PDB: 1828 件ウェブページステータス検索Chemie searchBIRD

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3OLF	Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid 分子名称: 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-26 公開日 2011-01-19 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties Bioorg.Med.Chem.Lett., 21, 2011
3OLS	Crystal structure of estrogen receptor beta ligand binding domain 分子名称: ESTRADIOL, Estrogen receptor beta, Nuclear receptor coactivator 1 著者 Moecklinghoff, S, Rose, R, Carraz, M, Visser, A, Ottmann, C, Brunsveld, L. 登録日 2010-08-26 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Synthesis and crystal structure of a phosphorylated estrogen receptor ligand binding domain. Chembiochem, 11, 2010
3OKI	Crystal structure of human FXR in complex with (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide 分子名称: (2S)-2-[2-(4-chlorophenyl)-1H-benzimidazol-1-yl]-N,2-dicyclohexylethanamide, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-25 公開日 2010-12-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes Bioorg.Med.Chem.Lett., 21, 2010
3OKH	Crystal structure of human FXR in complex with 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid 分子名称: 2-(4-chlorophenyl)-1-[(1S)-1-cyclohexyl-2-(cyclohexylamino)-2-oxoethyl]-1H-benzimidazole-6-carboxylic acid, Bile acid receptor, peptide of Nuclear receptor coactivator 1 著者 Rudolph, M.G. 登録日 2010-08-25 公開日 2010-12-29 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Discovery of novel and orally active FXR agonists for the potential treatment of dyslipidemia & diabetes Bioorg.Med.Chem.Lett., 21, 2010
3OGT	Design, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3. 分子名称: (1S,3R,5Z,7E,14beta,17alpha,20S)-20-[5-(1-hydroxy-1-methylethyl)furan-2-yl]-9,10-secopregna-5,7,10-triene-1,3-diol, SULFATE ION, Vitamin D3 receptor 著者 Huet, T, Fraga, R, Mourino, A, Moras, D, Rochel, N. 登録日 2010-08-17 公開日 2011-08-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Design, Chemical synthesis, Functional characterization and Crystal structure of the sidechain analogue of 1,25-dihydroxyvitamin D3. To be Published
3OAP	Crystal structure of human Retinoid X Receptor alpha-ligand binding domain complex with 9-cis retinoic acid and the coactivator peptide GRIP-1 分子名称: (9cis)-retinoic acid, Nuclear receptor coactivator 2, Retinoic acid receptor RXR-alpha 著者 Xia, G, Smith, C.D, Muccio, D.D. 登録日 2010-08-05 公開日 2010-11-17 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Structure, Energetics and Dynamics of Binding Coactivator Peptide to Human Retinoid X Receptor Alpha Ligand Binding Domain Complex with 9-cis-Retinoic Acid. Biochemistry, 50, 2011
3O1D	Structure-function study of Gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097. 分子名称: (1R,3R,7E,17beta)-17-[(1S)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,10-secoestra-5,7-diene-1,3-diol, Nuclear receptor coactivator 2, Vitamin D3 receptor A 著者 Huet, T, Moras, D, Rochel, N. 登録日 2010-07-21 公開日 2011-07-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.4007 Å) 主引用文献 Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097. Medchemcomm, 2, 2011
3O1E	Structure-function of Gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097. 分子名称: (1R,3R,7E,17beta)-17-[(1R)-6,6,6-trifluoro-5-hydroxy-1-(4-hydroxy-4-methylpentyl)-5-(trifluoromethyl)hex-3-yn-1-yl]-9,1 0-secoestra-5,7-diene-1,3-diol, Nuclear receptor coactivator 2, Vitamin D3 receptor A 著者 Huet, T, Moras, D, Rochel, N. 登録日 2010-07-21 公開日 2011-07-06 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.5001 Å) 主引用文献 Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097. Medchemcomm, 2, 2011
2XKW	LIGAND BINDING DOMAIN OF HUMAN PPAR-GAMMA IN COMPLEX WITH THE AGONIST PIOGLITAZONE 分子名称: (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, 2-{2-[2-(2-{2-[2-(2-ETHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... 著者 Mueller, J.J, Schupp, M, Unger, T, Kintscher, U, Heinemann, U. 登録日 2010-07-14 公開日 2011-08-10 最終更新日 2023-12-20 実験手法 X-RAY DIFFRACTION (2.02 Å) 主引用文献 Binding Diversity of Pioglitazone by Peroxisome Proliferator-Activated Receptor-Gamma To be Published
3NSP	Crystal structure of tetrameric RXRalpha-LBD 分子名称: Retinoid X receptor, alpha 著者 Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X. 登録日 2010-07-02 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J.Biol.Chem., 286, 2011
3NSQ	Crystal structure of tetrameric RXRalpha-LBD complexed with antagonist danthron 分子名称: 1,8-dihydroxyanthracene-9,10-dione, Retinoid X receptor, alpha 著者 Zhang, H, Hu, T, Li, L, Zhou, R, Chen, L, Hu, L, Jiang, H, Shen, X. 登録日 2010-07-02 公開日 2010-11-17 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor. J.Biol.Chem., 286, 2011
3NOA	Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist 分子名称: (5-{3-[4-(biphenyl-4-ylcarbonyl)-2-propylphenoxy]propoxy}-1H-indol-1-yl)acetic acid, Peroxisome proliferator-activated receptor gamma 著者 Peng, Y.H, Wu, J.S, Wu, S.Y. 登録日 2010-06-25 公開日 2011-06-29 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 Crystal structure of human PPAR-gamma ligand binding domain complex with a potency improved agonist To be published
2XHS	Crystal structure of the ligand binding domain of Fushi tarazu factor 1 of Drosophila melanogaster. 分子名称: NUCLEAR HORMONE RECEPTOR FTZ-F1, SEGMENTATION PROTEIN FUSHI TARAZU 著者 Yoo, J.H, Cho, H.S. 登録日 2010-06-21 公開日 2011-07-20 最終更新日 2018-06-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal Structure of Fushi Tarazu Factor 1 Ligand Binding Domain/Fushi Tarazu Peptide Complex Identifies New Class of Nuclear Receptors. J.Biol.Chem., 286, 2011
3N00	Crystal Structure of a deletion mutant of human Reverba ligand binding domain bound with an NCoR ID1 peptide determined to 2.60A 分子名称: Nuclear receptor corepressor 1, Rev-erbA-alpha 著者 Gampe, R, Nolte, R. 登録日 2010-05-13 公開日 2010-06-30 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structure of Rev-erbalpha bound to N-CoR reveals a unique mechanism of nuclear receptor-co-repressor interaction. Nat.Struct.Mol.Biol., 17, 2010
3MNO	Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, F608S) mutations at 1.55A 分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... 著者 Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. 登録日 2010-04-22 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
3MNP	Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by (A611V, V708A, E711G) mutations at 1.50A 分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... 著者 Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. 登録日 2010-04-22 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
3MNE	Crystal structure of the agonist form of mouse glucocorticoid receptor stabilized by F608S mutation at 1.96A 分子名称: DEXAMETHASONE, GLYCEROL, Glucocorticoid receptor, ... 著者 Schoch, G.A, Seitz, T, Benz, J, Banner, D, Stihle, M, D'Arcy, B, Thoma, R, Sterner, R, Hennig, M, Ruf, A. 登録日 2010-04-21 公開日 2010-09-15 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (1.96 Å) 主引用文献 Enhancing the stability and solubility of the glucocorticoid receptor ligand-binding domain by high-throughput library screening. J.Mol.Biol., 403, 2010
3M7R	Crystal structure of VDR H305Q mutant 分子名称: 5-{2-[1-(5-HYDROXY-1,5-DIMETHYL-HEXYL)-7A-METHYL-OCTAHYDRO-INDEN-4-YLIDENE]-ETHYLIDENE}-4-METHYLENE-CYCLOHEXANE-1,3-DIOL, Vitamin D3 receptor 著者 Rochel, N, Hourai, S, Moras, D, Structural Proteomics in Europe (SPINE) 登録日 2010-03-17 公開日 2010-05-05 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand J.Steroid Biochem.Mol.Biol., 121, 2010
3AFR	Crystal Structure of VDR-LBD/22S-Butyl-1a,24R-dihydroxyvitamin D3 complex 分子名称: (1R,3S,5Z)-5-[(2E)-2-{(1R,3aS,7aR)-1-[(1R,2S,4R)-2-butyl-4-hydroxy-1,5-dimethylhexyl]-7a-methyloctahydro-4H-inden-4-yli dene}ethylidene]-4-methylidenecyclohexane-1,3-diol, 13-meric peptide from Mediator of RNA polymerase II transcription subunit 1, Vitamin D3 receptor 著者 Inaba, Y, Nakabayashi, M, Itoh, T, Ikura, T, Ito, N, Yamamoto, K. 登録日 2010-03-10 公開日 2010-03-31 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 22S-Butyl-1alpha,24R-dihydroxyvitamin D(3): Recovery of vitamin D receptor agonistic activity J.Steroid Biochem.Mol.Biol., 121, 2010
3LMP	Crystal structure of the PPARgamma-LBD complexed with a cercosporamide derivative modulator 分子名称: (9aS)-8-acetyl-1,7-dihydroxy-3-methoxy-9a-methyl-N-(1-naphthylmethyl)-9-oxo-9,9a-dihydrodibenzo[b,d]furan-4-carboxamide, Peptide of Nuclear receptor coactivator 1, Peroxisome proliferator-activated receptor gamma 著者 Matsui, Y, Hanzawa, H. 登録日 2010-01-31 公開日 2010-04-14 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of a novel selective PPARgamma modulator from (-)-Cercosporamide derivatives Bioorg.Med.Chem.Lett., 20, 2010
3ADS	Human PPARgamma ligand-binding domain in complex with indomethacin 分子名称: INDOMETHACIN, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010
3ADW	Human PPARgamma ligand-binding domain in complex with 5-methoxy-indole acetate and 15-oxo-eicosatetraenoic acid 分子名称: (5-methoxy-1H-indol-3-yl)acetic acid, (5E,8E,11Z,13E)-15-oxoicosa-5,8,11,13-tetraenoic acid, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.07 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010
3ADX	Human PPARgamma ligand-binding domain in complex with indomethacin and nitro-233 分子名称: 3-[5-(2-nitropent-1-en-1-yl)furan-2-yl]benzoic acid, INDOMETHACIN, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010
3ADT	Human PPARgamma ligand-binding domain in complex with 5-hydroxy-indole acetate 分子名称: (5-hydroxy-1H-indol-3-yl)acetic acid, Peroxisome proliferator-activated receptor gamma 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010
3ADV	Human PPARgamma ligand-binding domain in complex with serotonin 分子名称: Peroxisome proliferator-activated receptor gamma, SEROTONIN 著者 Waku, T, Shiraki, T, Oyama, T, Morikawa, K. 登録日 2010-01-29 公開日 2010-12-22 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 The nuclear receptor PPARgamma individually responds to serotonin- and fatty acid-metabolites Embo J., 29, 2010

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