5OAF
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![BU of 5oaf by Molmil](/molmil-images/mine/5oaf) | Human Rvb1/Rvb2 heterohexamer in INO80 complex | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, RuvB-like 1, RuvB-like 2 | 著者 | Aramayo, R.J, Bythell-Douglas, R, Ayala, R, Willhoft, O, Wigley, D, Zhang, X. | 登録日 | 2017-06-21 | 公開日 | 2017-12-13 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (4.06 Å) | 主引用文献 | Cryo-EM structures of the human INO80 chromatin-remodeling complex. Nat. Struct. Mol. Biol., 25, 2018
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6V74
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6TTF
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![BU of 6ttf by Molmil](/molmil-images/mine/6ttf) | PKM2 in complex with Compound 5 | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, 5-hydroxynaphthalene-1-sulfonamide, Pyruvate kinase PKM | 著者 | Saur, M, Hartshorn, M.J, Dong, J, Reeks, J, Bunkoczi, G, Jhoti, H, Williams, P.A. | 登録日 | 2019-12-27 | 公開日 | 2020-01-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Fragment-based drug discovery using cryo-EM. Drug Discov Today, 25, 2020
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6V4X
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![BU of 6v4x by Molmil](/molmil-images/mine/6v4x) | Cryo-EM structure of an active human histone pre-mRNA 3'-end processing machinery at 3.2 Angstrom resolution | 分子名称: | Cleavage and polyadenylation specificity factor subunit 2, Cleavage and polyadenylation specificity factor subunit 3, Small nuclear ribonucleoprotein E, ... | 著者 | Sun, Y, Zhang, Y, Walz, T, Tong, L. | 登録日 | 2019-12-02 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structure of an active human histone pre-mRNA 3'-end processing machinery. Science, 367, 2020
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6V75
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6V2K
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![BU of 6v2k by Molmil](/molmil-images/mine/6v2k) | The nucleosome structure after H2A-H2B exchange | 分子名称: | CHLORIDE ION, DNA (146-MER), Histone H2A, ... | 著者 | Arimura, Y, Hirano, R, Kurumizaka, H. | 登録日 | 2019-11-24 | 公開日 | 2020-11-25 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Histone variant H2A.B-H2B dimers are spontaneously exchanged with canonical H2A-H2B in the nucleosome. Commun Biol, 4, 2021
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6WP3
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![BU of 6wp3 by Molmil](/molmil-images/mine/6wp3) | Pyruvate Kinase M2 Mutant-K433Q | 分子名称: | CHLORIDE ION, GLYCEROL, MAGNESIUM ION, ... | 著者 | Nandi, S, Razzaghi, M, Srivastava, D, Dey, M. | 登録日 | 2020-04-26 | 公開日 | 2020-10-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.84 Å) | 主引用文献 | Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation. J.Biol.Chem., 295, 2020
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6WP5
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![BU of 6wp5 by Molmil](/molmil-images/mine/6wp5) | Pyruvate Kinase M2 mutant-S37D | 分子名称: | 1,6-di-O-phosphono-beta-D-fructofuranose, GLYCEROL, MAGNESIUM ION, ... | 著者 | Nandi, S, Razzaghi, M, Srivastava, D, Dey, M. | 登録日 | 2020-04-26 | 公開日 | 2020-09-30 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.17 Å) | 主引用文献 | Structural basis for allosteric regulation of pyruvate kinase M2 by phosphorylation and acetylation. J.Biol.Chem., 295, 2020
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4TVQ
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![BU of 4tvq by Molmil](/molmil-images/mine/4tvq) | CCM3 in complex with CCM2 LD-like motif | 分子名称: | Cerebral cavernous malformations 2 protein, Cerebral cavernous malformations 3 protein | 著者 | Li, X, Zhang, R, Fisher, O.S, Boggon, T.J. | 登録日 | 2014-06-27 | 公開日 | 2015-03-25 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | CCM2-CCM3 interaction stabilizes their protein expression and permits endothelial network formation. J.Cell Biol., 208, 2015
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4TZ4
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![BU of 4tz4 by Molmil](/molmil-images/mine/4tz4) | Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide | 分子名称: | DNA damage-binding protein 1, Protein cereblon, S-Lenalidomide, ... | 著者 | Chamberlain, P.P, Pagarigan, B, Delker, S, Leon, B, Riley, M. | 登録日 | 2014-07-09 | 公開日 | 2014-08-06 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3.01 Å) | 主引用文献 | Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex To Be Published
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4UG0
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![BU of 4ug0 by Molmil](/molmil-images/mine/4ug0) | STRUCTURE OF THE HUMAN 80S RIBOSOME | 分子名称: | 18S ribosomal RNA, 28S ribosomal RNA, 40S RIBOSOMAL PROTEIN, ... | 著者 | Khatter, H, Myasnikov, A.G, Natchiar, S.K, Klaholz, B.P. | 登録日 | 2015-03-20 | 公開日 | 2015-06-10 | 最終更新日 | 2019-12-18 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structure of the human 80S ribosome NATURE, 520, 2015
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4UND
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![BU of 4und by Molmil](/molmil-images/mine/4und) | HUMAN ARTD1 (PARP1) - CATALYTIC DOMAIN IN COMPLEX WITH INHIBITOR TALAZOPARIB | 分子名称: | (8S,9R)-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1H-1,2,4-triazol-5-yl)-2,7,8,9-tetrahydro-3H-pyrido[4,3,2-de]phthalazin-3-one, POLY [ADP-RIBOSE] POLYMERASE 1, SODIUM ION | 著者 | Karlberg, T, Thorsell, A.G, Ekblad, T, Klepsch, M, Pinto, A.F, Tresaugues, L, Moche, M, Schuler, H. | 登録日 | 2014-05-27 | 公開日 | 2015-06-17 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural Basis for Potency and Promiscuity in Poly(ADP-ribose) Polymerase (PARP) and Tankyrase Inhibitors. J. Med. Chem., 60, 2017
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4UP1
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4UI9
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![BU of 4ui9 by Molmil](/molmil-images/mine/4ui9) | Atomic structure of the human Anaphase-Promoting Complex | 分子名称: | ANAPHASE-PROMOTING COMPLEX SUBUNIT 1, ANAPHASE-PROMOTING COMPLEX SUBUNIT 10, ANAPHASE-PROMOTING COMPLEX SUBUNIT 11, ... | 著者 | Chang, L, Zhang, Z, Yang, J, McLaughlin, S.H, Barford, D. | 登録日 | 2015-03-27 | 公開日 | 2015-06-17 | 最終更新日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Atomic Structure of the Apc and its Mechanism of Protein Ubiquitination Nature, 522, 2015
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4UIY
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![BU of 4uiy by Molmil](/molmil-images/mine/4uiy) | N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH N-(1,1-dioxo-1-thian-4-yl)- 5-methyl-4-oxo-7-3-(trifluoromethyl)phenyl-4H,5H-thieno-3,2-c- pyridine-2-carboximidamide | 分子名称: | 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 4, N-[1,1-bis(oxidanylidene)thian-4-yl]-5-methyl-4-oxidanylidene-7-[3-(trifluoromethyl)phenyl]thieno[3,2-c]pyridine-2-carboximidamide | 著者 | Chung, C, Theodoulou, N.T, Bamborough, P, Humphreys, P.G. | 登録日 | 2015-04-03 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J.Med.Chem., 59, 2016
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4UIX
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![BU of 4uix by Molmil](/molmil-images/mine/4uix) | N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 7-(3,4-dimethoxyphenyl)-N-(1,1-dioxo-1-thian-4-yl)-5-methyl-4-oxo-4H,5H-thieno-3,2-c-pyridine-2- carboxamide | 分子名称: | 1,2-ETHANEDIOL, BROMODOMAIN-CONTAINING PROTEIN 4, CALCIUM ION, ... | 著者 | Chung, C, Theodoulou, N.T, Bamborough, P, Humphreys, P.G. | 登録日 | 2015-04-03 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J.Med.Chem., 59, 2016
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4UIZ
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![BU of 4uiz by Molmil](/molmil-images/mine/4uiz) | N-TERMINAL BROMODOMAIN OF HUMAN BRD4 WITH 7-(3,4-dimethoxyphenyl)-2-(4-methanesulfonylpiperazine-1-carbonyl)-5-methyl-4H,5H-thieno-3,2-c- pyridin-4-one | 分子名称: | 1,2-ETHANEDIOL, 7-(3,4-dimethoxyphenyl)-5-methyl-2-(4-methylsulfonylpiperazin-1-yl)carbonyl-thieno[3,2-c]pyridin-4-one, BROMODOMAIN-CONTAINING PROTEIN 4 | 著者 | Chung, C, Theodoulou, N.T, Bamborough, P, Humphreys, P.G. | 登録日 | 2015-04-03 | 公開日 | 2015-04-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.19 Å) | 主引用文献 | The Discovery of I-Brd9, a Selective Cell Active Chemical Probe for Bromodomain Containing Protein 9 Inhibition. J.Med.Chem., 59, 2016
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4UV8
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![BU of 4uv8 by Molmil](/molmil-images/mine/4uv8) | LSD1(KDM1A)-CoREST in complex with 1-Benzyl-Tranylcypromine | 分子名称: | LYSINE-SPECIFIC HISTONE DEMETHYLASE 1A, REST COREPRESSOR 1, [[(2R,3S,4S)-5-[(4aS,10aS)-4a-[(1S)-3-azanylidene-1,4-diphenyl-butyl]-7,8-dimethyl-2,4-bis(oxidanylidene)-5,10a-dihydro-1H-benzo[g]pteridin-10-yl]-2,3,4-tris(oxidanyl)pentoxy]-oxidanyl-phosphoryl] [(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methyl hydrogen phosphate | 著者 | Vianello, P, Botrugno, O, Cappa, A, Ciossani, G, Dessanti, P, Mai, A, Mattevi, A, Meroni, G, Minucci, S, Thaler, F, Tortorici, M, Trifiro, P, Valente, S, Villa, M, Varasi, M, Mercurio, C. | 登録日 | 2014-08-05 | 公開日 | 2014-09-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Synthesis, Biological Activity and Mechanistic Insights of 1-Substituted Cyclopropylamine Derivatives: A Novel Class of Irreversible Inhibitors of Histone Demethylase Kdm1A. Eur.J.Med.Chem., 86C, 2014
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4V98
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![BU of 4v98 by Molmil](/molmil-images/mine/4v98) | The 8S snRNP Assembly Intermediate | 分子名称: | CG10419, Icln, LD23602p, ... | 著者 | Grimm, C, Pelz, J.P, Schindelin, H, Diederichs, K, Kuper, J, Kisker, C. | 登録日 | 2012-05-15 | 公開日 | 2014-07-09 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural Basis of Assembly Chaperone- Mediated snRNP Formation. Mol.Cell, 49, 2013
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4USG
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![BU of 4usg by Molmil](/molmil-images/mine/4usg) | Crystal structure of PC4 W89Y mutant complex with DNA | 分子名称: | 5'-D(*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP *TP*TP*TP*TP*TP*G)-3', ACTIVATED RNA POLYMERASE II TRANSCRIPTIONAL COACTIVATOR P15 | 著者 | Zhao, Y, Liu, J. | 登録日 | 2014-07-08 | 公開日 | 2015-03-18 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.973 Å) | 主引用文献 | Substitution of Tryptophan 89 with Tyrosine Switches the DNA Binding Mode of Pc4. Sci.Rep., 5, 2015
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4O1U
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4O3M
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![BU of 4o3m by Molmil](/molmil-images/mine/4o3m) | Ternary complex of Bloom's syndrome helicase | 分子名称: | 1,2-ETHANEDIOL, 5'-D(*AP*GP*CP*GP*TP*CP*GP*AP*GP*AP*TP*CP*CP*AP*AP*G)-3', 5'-D(*CP*TP*TP*GP*GP*AP*TP*CP*TP*CP*GP*AP*CP*GP*CP*TP*CP*TP*CP*CP*CP*TP*TP*A)-3', ... | 著者 | Swan, M.K, Bertrand, J. | 登録日 | 2013-12-18 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structure of human Bloom's syndrome helicase in complex with ADP and duplex DNA. Acta Crystallogr.,Sect.D, 70, 2014
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4O63
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![BU of 4o63 by Molmil](/molmil-images/mine/4o63) | Co-enzyme Induced Conformational Changes in Bovine Eye Glyceraldehyde 3-Phosphate Dehydrogenase | 分子名称: | Glyceraldehyde-3-phosphate dehydrogenase, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | 著者 | Baker, B.Y, Shi, W, Wang, B, Palczewski, K. | 登録日 | 2013-12-20 | 公開日 | 2014-09-24 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | High-resolution crystal structures of the photoreceptor glyceraldehyde 3-phosphate dehydrogenase (GAPDH) with three and four-bound NAD molecules. Protein Sci., 23, 2014
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4O70
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![BU of 4o70 by Molmil](/molmil-images/mine/4o70) | Crystal structure of the first bromodomain of human BRD4 in complex with DINACICLIB | 分子名称: | 1,2-ETHANEDIOL, 3-[({3-ethyl-5-[(2S)-2-(2-hydroxyethyl)piperidin-1-yl]pyrazolo[1,5-a]pyrimidin-7-yl}amino)methyl]-1-hydroxypyridinium, Bromodomain-containing protein 4 | 著者 | Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. | 登録日 | 2013-12-24 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
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4O7F
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![BU of 4o7f by Molmil](/molmil-images/mine/4o7f) | Crystal structure of the first bromodomain of human BRD4 in complex with SB-251527 | 分子名称: | 1,2-ETHANEDIOL, 4-[4-(4-fluorophenyl)-1-(piperidin-4-yl)-1H-imidazol-5-yl]-2-(2-methoxyphenoxy)pyrimidine, Bromodomain-containing protein 4, ... | 著者 | Ember, S.W, Zhu, J.-Y, Watts, C, Schonbrunn, E. | 登録日 | 2013-12-24 | 公開日 | 2014-03-05 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors. Acs Chem.Biol., 9, 2014
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