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8DZS
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GR89,696 bound Kappa Opioid Receptor in complex with Gz
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(z) subunit alpha, ...
著者Fay, J.F, Che, T.
登録日2022-08-08
公開日2023-05-03
最終更新日2023-05-24
実験手法ELECTRON MICROSCOPY (2.65 Å)
主引用文献Ligand and G-protein selectivity in the kappa-opioid receptor.
Nature, 617, 2023
6S0Q
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Structure of the A2A adenosine receptor determined at SwissFEL using native-SAD at 4.57 keV from 50,000 diffraction patterns
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-{2-[(7-amino-2-furan-2-yl[1,2,4]triazolo[1,5-a][1,3,5]triazin-5-yl)amino]ethyl}phenol, ...
著者Nass, K, Cheng, R, Vera, L, Mozzanica, A, Redford, S, Ozerov, D, Basu, S, James, D, Knopp, G, Cirelli, C, Martiel, I, Casadei, C, Weinert, T, Nogly, P, Skopintsev, P, Usov, I, Leonarski, F, Geng, T, Rappas, M, Dore, A.S, Cooke, R, Nasrollahi Shirazi, S, Dworkowski, F, Sharpe, M, Olieric, N, Steinmetz, M.O, Schertler, G, Abela, R, Patthey, L, Schmitt, B, Hennig, M, Standfuss, J, Wang, M, Milne, J.C.
登録日2019-06-18
公開日2020-07-15
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Advances in long-wavelength native phasing at X-ray free-electron lasers.
Iucrj, 7, 2020
1GZM
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BU of 1gzm by Molmil
Structure of Bovine Rhodopsin in a Trigonal Crystal Form
分子名称: (HYDROXYETHYLOXY)TRI(ETHYLOXY)OCTANE, DI-PALMITOYL-3-SN-PHOSPHATIDYLETHANOLAMINE, LAURYL DIMETHYLAMINE-N-OXIDE, ...
著者Li, J.
登録日2002-05-24
公開日2003-11-20
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structure of Bovine Rhodopsin in a Trigonal Crystal Form
J.Mol.Biol., 343, 2004
7XNA
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BU of 7xna by Molmil
Crystal structure of somatostatin receptor 2 (SSTR2) with peptide antagonist CYN 154806
分子名称: CYN 154806, Somatostatin receptor type 2,Endo-1,4-beta-xylanase
著者Zhao, W, Han, S, Qiu, N, Feng, W, Lu, M, Yang, D, Wang, M.-W, Wu, B, Zhao, Q.
登録日2022-04-28
公開日2022-08-03
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献Structural insights into ligand recognition and selectivity of somatostatin receptors.
Cell Res., 32, 2022
6TQ9
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BU of 6tq9 by Molmil
Crystal structure of the Orexin-1 receptor in complex with SB-408124
分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-[6,8-bis(fluoranyl)-2-methyl-quinolin-4-yl]-3-[4-(dimethylamino)phenyl]urea, Orexin receptor type 1, ...
著者Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
登録日2019-12-16
公開日2020-01-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.655 Å)
主引用文献Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020
6TQ7
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Crystal structure of the Orexin-1 receptor in complex with SB-334867
分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea, Orexin receptor type 1, ...
著者Rappas, M, Ali, A, Bennett, K.A, Brown, J.D, Bucknell, S.J, Congreve, M, Cooke, R.M, Cseke, G, de Graaf, C, Dore, A.S, Errey, J.C, Jazayeri, A, Marshall, F.H, Mason, J.S, Mould, R, Patel, J.C, Tehan, B.G, Weir, M, Christopher, J.A.
登録日2019-12-16
公開日2020-01-01
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.6636 Å)
主引用文献Comparison of Orexin 1 and Orexin 2 Ligand Binding Modes Using X-ray Crystallography and Computational Analysis.
J.Med.Chem., 63, 2020
8IUK
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BU of 8iuk by Molmil
Cryo-EM structure of the PGF2-alpha-bound human PTGFR-Gq complex
分子名称: (Z)-7-[(1R,2R,3R,5S)-3,5-bis(oxidanyl)-2-[(E,3S)-3-oxidanyloct-1-enyl]cyclopentyl]hept-5-enoic acid, Antibody fragment scFv16, G subunit alpha (q), ...
著者Wu, C, Xu, Y, Xu, H.E.
登録日2023-03-24
公開日2023-07-12
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.67 Å)
主引用文献Ligand-induced activation and G protein coupling of prostaglandin F 2 alpha receptor.
Nat Commun, 14, 2023
8YKX
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BU of 8ykx by Molmil
Cryo-EM structure of succinate receptor SUCR1 bound to maleic acid
分子名称: Antibody fragment ScFv16, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Li, C, Liu, H, Li, J, Zhu, H, Fu, W, Xu, H.E.
登録日2024-03-05
公開日2024-05-29
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Molecular basis of ligand recognition and activation of the human succinate receptor SUCR1.
Cell Res., 2024
8IJA
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BU of 8ija by Molmil
Cryo-EM structure of human HCAR2-Gi complex with niacin
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Pan, X, Fang, Y.
登録日2023-02-26
公開日2024-01-03
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Structural insights into ligand recognition and selectivity of the human hydroxycarboxylic acid receptor HCAR2.
Cell Discov, 9, 2023
8E9W
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BU of 8e9w by Molmil
CryoEM structure of miniGq-coupled hM3Dq in complex with DCZ
分子名称: 11-(4-methylpiperazin-1-yl)-5H-dibenzo[b,e][1,4]diazepine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Zhang, S, Fay, J.F, Roth, B.L.
登録日2022-08-27
公開日2022-11-30
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
8E9Z
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BU of 8e9z by Molmil
CryoEM structure of miniGq-coupled hM3R in complex with Iperoxo
分子名称: 4-(4,5-dihydro-1,2-oxazol-3-yloxy)-N,N,N-trimethylbut-2-yn-1-aminium, CHOLESTEROL HEMISUCCINATE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Zhang, S, Fay, J.F, Roth, B.L.
登録日2022-08-27
公開日2022-11-30
最終更新日2022-12-21
実験手法ELECTRON MICROSCOPY (2.69 Å)
主引用文献Molecular basis for selective activation of DREADD-based chemogenetics.
Nature, 612, 2022
8IQ4
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BU of 8iq4 by Molmil
Cryo-EM structure of Carboprost-bound prostaglandin-F2-alpha receptor-miniGq-Nb35 complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ...
著者Lv, X, Gao, K, Nie, J, Zhang, X, Zhang, S, Ren, Y, Li, Q, Huang, J, Liu, L, Zhang, X, Sun, X, Zhang, W, Liu, X.
登録日2023-03-15
公開日2024-01-31
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structures of human prostaglandin F 2 alpha receptor reveal the mechanism of ligand and G protein selectivity.
Nat Commun, 14, 2023
8XZI
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BU of 8xzi by Molmil
Cryo-EM structure of the CMF-019-bound human APLNR-Gi complex
分子名称: (3~{S})-5-methyl-3-[[1-pentan-3-yl-2-(thiophen-2-ylmethyl)benzimidazol-5-yl]carbonylamino]hexanoic acid, Apelin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Wang, W, Ji, S, Zhang, Y.
登録日2024-01-21
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structure-based design of non-hypertrophic apelin receptor modulator.
Cell, 187, 2024
8YUU
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BU of 8yuu by Molmil
Cryo-EM structure of the histamine-bound H3R-Gi complex
分子名称: CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y.
登録日2024-03-27
公開日2024-06-05
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
8X8L
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BU of 8x8l by Molmil
Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
分子名称: Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
著者Xu, H.E, You, C, Zhao, L, Li, J.
登録日2023-11-27
公開日2024-06-12
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex
To Be Published
8YUT
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BU of 8yut by Molmil
Cryo-EM structure of the amthamine-bound H2R-Gs complex
分子名称: 5-(2-azanylethyl)-4-methyl-1,3-thiazol-2-amine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
著者Shen, Q, Tang, X, Wen, X, Cheng, S, Xiao, P, Zang, S, Shen, D, Jiang, L, Zheng, Y, Zhang, H, Xu, H, Mao, C, Zhang, M, Hu, W, Sun, J, Chen, Z, Zhang, Y.
登録日2024-03-27
公開日2024-06-05
最終更新日2024-07-03
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Molecular Determinant Underlying Selective Coupling of Primary G-Protein by Class A GPCRs.
Adv Sci, 11, 2024
8IRT
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BU of 8irt by Molmil
Dopamine Receptor D3R-Gi-Rotigotine complex
分子名称: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ...
著者Xu, P, Huang, S, Zhuang, Y, Mao, C, Zhang, Y, Wang, Y, Li, H, Jiang, Y, Zhang, Y, Xu, H.E.
登録日2023-03-19
公開日2023-06-07
最終更新日2023-11-08
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural genomics of the human dopamine receptor system.
Cell Res., 33, 2023
6IBL
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BU of 6ibl by Molmil
ACTIVATED TURKEY BETA1 ADRENOCEPTOR WITH BOUND AGONIST FORMOTEROL AND NANOBODY Nb80
分子名称: Camelid antibody fragment Nb80, HEGA-10, SODIUM ION, ...
著者Warne, T, Edwards, P.C, Dore, A.S, Leslie, A.G.W, Tate, C.G.
登録日2018-11-30
公開日2019-01-09
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Molecular basis of beta-arrestin coupling to formoterol-bound beta1-adrenoceptor.
Nature, 583, 2020
7NA8
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BU of 7na8 by Molmil
Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist
分子名称: 1-(methanesulfonyl)-1'-(2-methyl-L-alanyl-O-benzyl-D-seryl)-1,2-dihydrospiro[indole-3,4'-piperidine], Antibody fragment, CHOLESTEROL, ...
著者Liu, H, Sun, D, Sun, J, Zhang, C.
登録日2021-06-20
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Nat Commun, 12, 2021
7NA7
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Structures of human ghrelin receptor-Gi complexes with ghrelin and a synthetic agonist
分子名称: Antibody fragment, CHOLESTEROL, Ghrelin-27, ...
著者Liu, H, Sun, D, Sun, J, Zhang, C.
登録日2021-06-20
公開日2021-12-15
実験手法ELECTRON MICROSCOPY (2.7 Å)
主引用文献Structural basis of human ghrelin receptor signaling by ghrelin and the synthetic agonist ibutamoren
Nat Commun, 12, 2021
2VT4
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BU of 2vt4 by Molmil
TURKEY BETA1 ADRENERGIC RECEPTOR WITH STABILISING MUTATIONS AND BOUND CYANOPINDOLOL
分子名称: 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile, BETA1 ADRENERGIC RECEPTOR, DECANE, ...
著者Warne, A, Serrano-Vega, M.J, Baker, J.G, Moukhametzianov, R, Edwards, P.C, Henderson, R, Leslie, A.G.W, Tate, C.G, Schertler, G.F.X.
登録日2008-05-09
公開日2008-06-24
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure of a Beta1-Adrenergic G-Protein-Coupled Receptor.
Nature, 454, 2008
4XNW
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BU of 4xnw by Molmil
The human P2Y1 receptor in complex with MRS2500
分子名称: P2Y purinoceptor 1,Rubredoxin,P2Y purinoceptor 1, ZINC ION, [(1R,2S,4S,5S)-4-[2-iodo-6-(methylamino)-9H-purin-9-yl]-2-(phosphonooxy)bicyclo[3.1.0]hex-1-yl]methyl dihydrogen phosphate
著者Zhang, D, Gao, Z, Jacobson, K, Han, G.W, Stevens, R, Zhao, Q, Wu, B, GPCR Network (GPCR)
登録日2015-01-16
公開日2015-04-01
最終更新日2020-02-05
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Two disparate ligand-binding sites in the human P2Y1 receptor
Nature, 520, 2015
7ZL9
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BU of 7zl9 by Molmil
Crystal structure of human GPCR Niacin receptor (HCA2)
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, DI(HYDROXYETHYL)ETHER, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, ...
著者Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, Han, G.W, FiBerto, J.F, Wu, L.J, Tong, J.H, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J.
登録日2022-04-14
公開日2023-04-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural insights into the human niacin receptor HCA2-G i signalling complex.
Nat Commun, 14, 2023
7ZLY
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Crystal structure of human GPCR Niacin receptor (HCA2) expressed from Spodoptera frugiperda
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Hydroxycarboxylic acid receptor 2,Soluble cytochrome b562, OLEIC ACID
著者Yang, Y, Kang, H.J, Gao, R.G, Wang, J.J, FiBerto, J.F, Wu, L.J, Tong, J.H, Han, G.W, Qu, L, Wu, Y.R, Pileski, R, Li, X.M, Zhang, X.C, Zhao, S.W, Kenakin, T, Wang, Q, Stevens, R.C, Peng, W, Roth, B.L, Rao, Z.H, Liu, Z.J.
登録日2022-04-17
公開日2023-04-12
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural insights into the human niacin receptor HCA2-G i signalling complex.
Nat Commun, 14, 2023
6RZ4
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Crystal structure of cysteinyl leukotriene receptor 1 in complex with pranlukast
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Cysteinyl leukotriene receptor 1,Soluble cytochrome b562,Cysteinyl leukotriene receptor 1, OLEIC ACID, ...
著者Luginina, A, Gusach, A, Marin, E, Mishin, A, Brouillette, R, Popov, P, Shiryaeva, A, Besserer-Offroy, E, Longpre, J.M, Lyapina, E, Ishchenko, A, Patel, N, Polovinkin, V, Safronova, N, Bogorodskiy, A, Edelweiss, E, Liu, W, Batyuk, A, Gordeliy, V, Han, G.W, Sarret, P, Katritch, V, Borshchevskiy, V, Cherezov, V.
登録日2019-06-12
公開日2019-10-30
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structure-based mechanism of cysteinyl leukotriene receptor inhibition by antiasthmatic drugs.
Sci Adv, 5, 2019

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