3LNZ

Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant)

Summary for 3LNZ

Entry DOI	10.2210/pdb3lnz/pdb
Related	1YCR 3EQS 3IUX 3LNJ 3LO1 3LO2 3LO4 3LO9 3LOE
Descriptor	E3 ubiquitin-protein ligase Mdm2, 12-mer peptide inhibitor, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	p53-binding protein of mdm2, oncoprotein mdm2, human double minute 2 protein, hdm2, mdm2-peptide inhibitor complex, p53 peptide activator n8a-pmi, host-virus interaction, ligase, metal-binding, nucleus, phosphoprotein, proto-oncogene, ubl conjugation pathway, zinc-finger, ligase-ligase inhibitor complex, ligase/ligase inhibitor
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	16
Total formula weight	91718.99
Authors	Pazgier, M.,Lu, W. (deposition date: 2010-02-03, release date: 2010-03-09, Last modification date: 2023-09-06)
Primary citation	Li, C.,Pazgier, M.,Li, C.,Yuan, W.,Liu, M.,Wei, G.,Lu, W.Y.,Lu, W. Systematic mutational analysis of peptide inhibition of the p53-MDM2/MDMX interactions. J.Mol.Biol., 398:200-213, 2010 Cited by PubMed: 20226197 DOI: 10.1016/j.jmb.2010.03.005 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation