3H68
Catalytic domain of human Serine/Threonine Phosphatase 5 (PP5c)with two Zn2+ atoms originally soaked with cantharidin (which is present in the structure in the hydrolyzed form)
Summary for 3H68
| Entry DOI | 10.2210/pdb3h68/pdb |
| Related | 3H60 3H61 3H62 3H63 3H64 3H66 3H67 3H69 |
| Descriptor | Serine/threonine-protein phosphatase 5, ZINC ION, (1R,2S,3R,4S)-2,3-dimethyl-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid, ... (4 entities in total) |
| Functional Keywords | metalloenzyme, phosphatase, inhibitors, drug design, cytoplasm, hydrolase, iron, manganese, metal-binding, nucleus, protein phosphatase, tpr repeat |
| Biological source | Homo sapiens (human) |
| Cellular location | Nucleus: P53041 |
| Total number of polymer chains | 2 |
| Total formula weight | 72591.66 |
| Authors | Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. (deposition date: 2009-04-23, release date: 2009-09-29, Last modification date: 2023-11-01) |
| Primary citation | Bertini, I.,Calderone, V.,Fragai, M.,Luchinat, C.,Talluri, E. Structural basis of serine/threonine phosphatase inhibition by the archetypal small molecules cantharidin and norcantharidin J.Med.Chem., 52:4838-4843, 2009 Cited by PubMed: 19601647DOI: 10.1021/jm900610k PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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