q: Chain j
Sequence navigator - 3j7q: Chain k
Sequence navigator - 3j7q: Chain l
Sequence navigator - 3j7q: Chain m
Sequence navigator - 3j7q: Chain n
Sequence navigator - 3j7q: Chain o
Sequence navigator - 3j7q: Chain p
Sequence navigator - 3j7q: Chain r
Sequence navigator - 3j7q: Chain 1
Sequence navigator - 3j7q: Chain 2
Sequence navigator - 3j7q: Chain 3

> Downloads

PDBj@FacebookPDBj@TwitterwwPDBwwPDB FoundationEM DataBank

Copyright © 2013-2017 Protein Data Bank Japan