3TU1

Exhaustive Fluorine Scanning towards Potent p53-MDM2 Antagonist

Summary for 3TU1

Entry DOI	10.2210/pdb3tu1/pdb
Descriptor	E3 ubiquitin-protein ligase Mdm2, 3-[(1S)-2-(tert-butylamino)-1-{N-[(3,4-difluorophenyl)methyl]formamido}-2-oxoethyl]-6-chloro-1H-indole-2-carboxylic acid (3 entities in total)
Functional Keywords	p53-binding protein mdm2, oncoprotein mdm2, double minute 2 protein, hdm2, oncoprotein, p53, nucleus, ligase
Biological source	Homo sapiens (human)
Cellular location	Nucleus, nucleoplasm: Q00987
Total number of polymer chains	1
Total formula weight	12926.16
Authors	Wolf, S.,Huang, Y.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Doemling, A. (deposition date: 2011-09-15, release date: 2011-11-02, Last modification date: 2024-05-29)
Primary citation	Huang, Y.,Wolf, S.,Koes, D.,Popowicz, G.M.,Camacho, C.J.,Holak, T.A.,Domling, A. Exhaustive Fluorine Scanning toward Potent p53-Mdm2 Antagonists. Chemmedchem, 7:49-52, 2012 Cited by PubMed: 21954050 DOI: 10.1002/cmdc.201100428 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.603 Å)

Structure validation