6N84
 
 | | MBP-fusion protein of transducin-alpha residues 327-350 | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, SULFATE ION, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Srivastava, D, Gakhar, L, Artemyev, N.O. | | Deposit date: | 2018-11-28 | | Release date: | 2019-07-10 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
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6NU1
 | | Crystal Structure of Human PKM2 in Complex with L-cysteine | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, CYSTEINE, MAGNESIUM ION, ... | | Authors: | Srivastava, D, Nandi, S, Dey, M. | | Deposit date: | 2019-01-30 | | Release date: | 2019-08-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 58, 2019
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6NUB
 | | Pyruvate Kinase M2 Mutant - S437Y in Complex with L-serine | | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Srivastava, D, Nandi, S, Dey, M. | | Deposit date: | 2019-01-31 | | Release date: | 2019-08-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.7 Å) | | Cite: | Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 58, 2019
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6NU5
 | | Pyruvate Kinase M2 Mutant - S437Y in Complex with L-cysteine | | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CYSTEINE, ... | | Authors: | Srivastava, D, Nandi, S, Dey, M. | | Deposit date: | 2019-01-30 | | Release date: | 2019-08-21 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 58, 2019
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6N86
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1SR0
 | | Crystal structure of signalling protein from sheep(SPS-40) at 3.0A resolution using crystal grown in the presence of polysaccharides | | Descriptor: | beta-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, signal processing protein | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Singh, N, Kumar, J, Sharma, S, Singh, T.P. | | Deposit date: | 2004-03-22 | | Release date: | 2004-05-25 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.05 Å) | | Cite: | Crystal structure of signalling protein from sheep(SPS-40) at 3.0A resolution using crystal grown in the presence of polysaccharides
To be Published
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1XHG
 | | Crystal structure of a 40 kDa signalling protein from Porcine (SPP-40) at 2.89A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SPP-40 | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Singh, N, Kaur, P, Sharma, S, Singh, T.P. | | Deposit date: | 2004-09-19 | | Release date: | 2004-11-02 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Crystal structure of a 40 kDa signalling protein from Porcine (SPP-40) at 2.89A resolution.
To be Published
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1XRV
 | | Crystal Structure of the novel secretory signalling protein from Porcine (SPP-40) at 2.1A resolution. | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, signal processing protein | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Singh, N, Sharma, S, Singh, T.P. | | Deposit date: | 2004-10-16 | | Release date: | 2004-11-02 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Crystal Structure of the novel secretory signalling protein from Porcine (SPP-40) at 2.1A resolution.
TO BE PUBLISHED
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6N85
 | | Resistance to inhibitors of cholinesterase 8A (Ric8A) protein in complex with MBP-tagged transducin-alpha residues 327-350 | | Descriptor: | Maltose/maltodextrin-binding periplasmic protein,Guanine nucleotide-binding protein G(t) subunit alpha-2, Synembryn-A, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | | Authors: | Srivastava, D, Gakhar, L, Artemyev, N.O. | | Deposit date: | 2018-11-28 | | Release date: | 2019-07-10 | | Last modified: | 2021-11-24 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structural underpinnings of Ric8A function as a G-protein alpha-subunit chaperone and guanine-nucleotide exchange factor.
Nat Commun, 10, 2019
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4L5G
 | | Crystal structure of Thermus thermophilus CarD | | Descriptor: | CarD | | Authors: | Srivastava, D.B, Westblade, L.F, Campbell, E.A, Darst, S.A. | | Deposit date: | 2013-06-11 | | Release date: | 2013-07-31 | | Last modified: | 2013-08-21 | | Method: | X-RAY DIFFRACTION (2.3902 Å) | | Cite: | Structure and function of CarD, an essential mycobacterial transcription factor.
Proc.Natl.Acad.Sci.USA, 110, 2013
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2FDM
 | | Crystal structure of the ternary complex of signalling glycoprotein frm sheep (SPS-40)with hexasaccharide (NAG6) and peptide Trp-Pro-Trp at 3.0A resolution | | Descriptor: | 2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Chitinase-3-like protein 1, ... | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Somvanshi, R.K, Sharma, S, Singh, T.P. | | Deposit date: | 2005-12-14 | | Release date: | 2006-01-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Crystal structure of the ternary complex of signalling glycoprotein frm sheep (SPS-40)
with hexasaccharide (NAG6) and peptide Trp-Pro-Trp at 3.0A resolution
To be Published
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2G41
 | | Crystal structure of the complex of sheep signalling glycoprotein with chitin trimer at 3.0A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, SIGNAL PROCESSING PROTEIN, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Bhushan, A, Sharma, S, Singh, T.P. | | Deposit date: | 2006-02-21 | | Release date: | 2006-04-04 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides
J.Struct.Biol., 158, 2007
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2DSV
 | | Interactions of protective signalling factor with chitin-like polysaccharide: Crystal structure of the complex between signalling protein from sheep (SPS-40) and a hexasaccharide at 2.5A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Sharma, S, Bhushan, A, Srinivasan, A, Singh, T.P. | | Deposit date: | 2006-07-07 | | Release date: | 2006-08-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.54 Å) | | Cite: | Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides
J.Struct.Biol., 158, 2007
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2DSU
 | | Binding of chitin-like polysaccharide to protective signalling factor: Crystal structure of the complex formed between signalling protein from sheep (SPS-40) with a tetrasaccharide at 2.2 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, Chitinase-3-like protein 1, alpha-D-mannopyranose-(1-4)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Sharma, S, Kaur, P, Bhushan, A, Singh, T.P. | | Deposit date: | 2006-07-07 | | Release date: | 2006-07-25 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides
J.Struct.Biol., 158, 2007
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2DSW
 | | Binding of chitin-like polysaccharides to protective signalling factor: crystal structure of the complex of signalling protein from sheep (SPS-40) with a pentasaccharide at 2.8 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3-like protein 1, alpha-D-mannopyranose-(1-4)-alpha-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Sharma, S, Kaur, P, Bhushan, A, Singh, T.P. | | Deposit date: | 2006-07-07 | | Release date: | 2006-08-01 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Carbohydrate binding properties and carbohydrate induced conformational switch in sheep secretory glycoprotein (SPS-40): crystal structures of four complexes of SPS-40 with chitin-like oligosaccharides
J.Struct.Biol., 158, 2007
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2DPE
 | | Crystal structure of a secretory 40KDA glycoprotein from sheep at 2.0A resolution | | Descriptor: | Chitinase-3-like protein 1, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Sharma, S, Das, U, Srinivasan, A, Singh, T.P. | | Deposit date: | 2006-05-11 | | Release date: | 2006-05-30 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Crystal structure of a secretory signalling glycoprotein from sheep at 2.0A resolution
J.Struct.Biol., 156, 2006
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1ZB5
 | | Recognition of peptide ligands by signalling protein from porcine mammary gland (SPP-40): Crystal structure of the complex of SPP-40 with a peptide Trp-Pro-Trp at 2.45A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, PEPTIDE TRP-PRO-TRP, signal processing protein | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Somvanshi, R.K, Sharma, S, Dey, S, Kaur, P, Singh, T.P. | | Deposit date: | 2005-04-07 | | Release date: | 2005-05-10 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Recognition of peptide ligands by signalling protein from porcine mammary gland (SPP-40): Crystal structure of the complex of SPP-40 with a peptide Trp-Pro-Trp at 2.45A resolution
To be Published
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1ZBC
 | | Crystal Structure of the porcine signalling protein liganded with the peptide Trp-Pro-Trp (WPW) at 2.3 A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3 mer peptide, signal processing protein | | Authors: | Srivastava, D.B, Kaur, P, Kumar, J, Somvanshi, R.K, Sharma, S, Dey, S, Singh, T.P. | | Deposit date: | 2005-04-08 | | Release date: | 2005-04-19 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.29 Å) | | Cite: | Crystal Structure of the porcine signalling protein liganded with the peptide Trp-Pro-Trp (WPW) at 2.3 A resolution
To be Published
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8EOB
 | | Cryo-EM structure of human HSP90B in the closed state | | Descriptor: | Heat shock protein HSP 90-beta, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | | Authors: | Srivastava, D, Artemyev, N.O. | | Deposit date: | 2022-10-02 | | Release date: | 2023-01-25 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (3.1 Å) | | Cite: | Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
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8EOA
 | | Cryo-EM structure of human HSP90B-AIPL1 complex | | Descriptor: | Aryl-hydrocarbon-interacting protein-like 1, Heat shock protein HSP 90-beta, MAGNESIUM ION, ... | | Authors: | Srivastava, D, Artemyev, N.O. | | Deposit date: | 2022-10-02 | | Release date: | 2023-01-25 | | Last modified: | 2023-03-15 | | Method: | ELECTRON MICROSCOPY (3.9 Å) | | Cite: | Unique interface and dynamics of the complex of HSP90 with a specialized cochaperone AIPL1.
Structure, 31, 2023
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1ZBK
 | | Recognition of specific peptide sequences by signalling protein from sheep mammary gland (SPS-40): Crystal structure of the complex of SPS-40 with a peptide Trp-Pro-Trp at 2.9A resolution | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Chitinase-3 like protein 1, PEPTIDE TRP-PRO-TRP | | Authors: | Srivastava, D.B, Ethayathulla, A.S, Kumar, J, Singh, N, Somvanshi, R.K, Sharma, S, Dey, S, Singh, T.P. | | Deposit date: | 2005-04-08 | | Release date: | 2005-05-03 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Recognition of specific peptide sequences by signalling protein from sheep mammary gland (SPS-40): Crystal structure of the complex of SPS-40 with a peptide Trp-Pro-Trp at 2.9A resolution
To be Published
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7UMO
 | | Structure of Unc119-inhibitor complex. | | Descriptor: | (3s,5s,7s)-N-(4,5-dichloropyridin-2-yl)adamantane-1-carboxamide, GLYCEROL, Protein unc-119 homolog A | | Authors: | Srivastava, D, Sebag, J.A, Artemyev, N.O. | | Deposit date: | 2022-04-07 | | Release date: | 2023-07-26 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Insulin sensitization by small molecules enhancing GLUT4 translocation.
Cell Chem Biol, 30, 2023
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6A6Y
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6B6U
 | | Pyruvate Kinase M2 mutant - S437Y | | Descriptor: | 1,2-ETHANEDIOL, 2-[3-(2-HYDROXY-1,1-DIHYDROXYMETHYL-ETHYLAMINO)-PROPYLAMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, CHLORIDE ION, ... | | Authors: | Srivastava, D, Dey, M. | | Deposit date: | 2017-10-03 | | Release date: | 2017-12-20 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Structural Investigation of a Dimeric Variant of Pyruvate Kinase Muscle Isoform 2.
Biochemistry, 56, 2017
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8G0M
 | | Structure of complex between TV6.6 and CD98hc ECD | | Descriptor: | 1,2-ETHANEDIOL, 4F2 cell-surface antigen heavy chain, TETRAETHYLENE GLYCOL, ... | | Authors: | Kariolis, M.S, Lexa, K, Liau, N.P.D, Srivastava, D, Tran, H, Wells, R.C. | | Deposit date: | 2023-01-31 | | Release date: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | CD98hc is a target for brain delivery of biotherapeutics.
Nat Commun, 14, 2023
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