4TZ4
Crystal Structure of Human Cereblon in Complex with DDB1 and Lenalidomide
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | DNA damage-binding protein 1 | polymer | 1146 | 127879.2 | 1 | UniProt (Q16531) Pfam (PF10433) Pfam (PF03178) | Homo sapiens (Human) | DDB p127 subunit,DNA damage-binding protein a,DDBa,Damage-specific DNA-binding protein 1,HBV X-associated protein 1,XAP-1,UV-damaged DNA-binding factor,UV-damaged DNA-binding protein 1,UV-DDB 1,XPE-binding factor,XPE-BF,Xeroderma pigmentosum group E-complementing protein,XPCe |
| 2 | B (C) | Protein cereblon | polymer | 381 | 43867.4 | 1 | UniProt (Q96SW2) Pfam (PF02190) Pfam (PF03226) | Homo sapiens (Human) | |
| 3 | C (C) | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
| 4 | D (C) | S-Lenalidomide | non-polymer | 259.3 | 1 | Chemie (LVY) | |||
| 5 | E, F (A, C) | water | water | 18.0 | 18 | Chemie (HOH) |
Sequence modifications
A: 2 - 1140 (UniProt: Q16531)
| PDB | External Database | Details |
|---|---|---|
| Trp 1141 | - | expression tag |
| Ser 1142 | - | expression tag |
| His 1143 | - | expression tag |
| Pro 1144 | - | expression tag |
| Gln 1145 | - | expression tag |
| Phe 1146 | - | expression tag |
| Glu 1147 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 171746.6 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 324.7 | |
| All* | Total formula weight | 172071.3 |
