6NU1

Crystal Structure of Human PKM2 in Complex with L-cysteine

Summary for 6NU1

Entry DOI	10.2210/pdb6nu1/pdb
Descriptor	Pyruvate kinase PKM, CYSTEINE, 1,6-di-O-phosphono-beta-D-fructofuranose, ... (7 entities in total)
Functional Keywords	pyruvate kinase m2, cysteine, inhibition, glycolysis, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	4
Total formula weight	243125.59
Authors	Srivastava, D.,Nandi, S.,Dey, M. (deposition date: 2019-01-30, release date: 2019-08-21, Last modification date: 2023-10-11)
Primary citation	Srivastava, D.,Nandi, S.,Dey, M. Mechanistic and Structural Insights into Cysteine-Mediated Inhibition of Pyruvate Kinase Muscle Isoform 2. Biochemistry, 58:3669-3682, 2019 Cited by PubMed: 31386812 DOI: 10.1021/acs.biochem.9b00349 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.25 Å)

Structure validation