3H69
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![BU of 3h69 by Molmil](/molmil-images/mine/3h69) | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms complexed with endothall | Descriptor: | (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, Serine/threonine-protein phosphatase 5, ZINC ION | Authors: | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | Deposit date: | 2009-04-23 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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3H68
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![BU of 3h68 by Molmil](/molmil-images/mine/3h68) | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form) | Descriptor: | (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, Serine/threonine-protein phosphatase 5, ZINC ION | Authors: | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | Deposit date: | 2009-04-23 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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3HVQ
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![BU of 3hvq by Molmil](/molmil-images/mine/3hvq) | Crystal structure of a complex between Protein Phosphatase 1 alpha (PP1) and the PP1 binding and PDZ domains of Neurabin | Descriptor: | GLYCEROL, MANGANESE (II) ION, Neurabin-1, ... | Authors: | Critton, D.A, Ragusa, M.J, Page, R, Peti, W. | Deposit date: | 2009-06-16 | Release date: | 2010-03-23 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Spinophilin directs protein phosphatase 1 specificity by blocking substrate binding sites. Nat.Struct.Mol.Biol., 17, 2010
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3FGA
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![BU of 3fga by Molmil](/molmil-images/mine/3fga) | Structural Basis of PP2A and Sgo interaction | Descriptor: | MANGANESE (II) ION, MICROCYSTIN-LR, Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit gamma isoform, ... | Authors: | Xu, Z, Xu, W. | Deposit date: | 2008-12-05 | Release date: | 2009-09-22 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure and function of the PP2A-shugoshin interaction Mol.Cell, 35, 2009
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3H60
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![BU of 3h60 by Molmil](/molmil-images/mine/3h60) | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Mn2+ atoms | Descriptor: | MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | Authors: | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | Deposit date: | 2009-04-23 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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3ICF
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![BU of 3icf by Molmil](/molmil-images/mine/3icf) | Structure of Protein serine/threonine phosphatase from Saccharomyces cerevisiae with similarity to human phosphatase PP5 | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, FE (III) ION, ... | Authors: | Singer, A.U, Xu, X, Chang, C, Cui, H, Kagan, O, Edwards, A.M, Joachimiak, A, Yakunin, A.F, Savchenko, A, Midwest Center for Structural Genomics (MCSG) | Deposit date: | 2009-07-17 | Release date: | 2009-08-25 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of Protein serine/threonine phosphatase from Saccharomyces cerevisiae with similarity to human phosphatase PP5 To be Published
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3H64
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![BU of 3h64 by Molmil](/molmil-images/mine/3h64) | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Mn2+ atoms complexed with endothall | Descriptor: | (1R,2S,3R,4S)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, MANGANESE (II) ION, Serine/threonine-protein phosphatase 5 | Authors: | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | Deposit date: | 2009-04-23 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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3H66
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![BU of 3h66 by Molmil](/molmil-images/mine/3h66) | Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c) with two Zn2+ atoms | Descriptor: | Serine/threonine-protein phosphatase 5, ZINC ION | Authors: | Bertini, I, Calderone, V, Fragai, M, Luchinat, C, Talluri, E. | Deposit date: | 2009-04-23 | Release date: | 2009-09-29 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.59 Å) | Cite: | Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52, 2009
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3IVD
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![BU of 3ivd by Molmil](/molmil-images/mine/3ivd) | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine | Descriptor: | CHLORIDE ION, FE (III) ION, MANGANESE (II) ION, ... | Authors: | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-08-31 | Release date: | 2009-09-29 | Last modified: | 2021-02-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Uridine To be Published
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3IVE
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![BU of 3ive by Molmil](/molmil-images/mine/3ive) | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine | Descriptor: | 4-AMINO-1-BETA-D-RIBOFURANOSYL-2(1H)-PYRIMIDINONE, CHLORIDE ION, FE (III) ION, ... | Authors: | Ramagopal, U.A, Toro, R, Burley, S.K, Almo, S.C, New York SGX Research Center for Structural Genomics (NYSGXRC) | Deposit date: | 2009-08-31 | Release date: | 2009-09-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Putative 5'-Nucleotidase (c4898) from Escherichia Coli in complex with Cytidine To be Published
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7SQC
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![BU of 7sqc by Molmil](/molmil-images/mine/7sqc) | Ciliary C1 central pair apparatus isolated from Chlamydomonas reinhardtii | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, CPC1, Calmodulin, ... | Authors: | Gui, M, Wang, X, Dutcher, S.K, Brown, A, Zhang, R. | Deposit date: | 2021-11-05 | Release date: | 2022-04-13 | Last modified: | 2024-06-05 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Ciliary central apparatus structure reveals mechanisms of microtubule patterning. Nat.Struct.Mol.Biol., 29, 2022
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8GAE
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![BU of 8gae by Molmil](/molmil-images/mine/8gae) | Hsp90 provides platform for CRaf dephosphorylation by PP5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | Authors: | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | Deposit date: | 2023-02-22 | Release date: | 2023-04-26 | Last modified: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
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8GFT
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![BU of 8gft by Molmil](/molmil-images/mine/8gft) | Hsp90 provides platform for CRaf dephosphorylation by PP5 | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Heat shock protein HSP 90-beta, ... | Authors: | Jaime-Garza, M, Nowotny, C.A, Coutandin, D, Wang, F, Tabios, M, Agard, D.A. | Deposit date: | 2023-03-08 | Release date: | 2023-05-03 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Hsp90 provides a platform for kinase dephosphorylation by PP5. Nat Commun, 14, 2023
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4V0U
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![BU of 4v0u by Molmil](/molmil-images/mine/4v0u) | The crystal structure of ternary PP1G-PPP1R15B and G-actin complex | Descriptor: | ACTIN, ALPHA SKELETAL MUSCLE, ADENOSINE-5'-TRIPHOSPHATE, ... | Authors: | Chen, R, Yan, Y, Casado, A.C, Ron, D, Read, R.J. | Deposit date: | 2014-09-18 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (7.88 Å) | Cite: | G-actin provides substrate-specificity to eukaryotic initiation factor 2 alpha holophosphatases. Elife, 4, 2015
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7N6G
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![BU of 7n6g by Molmil](/molmil-images/mine/7n6g) | C1 of central pair | Descriptor: | CPC1, Calmodulin, DPY30, ... | Authors: | Han, L, Zhang, K. | Deposit date: | 2021-06-08 | Release date: | 2022-05-18 | Last modified: | 2022-06-01 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of an active central apparatus. Nat.Struct.Mol.Biol., 29, 2022
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7NZM
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![BU of 7nzm by Molmil](/molmil-images/mine/7nzm) | Cryo-EM structure of pre-dephosphorylation complex of phosphorylated eIF2alpha with trapped holophosphatase (PP1A_D64A/PPP1R15A/G-actin/DNase I) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | Authors: | Yan, Y, Hardwick, S, Ron, D. | Deposit date: | 2021-03-24 | Release date: | 2021-09-29 | Last modified: | 2021-10-20 | Method: | ELECTRON MICROSCOPY (3.96 Å) | Cite: | Higher-order phosphatase-substrate contacts terminate the integrated stress response. Nat.Struct.Mol.Biol., 28, 2021
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7YCX
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![BU of 7ycx by Molmil](/molmil-images/mine/7ycx) | The structure of INTAC-PEC complex | Descriptor: | DNA-directed RNA polymerase II subunit E, DNA-directed RNA polymerase II subunit F, DNA-directed RNA polymerase II subunit RPB1,DNA-directed RNA polymerase II subunit RPB1, ... | Authors: | Zheng, H, Jin, Q, Wang, X, Qi, Y, Liu, W, Ren, Y, Zhao, D, Chen, F.X, Cheng, J, Chen, X, Xu, Y. | Deposit date: | 2022-07-02 | Release date: | 2023-03-15 | Last modified: | 2023-09-27 | Method: | ELECTRON MICROSCOPY (4.18 Å) | Cite: | Structural basis of INTAC-regulated transcription. Protein Cell, 14, 2023
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7TVF
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![BU of 7tvf by Molmil](/molmil-images/mine/7tvf) | |
7TXH
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![BU of 7txh by Molmil](/molmil-images/mine/7txh) | Human MRas Q71R in complex with human Shoc2 LRR domain M173I and human PP1Ca | Descriptor: | GLYCEROL, Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, ... | Authors: | Hauseman, Z.J, Viscomi, J, Dhembi, A, Clark, K, King, D.A, Fodor, M. | Deposit date: | 2022-02-09 | Release date: | 2022-06-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Structure of the MRAS-SHOC2-PP1C phosphatase complex. Nature, 609, 2022
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7UPI
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![BU of 7upi by Molmil](/molmil-images/mine/7upi) | Cryo-EM structure of SHOC2-PP1c-MRAS holophosphatase complex | Descriptor: | CHLORIDE ION, GUANOSINE-5'-TRIPHOSPHATE, Leucine-rich repeat protein SHOC-2, ... | Authors: | Fuller, J.R, Hajian, B, Lemke, C, Kwon, J, Bian, Y, Aguirre, A. | Deposit date: | 2022-04-15 | Release date: | 2022-05-04 | Last modified: | 2024-06-12 | Method: | ELECTRON MICROSCOPY (2.89 Å) | Cite: | Structure-function analysis of the SHOC2-MRAS-PP1C holophosphatase complex. Nature, 609, 2022
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6GHM
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![BU of 6ghm by Molmil](/molmil-images/mine/6ghm) | Structure of PP1 alpha phosphatase bound to ASPP2 | Descriptor: | 1,2-ETHANEDIOL, 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Apoptosis-stimulating of p53 protein 2, ... | Authors: | Mouilleron, S, Bertran, T.M, Tapon, N, Zhou, Y. | Deposit date: | 2018-05-08 | Release date: | 2019-02-27 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.15 Å) | Cite: | ASPP proteins discriminate between PP1 catalytic subunits through their SH3 domain and the PP1 C-tail. Nat Commun, 10, 2019
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7ZR5
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![BU of 7zr5 by Molmil](/molmil-images/mine/7zr5) | |
7ZR6
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![BU of 7zr6 by Molmil](/molmil-images/mine/7zr6) | |
8B5R
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![BU of 8b5r by Molmil](/molmil-images/mine/8b5r) | p97-p37-SPI substrate complex | Descriptor: | I3 sequence being threaded through the p97 channel, Protein phosphatase 1 regulatory subunit 7, Serine/threonine-protein phosphatase PP1-gamma catalytic subunit, ... | Authors: | van den Boom, J, Marini, G, Meyer, H, Saibil, H. | Deposit date: | 2022-09-24 | Release date: | 2023-06-07 | Last modified: | 2024-07-24 | Method: | ELECTRON MICROSCOPY (6.1 Å) | Cite: | Structural basis of ubiquitin-independent PP1 complex disassembly by p97. Embo J., 42, 2023
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7SD0
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![BU of 7sd0 by Molmil](/molmil-images/mine/7sd0) | Cryo-EM structure of the SHOC2:PP1C:MRAS complex | Descriptor: | Leucine-rich repeat protein SHOC-2, MAGNESIUM ION, MANGANESE (II) ION, ... | Authors: | Liau, N.P.D, Johnson, M.C, Hymowitz, S.G, Sudhamsu, J. | Deposit date: | 2021-09-29 | Release date: | 2022-04-20 | Last modified: | 2023-11-29 | Method: | ELECTRON MICROSCOPY (2.95 Å) | Cite: | Structural basis for SHOC2 modulation of RAS signalling. Nature, 609, 2022
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