8G0M
Structure of complex between TV6.6 and CD98hc ECD
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | 4F2 cell-surface antigen heavy chain | polymer | 425 | 46951.7 | 1 | UniProt (P08195) Pfam (PF00128) | Homo sapiens (human) | CD98 heavy chain, CD98hc, 4F2hc,4F2 heavy chain antigen,Lymphocyte activation antigen 4F2 large subunit,Solute carrier family 3 member 2 |
| 2 | B (B) | TV 6.6 Fc fragment | polymer | 227 | 25757.3 | 1 | synthetic construct | ||
| 3 | C (C) | beta-D-galactopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-[alpha-D-mannopyranose-(1-3)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose | branched | 1422.3 | 1 | In PDB GlyTouCan (G61334IA) | |||
| 4 | D, F, G, H, I (A, B) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 5 | Chemie (EDO) | |||
| 5 | E (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 6 | J, K (A, B) | water | water | 18.0 | 157 | Chemie (HOH) |
Sequence modifications
A: 212 - 630 (UniProt: P08195)
| PDB | External Database | Details |
|---|---|---|
| Glu 631 | - | expression tag |
| Asn 632 | - | expression tag |
| Leu 633 | - | expression tag |
| Tyr 634 | - | expression tag |
| Phe 635 | - | expression tag |
| Gln 636 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 72709.1 | |
| Branched | Number of molecules | 1 |
| Total formula weight | 1422.3 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 504.6 | |
| All* | Total formula weight | 74635.9 |
