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3OLF

Crystal structure of human FXR in complex with 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid

Summary for 3OLF
Entry DOI10.2210/pdb3olf/pdb
Related3OKH 3OKI 3OMK 3OMM 3OOF 3OOK
DescriptorBile acid receptor, peptide of Nuclear receptor coactivator 1, 4-({(2S)-2-[2-(4-chlorophenyl)-5,6-difluoro-1H-benzimidazol-1-yl]-2-cyclohexylacetyl}amino)-3-methylbenzoic acid, ... (4 entities in total)
Functional Keywordsnuclear receptor, cholesterol, bile acid, dna-binding, nucleus, receptor, transcription, ligand binding domain transcription regulation, coactivator, fxr alternative splicing, hormone receptor
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus (Probable): Q96RI1
Nucleus (By similarity): Q15788
Total number of polymer chains4
Total formula weight58856.40
Authors
Rudolph, M.G. (deposition date: 2010-08-26, release date: 2011-01-19, Last modification date: 2024-03-20)
Primary citationRichter, H.G.F.,Benson, G.M.,Bleicher, K.H.,Blum, D.,Chaput, E.,Clemann, N.,Feng, S.,Gardes, C.,Grether, U.,Hartman, P.,Kuhn, B.,Martin, R.E.,Plancher, J.M.,Rudolph, M.G.,Schuler, F.,Taylor, S.
Optimization of a novel class of benzimidazole-based farnesoid X receptor (FXR) agonists to improve physicochemical and ADME properties
Bioorg.Med.Chem.Lett., 21:1134-1140, 2011
Cited by
PubMed: 21269824
DOI: 10.1016/j.bmcl.2010.12.123
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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