8G0M

Structure of complex between TV6.6 and CD98hc ECD

Summary for 8G0M

• Entry DOI: 10.2210/pdb8g0m/pdb
• Descriptor: 4F2 cell-surface antigen heavy chain, TV 6.6 Fc fragment, beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• Functional Keywords: transport vehicle, transport protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 74635.94

Authors

Kariolis, M.S.,Lexa, K.,Liau, N.P.D.,Srivastava, D.,Tran, H.,Wells, R.C. (deposition date: 2023-01-31, release date: 2023-10-18)

• Primary citation: Chew, K.S.,Wells, R.C.,Moshkforoush, A.,Chan, D.,Lechtenberg, K.J.,Tran, H.L.,Chow, J.,Kim, D.J.,Robles-Colmenares, Y.,Srivastava, D.B.,Tong, R.K.,Tong, M.,Xa, K.,Yang, A.,Zhou, Y.,Akkapeddi, P.,Annamalai, L.,Bajc, K.,Blanchette, M.,Cherf, G.M.,Earr, T.K.,Gill, A.,Huynh, D.,Joy, D.,Knight, K.N.,Lac, D.,Leung, A.W.,Lexa, K.W.,Liau, N.P.D.,Becerra, I.,Malfavon, M.,McInnes, J.,Nguyen, H.N.,Lozano, E.I.,Pizzo, M.E.,Roche, E.,Sacayon, P.,Calvert, M.E.K.,Daneman, R.,Dennis, M.S.,Duque, J.,Gadkar, K.,Lewcock, J.W.,Mahon, C.S.,Meisner, R.,Solanoy, H.,Thorne, R.G.,Watts, R.J.,Zuchero, Y.J.Y.,Kariolis, M.S.; CD98hc is a target for brain delivery of biotherapeutics.; Nat Commun, 14:5053-5053, 2023; PubMed: 37598178; DOI: 10.1038/s41467-023-40681-4

Experimental method

X-RAY DIFFRACTION (2.25 Å)