3LO9

Crystal structure of human alpha-defensin 1 (W26Ahp mutant)

Summary for 3LO9

Entry DOI	10.2210/pdb3lo9/pdb
Related	3GNY 3LO1 3LO2 3LO4 3LO6 3LOE
Descriptor	Neutrophil defensin 1 (2 entities in total)
Functional Keywords	antimicrobial peptide, human alpha defensin 1, human neutrophil peptide 1, hnp1, antibiotic, antimicrobial, antiviral defense, defensin, disulfide bond, fungicide, phosphoprotein, secreted, antimicrobial protein
Cellular location	Secreted: P59665
Total number of polymer chains	2
Total formula weight	6786.17
Authors	Pazgier, M.,Lu, W. (deposition date: 2010-02-03, release date: 2010-03-09, Last modification date: 2023-09-06)
Primary citation	Wei, G.,Pazgier, M.,de Leeuw, E.,Rajabi, M.,Li, J.,Zou, G.,Jung, G.,Yuan, W.,Lu, W.Y.,Lehrer, R.I.,Lu, W. Trp-26 imparts functional versatility to human alpha-defensin HNP1. J.Biol.Chem., 285:16275-16285, 2010 Cited by PubMed: 20220136 DOI: 10.1074/jbc.M110.102749 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.56 Å)

Structure validation