2VWE

Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralizing Antibody Fab Fragment

Summary for 2VWE

• Entry DOI: 10.2210/pdb2vwe/pdb
• Related: 2C7W
• Descriptor: VASCULAR ENDOTHELIAL GROWTH FACTOR B, ANTI-VEGF-B MONOCLONAL ANTIBODY (3 entities in total)
• Functional Keywords: immune system, glycoprotein, cysteine-knot, growth factor, vegf-b, mitogen, secreted, angiogenesis, neutralizing antibody, heparin-binding
• Biological source: HOMO SAPIENS (HUMAN); More
• Cellular location: Secreted: P49765
• Total number of polymer chains: 6
• Total formula weight: 132355.25

Authors

Leonard, P.,Scotney, P.D.,Jabeen, T.,Iyer, S.,Fabri, L.J.,Nash, A.D.,Acharya, K.R. (deposition date: 2008-06-23, release date: 2008-11-04, Last modification date: 2023-12-13)

• Primary citation: Leonard, P.,Scotney, P.D.,Jabeen, T.,Iyer, S.,Fabri, L.J.,Nash, A.D.,Acharya, K.R.; Crystal Structure of Vascular Endothelial Growth Factor-B in Complex with a Neutralising Antibody Fab Fragment.; J.Mol.Biol., 384:1203-, 2008; PubMed: 18930733; DOI: 10.1016/J.JMB.2008.09.076

Experimental method

X-RAY DIFFRACTION (3.4 Å)