4TZ4

Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide

Summary for 4TZ4

• Entry DOI: 10.2210/pdb4tz4/pdb
• Related: 4TZC 4TZU
• Descriptor: DNA damage-binding protein 1, Protein cereblon, ZINC ION, ... (5 entities in total)
• Functional Keywords: dcaf, dna binding protein-ligase complex, dna binding protein/ligase
• Biological source: Homo sapiens (Human); More
• Cellular location: Cytoplasm: Q16531 Q96SW2
• Total number of polymer chains: 2
• Total formula weight: 172071.28

Authors

Chamberlain, P.P.,Pagarigan, B.,Delker, S.,Leon, B.,Riley, M. (deposition date: 2014-07-09, release date: 2014-08-06, Last modification date: 2024-04-03)

• Primary citation: Chamberlain, P.P.,Wang, M.,Riley, M.,Delker, S.,Carmel, G.,Miller, K.,Lopez-Girona, A.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Lopez-Girona, A.,Ren, Y.,Wang, M.,Riley, M.,Delker, S.,Ito, T.,Hideki, A.,Mori, T.,Handa, H.,Hakoshima, T.,Daniel, T.O.,Miller, K.,Cathers, B.E.,Carmel, G.,Pagarigan, B.,Leon, B.,Rychak, E.,Corral, L.,Ren, Y.; Structural Basis for Responsiveness to Thalidomide-Analog Drugs Defined by the Crystal Structure of the Human Cereblon:DDB1:Lenalidomide Complex; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.01 Å)