3LNZ

Crystal structure of human MDM2 with a 12-mer peptide inhibitor PMI (N8A mutant)

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005634	cellular_component	nucleus
A	0043066	biological_process	negative regulation of apoptotic process
A	0051726	biological_process	regulation of cell cycle
C	0005634	cellular_component	nucleus
C	0043066	biological_process	negative regulation of apoptotic process
C	0051726	biological_process	regulation of cell cycle
E	0005634	cellular_component	nucleus
E	0043066	biological_process	negative regulation of apoptotic process
E	0051726	biological_process	regulation of cell cycle
G	0005634	cellular_component	nucleus
G	0043066	biological_process	negative regulation of apoptotic process
G	0051726	biological_process	regulation of cell cycle
I	0005634	cellular_component	nucleus
I	0043066	biological_process	negative regulation of apoptotic process
I	0051726	biological_process	regulation of cell cycle
K	0005634	cellular_component	nucleus
K	0043066	biological_process	negative regulation of apoptotic process
K	0051726	biological_process	regulation of cell cycle
M	0005634	cellular_component	nucleus
M	0043066	biological_process	negative regulation of apoptotic process
M	0051726	biological_process	regulation of cell cycle
O	0005634	cellular_component	nucleus
O	0043066	biological_process	negative regulation of apoptotic process
O	0051726	biological_process	regulation of cell cycle

Functional Information from PDB Data

site_id	AC1
Number of Residues	1
Details	BINDING SITE FOR RESIDUE CL A 5

Chain	Residue
A	GLN44

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site_id	AC2
Number of Residues	3
Details	BINDING SITE FOR RESIDUE CL C 8

Chain	Residue
C	GLN44
C	LYS45
C	TYR56

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site_id	AC3
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL E 2

Chain	Residue
E	GLN44
E	LYS45
E	HOH303
H	HOH469

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site_id	AC4
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL G 4

Chain	Residue
G	TYR56
G	GLN44

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site_id	AC5
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL I 1

Chain	Residue
I	GLN44
I	HOH437

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site_id	AC6
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL K 7

Chain	Residue
K	ALA43
K	GLN44

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site_id	AC7
Number of Residues	2
Details	BINDING SITE FOR RESIDUE CL M 3

Chain	Residue
M	PRO32
M	LEU33

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site_id	AC8
Number of Residues	4
Details	BINDING SITE FOR RESIDUE CL M 6

Chain	Residue
M	GLN44
M	TYR48
M	HOH190
M	HOH438

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	166
Details	Domain: {"description":"SWIB/MDM2","evidences":[{"source":"PROSITE-ProRule","id":"PRU01273","evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

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