6V7K
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4WPB
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![BU of 4wpb by Molmil](/molmil-images/mine/4wpb) | Vascular endothelial growth factor in complex with alpha/beta-VEGF-1 | Descriptor: | Vascular endothelial growth factor A, alpha/beta-VEGF-1 | Authors: | Kreitler, D.F, Checco, J.W, Gellman, S.H, Forest, K.T. | Deposit date: | 2014-10-17 | Release date: | 2015-04-15 | Last modified: | 2024-07-10 | Method: | X-RAY DIFFRACTION (3.11 Å) | Cite: | Targeting diverse protein-protein interaction interfaces with alpha / beta-peptides derived from the Z-domain scaffold. Proc.Natl.Acad.Sci.USA, 112, 2015
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4KZN
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![BU of 4kzn by Molmil](/molmil-images/mine/4kzn) | crystal structure of human VEGF-A receptor binding domain | Descriptor: | SULFATE ION, TRIETHYLENE GLYCOL, Vascular endothelial growth factor A, ... | Authors: | Liaw, Y.C. | Deposit date: | 2013-05-30 | Release date: | 2014-06-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.7114 Å) | Cite: | Structural Basis for the Bivalent Glycosylated Human VEGF-A121 and VEGF-A165 in recruiment of Receptor and Co-receptor to be published
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3BDY
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![BU of 3bdy by Molmil](/molmil-images/mine/3bdy) | Dual specific bH1 Fab in complex with VEGF | Descriptor: | Fab Fragment -Heavy Chain, Fab Fragment -Light Chain, GLYCEROL, ... | Authors: | Bostrom, J.M, Wiesmann, C, Appleton, B.A. | Deposit date: | 2007-11-15 | Release date: | 2008-11-18 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Variants of the antibody herceptin that interact with HER2 and VEGF at the antigen binding site Science, 323, 2009
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4ZFF
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![BU of 4zff by Molmil](/molmil-images/mine/4zff) | Dual-acting Fab 5A12 in complex with VEGF | Descriptor: | Fragment antigen binding (Fab) 5A12 Heavy chain, Fragment antigen binding (Fab) 5A12 Light chain, SULFATE ION, ... | Authors: | Harris, S.F, Wu, P. | Deposit date: | 2015-04-21 | Release date: | 2015-07-01 | Last modified: | 2015-09-16 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Deep Sequencing-guided Design of a High Affinity Dual Specificity Antibody to Target Two Angiogenic Factors in Neovascular Age-related Macular Degeneration. J.Biol.Chem., 290, 2015
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2C7W
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![BU of 2c7w by Molmil](/molmil-images/mine/2c7w) | Crystal Structure of human vascular endothelial growth factor-B: Identification of amino acids important for angiogeninc activity | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, VASCULAR ENDOTHELIAL GROWTH FACTOR B PRECURSOR | Authors: | Iyer, S, Scotney, P.D, Nash, A.D, Acharya, K.R. | Deposit date: | 2005-11-29 | Release date: | 2007-01-30 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.48 Å) | Cite: | Crystal Structure of Human Vascular Endothelial Growth Factor-B: Identification of Amino Acids Important for Receptor Binding J.Mol.Biol., 359, 2006
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6T9D
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![BU of 6t9d by Molmil](/molmil-images/mine/6t9d) | Crystal structure of a bispecific DutaFab in complex with human VEGF121 | Descriptor: | VP mat DutaFab VH chain, VP mat DutaFab VL chain, Vascular endothelial growth factor A | Authors: | Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H. | Deposit date: | 2019-10-28 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.905 Å) | Cite: | DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously. Nat Commun, 12, 2021
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6D3O
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6T9E
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![BU of 6t9e by Molmil](/molmil-images/mine/6t9e) | Crystal structure of a bispecific DutaFab in complex with human PDGF | Descriptor: | DutaFab mat VH chain, DutaFab mat VL chain, Platelet-derived growth factor subunit B | Authors: | Kimbung, R, Logan, D.T, Beckmann, R, Jensen, K, Speck, J, Fenn, S, Kettenberger, H. | Deposit date: | 2019-10-28 | Release date: | 2020-12-16 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.989 Å) | Cite: | DutaFabs are engineered therapeutic Fab fragments that can bind two targets simultaneously. Nat Commun, 12, 2021
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1FZV
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![BU of 1fzv by Molmil](/molmil-images/mine/1fzv) | THE CRYSTAL STRUCTURE OF HUMAN PLACENTA GROWTH FACTOR-1 (PLGF-1), AN ANGIOGENIC PROTEIN AT 2.0A RESOLUTION | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, PLACENTA GROWTH FACTOR | Authors: | Iyer, S, Leonidas, D.D, Swaminathan, G.J, Maglione, D, Battisti, M, Tucci, M, Persico, M.G, Acharya, K.R. | Deposit date: | 2000-10-04 | Release date: | 2001-05-09 | Last modified: | 2022-12-21 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | The crystal structure of human placenta growth factor-1 (PlGF-1), an angiogenic protein, at 2.0 A resolution. J.Biol.Chem., 276, 2001
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4QCI
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![BU of 4qci by Molmil](/molmil-images/mine/4qci) | PDGF-B blocking antibody bound to PDGF-BB | Descriptor: | Platelet-derived growth factor subunit B, anti-PDGF-BB antibody - Light Chain, anti-PDGF-BB antibody - Heavy chain | Authors: | Kuai, J, Mosyak, L, Tam, M, LaVallie, E, Pullen, N, Carven, G. | Deposit date: | 2014-05-12 | Release date: | 2015-03-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Characterization of Binding Mode of Action of a Blocking Anti-Platelet-Derived Growth Factor (PDGF)-B Monoclonal Antibody, MOR8457, Reveals Conformational Flexibility and Avidity Needed for PDGF-BB To Bind PDGF Receptor-beta. Biochemistry, 54, 2015
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1KAT
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![BU of 1kat by Molmil](/molmil-images/mine/1kat) | Solution Structure of a Phage-Derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor | Descriptor: | Phage-Derived Peptide Antagonist, Vascular Endothelial Growth Factor | Authors: | Pan, B, Li, B, Russell, S.J, Tom, J.Y.K, Cochran, A.G, Fairbrother, W.J. | Deposit date: | 2001-11-02 | Release date: | 2002-11-02 | Last modified: | 2022-02-23 | Method: | SOLUTION NMR | Cite: | Solution Structure of a Phage-derived Peptide Antagonist in Complex with Vascular Endothelial Growth Factor J.Mol.Biol., 316, 2002
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1MJV
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![BU of 1mjv by Molmil](/molmil-images/mine/1mjv) | DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C51A and C60A) | Descriptor: | Vascular Endothelial Growth Factor A | Authors: | Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H. | Deposit date: | 2002-08-28 | Release date: | 2002-12-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor J.Biol.Chem., 277, 2002
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1BJ1
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![BU of 1bj1 by Molmil](/molmil-images/mine/1bj1) | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH A NEUTRALIZING ANTIBODY | Descriptor: | Fab fragment, heavy chain, light chain, ... | Authors: | Muller, Y.A, Christinger, H.W, De Vos, A.M. | Deposit date: | 1998-06-30 | Release date: | 1999-01-13 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | VEGF and the Fab fragment of a humanized neutralizing antibody: crystal structure of the complex at 2.4 A resolution and mutational analysis of the interface. Structure, 6, 1998
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1MKK
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![BU of 1mkk by Molmil](/molmil-images/mine/1mkk) | Disulfide deficient mutant of vascular endothelial growth factor A (C61A and C104A) | Descriptor: | Vascular Endothelial Growth Factor A | Authors: | Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H. | Deposit date: | 2002-08-29 | Release date: | 2002-12-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (1.32 Å) | Cite: | The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor J.Biol.Chem., 277, 2002
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2QR0
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![BU of 2qr0 by Molmil](/molmil-images/mine/2qr0) | Structure of VEGF complexed to a Fab containing TYR and SER in the CDRs | Descriptor: | Fab-Fragment Heavy Chain, Fab-Fragment Light Chain, Vascular endothelial growth factor A | Authors: | Wiesmann, C. | Deposit date: | 2007-07-27 | Release date: | 2007-08-14 | Last modified: | 2017-10-25 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | High-throughput generation of synthetic antibodies from highly functional minimalist phage-displayed libraries J.Mol.Biol., 373, 2007
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2FJH
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![BU of 2fjh by Molmil](/molmil-images/mine/2fjh) | Structure of the B20-4 Fab, a phage derived Fab fragment, in complex with VEGF | Descriptor: | Fab fragment heavy chain, Fab fragment light chain, Vascular endothelial growth factor A | Authors: | Wiesmann, C. | Deposit date: | 2006-01-02 | Release date: | 2006-02-07 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure-function studies of two synthetic anti-vascular endothelial growth factor Fabs and comparison with the Avastin Fab. J.Biol.Chem., 281, 2006
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2FJG
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2GNN
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![BU of 2gnn by Molmil](/molmil-images/mine/2gnn) | Crystal Structure of the Orf Virus NZ2 Variant of VEGF-E | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, BENZAMIDINE, ... | Authors: | Prota, A.E, Pieren, M, Wagner, A, Kostrewa, D, Winkler, F.K, Ballmer-Hofer, K. | Deposit date: | 2006-04-10 | Release date: | 2006-05-09 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Orf virus NZ2 variant of vascular endothelial growth factor-E. Implications for receptor specificity. J.Biol.Chem., 281, 2006
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2VPF
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1MKG
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![BU of 1mkg by Molmil](/molmil-images/mine/1mkg) | DISULFIDE DEFICIENT MUTANT OF VASCULAR ENDOTHELIAL GROWTH FACTOR A (C57A and C102A) | Descriptor: | Vascular Endothelial Growth Factor A | Authors: | Muller, Y.A, Heiring, C, Misselwitz, R, Welfle, K, Welfle, H. | Deposit date: | 2002-08-29 | Release date: | 2002-12-11 | Last modified: | 2021-10-27 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | The cystine knot promotes folding and not thermodynamic stability in vascular endothelial growth factor J.Biol.Chem., 277, 2002
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2VWE
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![BU of 2vwe by Molmil](/molmil-images/mine/2vwe) | Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment | Descriptor: | ANTI-VEGF-B MONOCLONAL ANTIBODY, VASCULAR ENDOTHELIAL GROWTH FACTOR B | Authors: | Leonard, P, Scotney, P.D, Jabeen, T, Iyer, S, Fabri, L.J, Nash, A.D, Acharya, K.R. | Deposit date: | 2008-06-23 | Release date: | 2008-11-04 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (3.4 Å) | Cite: | Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment. J.Mol.Biol., 384, 2008
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1CZ8
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![BU of 1cz8 by Molmil](/molmil-images/mine/1cz8) | VASCULAR ENDOTHELIAL GROWTH FACTOR IN COMPLEX WITH AN AFFINITY MATURED ANTIBODY | Descriptor: | HEAVY CHAIN OF NEUTRALIZING ANTIBODY, LIGHT CHAIN OF NEUTRALIZING ANTIBODY, SULFATE ION, ... | Authors: | Chen, Y, Wiesmann, C, Fuh, G, Li, B, Christinger, H.W, McKay, P, de Vos, A.M, Lowman, H.B. | Deposit date: | 1999-09-01 | Release date: | 2000-03-20 | Last modified: | 2017-04-05 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Selection and analysis of an optimized anti-VEGF antibody: crystal structure of an affinity-matured Fab in complex with antigen. J.Mol.Biol., 293, 1999
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1WQ8
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![BU of 1wq8 by Molmil](/molmil-images/mine/1wq8) | Crystal structure of Vammin, a VEGF-F from a snake venom | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Vascular endothelial growth factor toxin | Authors: | Suto, K, Yamazaki, Y, Morita, T, Mizuno, H. | Deposit date: | 2004-09-23 | Release date: | 2004-12-07 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Crystal structures of novel vascular endothelial growth factors (VEGF) from snake venoms: insight into selective VEGF binding to kinase insert domain-containing receptor but not to fms-like tyrosine kinase-1. J.Biol.Chem., 280, 2005
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3P9W
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