PDB: 156 件ウェブページステータス検索Chemie searchBIRD

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4ERF	crystal structure of MDM2 (17-111) in complex with compound 29 (AM-8553) 分子名称: E3 ubiquitin-protein ligase Mdm2, {(3R,5R,6S)-5-(3-chlorophenyl)-6-(4-chlorophenyl)-1-[(2S,3S)-2-hydroxypentan-3-yl]-3-methyl-2-oxopiperidin-3-yl}acetic acid 著者 Huang, X. 登録日 2012-04-20 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure-based design of novel inhibitors of the MDM2-p53 interaction. J.Med.Chem., 55, 2012
4ERE	crystal structure of MDM2 (17-111) in complex with compound 23 分子名称: E3 ubiquitin-protein ligase Mdm2, SULFATE ION, [(3R,5R,6S)-1-[(2S)-1-tert-butoxy-1-oxobutan-2-yl]-5-(3-chlorophenyl)-6-(4-chlorophenyl)-2-oxopiperidin-3-yl]acetic acid 著者 Huang, X. 登録日 2012-04-20 公開日 2012-05-23 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of novel inhibitors of the MDM2-p53 interaction. J.Med.Chem., 55, 2012
4DIJ	The Central Valine Concept Provides an Entry in a New Class of Non Peptide Inhibitors of the P53-MDM2 Interaction 分子名称: 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-N-[2-(morpholin-4-yl)ethyl]-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2 著者 Kallen, J. 登録日 2012-01-31 公開日 2012-05-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 The central valine concept provides an entry in a new class of non peptide inhibitors of the p53-MDM2 interaction. Bioorg.Med.Chem.Lett., 22, 2012
3V3B	Structure of the Stapled p53 Peptide Bound to Mdm2 分子名称: CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, SAH-p53-8 stapled-peptide 著者 Baek, S, Kutchukian, P.S, Verdine, G.L, Huber, R, Holak, T.A, Ki Won, L, Popowicz, G.M. 登録日 2011-12-13 公開日 2012-01-18 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the stapled p53 peptide bound to Mdm2. J.Am.Chem.Soc., 134, 2012
3TU1	Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist 分子名称: 3-[(1S)-2-(tert-butylamino)-1-{N-[(3,4-difluorophenyl)methyl]formamido}-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2 著者 Wolf, S, Huang, Y, Koes, D, Popowicz, G.M, Camacho, C.J, Holak, T.A, Doemling, A. 登録日 2011-09-15 公開日 2011-11-02 最終更新日 2024-05-29 実験手法 X-RAY DIFFRACTION (1.603 Å) 主引用文献 Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists. Chemmedchem, 7, 2012
3IWY	Crystal structure of human MDM2 complexed with D-peptide (12 residues) 分子名称: D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2 著者 Pazgier, M, Lu, W. 登録日 2009-09-03 公開日 2010-04-21 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 D-peptide inhibitors of the p53-MDM2 interaction for targeted molecular therapy of malignant neoplasms. Proc.Natl.Acad.Sci.USA, 398, 2010
3LBL	Structure of human MDM2 protein in complex with Mi-63-analog 分子名称: (2'R,3R,4'R,5'R)-6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(2-morpholin-4-ylethyl)-2-oxo-1,2-dihydrospiro[indole-3,3'-pyrrolidine]-5'-carboxamide, E3 ubiquitin-protein ligase Mdm2 著者 Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. 登録日 2010-01-08 公開日 2010-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
3LBK	Structure of human MDM2 protein in complex with a small molecule inhibitor 分子名称: 6-chloro-3-[1-(4-chlorobenzyl)-4-phenyl-1H-imidazol-5-yl]-1H-indole-2-carboxylic acid, E3 ubiquitin-protein ligase Mdm2, SULFATE ION 著者 Popowicz, G.M, Czarna, A, Wolf, S, Holak, T.A. 登録日 2010-01-08 公開日 2010-03-16 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structures of low molecular weight inhibitors bound to MDMX and MDM2 reveal new approaches for p53-MDMX/MDM2 antagonist drug discovery Cell Cycle, 9, 2010
3LNZ	Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant) 分子名称: 12-mer peptide inhibitor, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2 著者 Pazgier, M, Lu, W. 登録日 2010-02-03 公開日 2010-03-09 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J.Mol.Biol., 398, 2010
3LNJ	Crystal structure of human MDM2 in complex with D-peptide inhibitor (DPMI-alpha) 分子名称: CHLORIDE ION, D-peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, ... 著者 Pazgier, M, Lu, W. 登録日 2010-02-02 公開日 2010-03-09 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 A left-handed solution to peptide inhibition of the p53-MDM2 interaction. Angew.Chem.Int.Ed.Engl., 49, 2010
3JZK	crystal structure of MDM2 with chromenotriazolopyrimidine 1 分子名称: (6R,7S)-6,7-bis(4-bromophenyl)-7,11-dihydro-6H-chromeno[4,3-d][1,2,4]triazolo[1,5-a]pyrimidine, E3 ubiquitin-protein ligase Mdm2 著者 Huang, X. 登録日 2009-09-23 公開日 2009-11-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Discovery and optimization of chromenotriazolopyrimidines as potent inhibitors of the mouse double minute 2-tumor protein 53 protein-protein interaction. J.Med.Chem., 52, 2009
3JZS	Human MDM2 liganded with a 12mer peptide inhibitor (pDIQ) 分子名称: 1,2-ETHANEDIOL, E3 ubiquitin-protein ligase Mdm2, pDIQ peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3JZR	Human MDM2 liganded with a 12mer peptide inhibitor (pDI6W) 分子名称: E3 ubiquitin-protein ligase Mdm2, pDI6W peptide (12mer) 著者 Schonbrunn, E, Phan, J. 登録日 2009-09-24 公開日 2009-11-10 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX. J.Biol.Chem., 285, 2010
3IUX	Crystal structure of human MDM2 in complex with a potent miniature protein inhibitor (18-residues) 分子名称: ACETATE ION, CHLORIDE ION, E3 ubiquitin-protein ligase Mdm2, ... 著者 Pazgier, M, Lu, W. 登録日 2009-08-31 公開日 2009-10-27 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Apamin as a template for structure-based rational design of potent peptide activators of p53. Angew.Chem.Int.Ed.Engl., 48, 2009
3G03	Structure of human MDM2 in complex with high affinity peptide 分子名称: E3 ubiquitin-protein ligase Mdm2, High affinity synthetic peptide 著者 Czarna, A.L, Popowicz, G.M, Holak, T.A. 登録日 2009-01-27 公開日 2009-04-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 High affinity interaction of the p53 peptide-analogue with human Mdm2 and Mdmx. Cell Cycle, 8, 2009
3EQS	Crystal structure of human MDM2 in complex with a 12-mer peptide inhibitor 分子名称: 12-mer peptide inhibitor, E3 ubiquitin-protein ligase Mdm2, GUANIDINE 著者 Pazgier, M, Lu, W. 登録日 2008-10-01 公開日 2009-03-17 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of p53 interactions with MDM2 and MDMX. Proc.Natl.Acad.Sci.USA, 106, 2009
3DAC	Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Holak, T.A. 登録日 2008-05-29 公開日 2008-09-02 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure of the human Mdmx protein bound to the p53 tumor suppressor transactivation domain. Cell Cycle, 7, 2008
2Z5S	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2Z5T	Molecular basis for the inhibition of p53 by Mdmx 分子名称: Cellular tumor antigen p53, Mdm4 protein 著者 Popowicz, G.M, Czarna, A, Rothweiler, U, Szwagierczak, A, Holak, T.A. 登録日 2007-07-17 公開日 2007-11-06 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Molecular basis for the inhibition of p53 by Mdmx. Cell Cycle, 6, 2007
2GV2	MDM2 in complex with an 8-mer p53 peptide analogue 分子名称: 8-MER P53 PEPTIDE ANALOGUE, E3 ubiquitin-protein ligase Mdm2 著者 Schubert, C, Sakurai, K. 登録日 2006-05-02 公開日 2006-09-05 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystallographic Analysis of an 8-mer p53 Peptide Analogue Complexed with MDM2. J.Am.Chem.Soc., 128, 2006
2AXI	HDM2 in complex with a beta-hairpin 分子名称: 3[N-MORPHOLINO]PROPANE SULFONIC ACID, SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, ... 著者 Mittl, P.R.E, Fasan, R, Robinson, J, Gruetter, M.G. 登録日 2005-09-05 公開日 2006-03-21 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Structure-Activity Studies in a Family of beta-Hairpin Protein Epitope Mimetic Inhibitors of the p53-HDM2 Protein-Protein Interaction. Chembiochem, 7, 2006
1Z1M	NMR structure of unliganded MDM2 分子名称: Ubiquitin-protein ligase E3 Mdm2 著者 Uhrinova, S, Uhrin, D, Powers, H, Watt, K, Zheleva, D, Fischer, P, McInnes, C, Barlow, P.N. 登録日 2005-03-04 公開日 2005-06-28 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Structure of Free MDM2 N-terminal Domain Reveals Conformational Adjustments that Accompany p53-binding J.Mol.Biol., 350, 2005
1T4F	Structure of human MDM2 in complex with an optimized p53 peptide 分子名称: SULFATE ION, Ubiquitin-protein ligase E3 Mdm2, optimized p53 peptide 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1T4E	Structure of Human MDM2 in complex with a Benzodiazepine Inhibitor 分子名称: (4-CHLOROPHENYL)[3-(4-CHLOROPHENYL)-7-IODO-2,5-DIOXO-1,2,3,5-TETRAHYDRO-4H-1,4-BENZODIAZEPIN-4-YL]ACETIC ACID, Ubiquitin-protein ligase E3 Mdm2 著者 Grasberger, B.L, Schubert, C, Koblish, H.K, Carver, T.E, Franks, C.F, Zhao, S.Y, Lu, T, LaFrance, L.V, Parks, D.J. 登録日 2004-04-29 公開日 2005-02-08 最終更新日 2023-08-23 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Discovery and cocrystal structure of benzodiazepinedione HDM2 antagonists that activate p53 in cells J.Med.Chem., 48, 2005
1TTV	NMR Structure of a Complex Between MDM2 and a Small Molecule Inhibitor 分子名称: 1-{[4,5-BIS(4-CHLOROPHENYL)-2-(2-ISOPROPOXY-4-METHOXYPHENYL)-4,5-DIHYDRO-1H-IMIDAZOL-1-YL]CARBONYL}PIPERAZINE, Ubiquitin-protein ligase E3 Mdm2 著者 Fry, D.C, Emerson, S.D, Palme, S, Vu, B.T, Liu, C.M, Podlaski, F. 登録日 2004-06-23 公開日 2005-01-04 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 NMR structure of a complex between MDM2 and a small molecule inhibitor. J.Biomol.Nmr, 30, 2004

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